Clinton T. Rubin 

Distinguished Professor & Chair, Department of Biomedical Engineering
 

 
Research Focus

The major research focus of my work is targeted towards understanding the cellular mechanisms responsible for the growth, healing, and homeostasis of bone. More specifically, I am interested in how biophysical stimuli (i.e., mechanical, electrical, temperature, magnetic, pressure) mediate these responses. The clinical significance of this work is applicable to the inhibition of osteopenia, the promotion of bony ingrowth into prostheses or skeletal defects, and the acceleration of fracture healing. These goals are approached via interdisciplinary studies at the biochemical, molecular, cellular, tissue, organ, computational (e.g., FEM) and clinical levels.

 
Education

• Res. Fellow - Biomechanics, Brigham & Women's Hosp. Boston, MA, 1984-5
• Res. Assoc. - Cell Biology, Tufts Univ., Boston, MA, 1983-4
• Ph.D. - Anatomy, Univ. of Bristol, Bristol, U.K., 1983
• B.A. - Physiology, Harvard Univ., Cambridge, MA, 1977

 
Academic Appointments

• 2000- Chair, Department of Biomedical Engineering
• 1997- Visiting Scientist, Brookhaven National Laboratory, Upton, NY
• 1997- Director, Center for Advanced Technology in Medical Biotechnology, New York State office of Science, Technology and Academic Research
• 1995- Director, Program in Biomedical Engineering, S.U.N.Y., Stony Brook.
• 1992- Professor of Orthopaedics, Anatomy, Molecular Biophysics & Mechanical Eng. S.U.N.Y., Stony Brook.
• 1987- Director, Musculo-Skeletal Research Laboratory, S.U.N.Y., Stony Brook.
• 1987-92 Associate Professor of Orthopaedics, Anatomy, & Mechanical Engineering, S.U.N.Y., Stony Brook.
• 1984-87 Assistant Professor of Anatomy & Cell Biol., Tufts Univ. School Med., Boston, Mass.

 
Honors

• 2005 Distinguished Professor; highest academic rank in SUNY system, as conferred by SUNY Trustees
• 2003 Elizabeth Winston Lanier Kappa Delta Award for Outstanding Research, Amer.
  Academy of Orthopaedic Surgeons
• 2002 Fellow, American Institute of Medical and Biological Engineers
• 2002 Calgary Award in Orthopaedic Biomechanics, IV World Cong. Biomechanics
• 2001 NYSTAR Distinguished Professor, New York State Office of Technology and Academic Research
• 2000 Giovanni Borelli Award, American Society of Biomechanics
• 1998- Board of Directors, New York Biotechnology Association
• 1997- The Whitaker Foundation, Fellowship Advisory Committee
• 1996 Fuller Albright Award, American Society of Bone and Mineral Research
• 1994 Founder, Exogen, Inc.
• 1993 John Charnley Award, The Hip Society, Amer. Acad. Orthop. Surgeons
• 1990 Kappa Delta Award for Outstanding Research, Bioelectric Repair and Growth Society.
• 1989-1994 Committee on Space Biology & Medicine, Space Studies Board, National Research Council
• 1987-1992 Presidential Young Investigator Award, National Science Foundation.
• 1986 European Society of Biomechanics Award for Excellence in Research.
• 1985 Kappa Delta Society Young Investigator Award, Amer. Acad. Orthop. Surgeons.

 
Publications

Click here to search Clinton Rubin's PubMed listings

• Rubin, C., Capilla, E., Luu, Y-K, Busa, B., Rosen, C., Pessin, J. & Judex, S. (2007).  Adipogenesis is Suppressed by Brief, Daily Exposure to High Frequency, Extremely Low Magnitude Mechanical Signals.  Proc. Nat. Acad. Sci. 104:17879-17884

• Judex, S, Lei, X, Han, D. & Rubin, C. (2007) Low-Magnitude Mechanical Signals that Stimulate Bone Formation in the Ovariectomized Rat are Dependent on the Applied Frequency but not on the Strain Magnitude. J. Biomechanics. 40:1333-1339

• Garman, R.A., Gaudette, G., Donahue, L.R, Rubin, C.T., Judex, S. (2007) Acceleratory motions, applied in the absence of weightbearing, can be anabolic to bone. J. Orth. Research . J. Orthopaedic Research. 25:732-740

• Garman R, Rubin C & Judex S (2007) Small Oscillatory Accelerations, Independent of Matrix Deformations, Increase Osteoblast Activity and Enhance Bone Morphology. PLoS ONE 2(7): e653. doi:10.1371/journal.pone.0000653

• Mittra, E., Rubin, C., Gruber, B. & Qin, Y-X. (2007) Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, micro-CT, and DXA.  J. Biomech. Epub ahead of print

• Gilsanz, V., Wren, T., Sanchez, M., Dorey, F., Judex, S. & Rubin, C.  (2006)  Low Level, High Frequency Mechanical Signals Enhance Musculoskeletal Development of Young Women with Low Bone Density. J. Bone & Mineral Research 21:1464-1474/

• Rubin, C., Judex, S. & Qin, Y-X. (2006)  Low-level mechanical signals and their potential as a non-pharmacologic intervention for osteoporosis.  /Age and Ageing / 35:32-36

• Judex, S, Lei, X, Han, D. & Rubin, C. (2006) Low-Magnitude Mechanical Signals that Stimulate Bone Formation in the Ovariectomized Rat are Dependent on the Applied Frequency but not on the Strain Magnitude. J. Biomechanics. /(in press).

