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Research Focus
My research interests are in translational approaches to biomedical research.
What this really means is we are translating research discoveries into
commercial products. These products can be, for example, technologies
that will facilitate biomedical research such as new tools or novel genes
that could be targeted for discovering new drugs to treat disease. My
background in the biotechnology industry helped form this interest of
course and also provides a broad experience base for this work. In our
current research we create and utilize DNA microarrays (the image you
see on this page) for gene discovery and validation for potential therapeutic
drug discovery targets. This is a long term goal, particularly for multigenic
disease. The specific disease areas of interest are osteoporosis, bone
fracture healing and atrial fibrillation. In our ABL (Applied Bioscience
Laboratory) we use molecular and cell biology tools for the same goal.
We collaborate with academic and industry scientists on projects to facilitate
translational of research.
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Education
- Ph.D.- Molecular Biology, Stony Brook University, 1987
- M.S.- Clinical Chemistry, C.W. Post of Long Island University, 1976
- B.S.- Chemistry, Queens College of City University of New York, 1970
Academic Appointments
- 2000-present, Assistant Professor, Department of Biomedical Engineering
- 1998-present, Director for Scientific Affairs, The Center for Biotechnology
- 1999-2001, Director, University DNA Microarray Facility
- 1980-1982, Clinical Faculty, C.W. Post Medical Technology Graduate
Program
Professional Experience
- 2002, 2003, SBIR/STTR Reviewer, NSF Biotechnology
- 1987-1998, OSI Pharmaceuticals, Inc., Farmingdale, NY 11735
Senior Research Investigator, Technology Development Group
Manager of Core Screening and Compound Handling Group
Program Manager, Assay Development Group
Manager, Molecular Biology Research and Diagnostic Products
- 1970-1982, North Shore University Hospital, Manhasset, NY
Medical Technologist
Senior Medical Technologist
Supervisor of Automated Clinical Chemistry
Publications
Click
here to search Anil Dhundale's PubMed listings
- Dhundale, A., Furuichi, T., Inouye, M., Inouye, S., Distribution of
multicopy single-stranded DNA among myxobacteria and related species.
J. Bacteriology, 164, 914-917 (1985).
- Furuichi, T., Dhundale, A., Inouye, M., Inouye, S., Branched RNA covalently
linked to the 5' end of a single-stranded RNA in S. aurantiaca: Structure
of msDNA. Cell, 48, 47-53 (1987, featured on the cover of Cell).
- Inouye, M. and Dhundale, A., Stable branched RNA covalently linked
to the 5' end of a single-stranded DNA in myxobacteria. In "New
Perspectives of Molecular Biology of RNA. (eds.: M. Inouye and B. Dudock)
Academic Press, NY.
- Dhundale, A., Lampson, B., Furuichi, T., Inouye, M. and Inouye, S.,
Structure of msDNA from Myxococcus xanthus: Evidence for a long, self-annealing
RNA precursor for the covalently linked branched RNA. Cell, 51, 1105-1112
(1987).
- Dhundale, A., Inouye, M. and Inouye, S., A new species of multicopy
single-stranded DNA from Myxococcus xanthus with conserved structural
features. J. of Biol. Chem. 263, 18, 9055-9058 (1988).
- Dhundale, A., Furuichi, T., Inouye, M., and Inouye, S., Mutations
that affect production of branched RNA-linked msDNA in Myxococcus xanthus.
J. of Bacteriology 170, 12, 5620-5624 (1988).
- Case, C. and Dhundale, A., Gene regulation by antisense RNA and DNA
- a meeting review. Antisense Research and Development 1, 207-217, (1991).
- Dhundale, A. and Goddard, C., Reporter assays in the high throughput
screening laboratory: A rapid and robust first look? Journal of Biomolecular
Screening 1, 3, 115-118 (1996).
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