• Rubin, J., Rubin, C. & Jacobs, C. (2006). Molecular Pathways Mediating Mechanical Signaling in Bone. Gene. (in press, available on line).
   
• Mittra, E., Rubin, C. & Qin, Y-X. (2005) Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J. Biomech. 38:1229-1237
   
• Busa B, Miller LM, Rubin CT, Qin YX, & Judex S. (2005) Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tissue Int. 77:386-94.
   
• Murfee, W., Hammett, L., Evans, C., Xie, L., Squire, M., Rubin, C., Judex, S. & Skalak, T. (2005). High-frequency low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle. J. App. Physiol. 98:2376-2380
   
• Judex S, Zhong N, Squire ME, Ye K, Donahue LR, & Rubin, C. (2005) Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue. J Cell Biochem. 94:982-994.
   
• Zhong N, Garman RA, Squire ME, Donahue LR, Rubin C & Judex, S. (2005) Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of mice. Aviat Space Environ Med; 76:530-535.
   
• Hannan, M., Cheng, D., Greeen, E., Swift, C., Rubin, C. & Kiel, D. (2004) Establishing the compliance in elderly women for use of a low level mechanical stress device in a clinical osteoporosis study. Osteoporosis International 15:918-926
   
• Judex, S., Garman, S., Squire, M., Bhusa, B., Donahue, L.R. & Rubin, C.T. (2004) Genetically linked site-specificity of disuse osteoporosis. J.Bone and Mineral Research. 19:607-614
   
• Squire, M., Donahue, L.R., Rubin, C.T., Judex, S. (2004) Genetic variations that regulate bone morphology in the male skeleton do not influence its susceptibility to mechanical unloading. Bone 35(6), 1353-1360.
   
• Judex, S., Garman, S., Squire, M., Donahue, L.R. & Rubin, C.T. (2004) Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology. Journal of Bone and Mineral Research. 19:600-607
   
• Rubin, C.T., Recker, R., Raab, D., Ryaby, J., McCabe, J. & McLeod, K.J. (2004) Prevention of Post-Menopausal Bone Loss by a Low Magnitude, High Frequency Mechanical Stimuli; A Clinical Trial Assessing Compliance, Efficacy And Safety. J. Bone & Mineral Research. 19:343-351
   
• Ward, K., Alsop, C., Brown, S., Caulton, J., Rubin, C., Adams, J. & Mughal, M. (2004) Low magnitude, high frequency loading therapy increases volumetric tibial bone mineral density in children with disabling conditions. J. Bone & Mineral Research: 19:360-369
    
• Rubin, C., Pope, M, Fritton, C., Magnusson, M., Hansson, T. & McLeod, K. (2003). Transmissibility of 15-35 Hz vibrations to the human hip and lumbar spine: Determining the physiologic feasibility of delivering low-level, anabolic mechanical stimuli to skeletal regions at greatest risk of fracture due to osteoporosis. Spine; 28:2621-2627
   
• Qin, Y-X., Kaplan, T., Saldana, A. and Rubin, C.T. (2003): Fluid Pressure Gradients, Arising from Oscillations in Intramedullary Pressure, is Correlated with the Formation of Bone and Inhibition of Intracortical Porosity. J Biomech, 36:1427-1437.
   
• Judex S, Boyd SK, Qin YX, Turner S, Ye K, Mueller R, Rubin C (2003) Adaptations of Trabecular Bone to Low Magnitude Vibrations Result in More Uniform Stress and Strain Under Load. Ann Biomed Eng. 31:12-20.
   
• Judex, S., Boyd, S., Qin, Y-X, Miller, L., Müller, R., Rubin, C. (2003) Combining High-Resolution MicroCT with Material Composition to Define the Quality of Bone Tissue. Current Osteoporosis Reports. 1:11-19
   
• Judex, S., Donahue, L.R., Rubin, C.T. (2002) Genotypic predisposition to osteoporosis is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. The FASEB Journa Express Article. 10.1096/fj.01-0913fje
   
• Hadjiargyrou M, Lombardo F, Zhao S, Ahrens W, Joo J, Ahn H, White DW, Rubin CT. Transciptional profiling of bone regeneration: Insight into the molecular complexity of wound repair. J Biol Chem 2002.
   
• Rubin C, Turner AS, Mallinckrodt C, Jerome C, McLeod K, Bain S. Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Bone 2002 Mar; 30(3):445-52.
   
• Rubin C, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 2002 Feb; 17(2):349-57.
   
• Rubin, C., Turner, S. Bain, S., Mallinckrodt, C. & McLeod, K. (2001) Extremely Low Level Mechanical Signals are Anabolic to Trabecular Bone. Nature 412:603-604.
   
• Rubin C, Xu G, Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J. 2001; 15(12):2225-9.
   
• D. W. Sommerfeldt, C. T. Rubin. (2001) Biology of bone and how it orchestrates the form and function of the skeleton. Eur Spine J, DOI 10.1007/s005860100283
   
•  Rubin, C, Sommerfeldt, D, Judex, S & Qin, Y-X. (2001) Inhibition of Osteopenia by Low Magnitude, High Frequency Mechanical Stimuli. Drug Discovery Today 6:848-858.
   
• Rubin, C., Bolander, M., Ryaby, J. & Hadjiargyrou, M. (2001) The use of low intensity ultrasound to accelerate the healing of fractures. J. Bone & Jt. Surg. 83:259-70.
   
• Lin, W., Qin, Y.-X. & Rubin, C.T. (2001) Ultrasonic wave propagation in trabecular bone predicted by the stratified model. Annals of Biomed. Eng. 29(9):1-10.
   
• Rubin, C., Alikhani, M. and Rubin, J. (2001) Comparative Skeletal Structure. In: Encyclopedia Life Sciences; Nature Press (in press).
   
• Sommerfeldt DW, McLeod KJ, Rubin CT, Hadjiargyrou M. Differential phosphorylation of paxillin in response to surface-bound serum proteins during early osteoblast adhesion. Biochem Biophys Res Commun. 2001 Jul 13; 285(2):355-63.
   
• Fritton, S.P., McLeod, K.J., Rubin, C.T. (2000) Quantifying the strain history of bone: spatial uniformity and self-similarity of low magnitude strains. J. Biomech. 33:317-326.
   
• Hadjiargyrou, M., Ahrens, W. & Rubin, C. (2000) Expression and function of CYR-61 in the healing fracture. J. Bone & Min. Res 15:1014-1023
   
• Rubin, C. and Rubin, J. (2000) Biomechanics of Bone. Primer for Metabolic Bone Diseases and Disorders of Mineral Metabolism. ed: M. Fauvus. Lippincott-Raven ch 5: p 39-42
   
• Vander Molen, M.A., Donahue. H.J., Rubin, C.T. & McLeod, K.J. (2000) Gap junctions alter the kinetics of electric field induced differentiation in osteoblastic cells. Bone . 27(2):227-31
   
• Rubin, J., Rubin, H., & Rubin, C. (1999) Constraints of experimental paradigms used to model the aging skeleton. The Aging Skeleton, eds: C.Rosen, J.Glowacki & J.Bilizekian. Acad. Press Ch.4; p27-36.
   
• Rubin, C., Zhi, J., Xu, G., Cute, M., McLeod, K. and Hadjiargyrou, M. (1999) Expression of novel gene products upregulated by disuse is normalized by an osteogenic mechanical stimulus: NASA Space Biology Program; Biomedical Investigators' Workshop, Jan. 11-13, League City, Texas.
   
• McLeod, K.J., Turner, A.S., Mallinckrodt, C.H. & Rubin, C.T. (1999) Frequency and duration optimization of dynamic loading protocols for the reversal of osteopenia. 45th Ann. Mtg. Orthop. Res. Soc.:24:571
   
• Qin, Y.X., McLeod, K.J., Lin, W., Gray, J., Turner, A.S. & Rubin, C.T. (1999) Trabecular strength is enhanced by low magnitude and high frequency mechanical stimuli as determined by CT number, ultrasonic velocity and force-displacement measurements. 45th Ann. Mtg. Orthop. Res. Soc. 24:568.
   
• Rubin, J. & Rubin, C. (1999) Genetic and Epigenetic Influences on Bone Strength. In: Osteoporosis: Genetics, Prevention and Treatment, eds: J. Adams & B. Lukert, Kluwer Publ., Newt., MA p.57-72 .
   
• Rubin, J., Fan, X., Biskobing, D., Taylor, W. & Rubin, C. (1999) Osteoclast formation is attenuated in a dose-dependent and site-specific manner by physiologic levels of strain. J. Orth. Res, 17:639-645.
   
• Huang, R., McLeod, K. & Rubin, C. (1999) Changes in the dynamics of muscle contraction as a function of age; A contributing factor to the etiology of osteoporosis? J. Gerontology 54:352-357.
   
• Rubin, C., Recker, R., Cullen, D., Ryaby, J. & McLeod, K. (1998) Prevention of bone loss in a post-menopausal population by low-level biomechanical intervention. Amer. Sc. Bone Min Res: 23:1106
   
• Rubin, C. Turner, S., Jerome, C. Strachan, M., Bain, S., & McLeod, K. (1998). Low magnitude, high frequency mechanical stimulation increases trabecular density of the proximal femur. Amer Soc.Bone Min Res: 23:1126
   
• Qin, Y-X., Rubin, C. & McLeod, K. (1998) Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology. J. Orth. Res. 16:482-489.
   
• Hadjiargyrou, M., Halsey, M., Ahrens, W., Rightmire, E., McLeod, K & Rubin, C. (1998) Cloning of a novel cDNA expressed during the early stages of fracture healing. Biochm & Biophys. Res. Com 249:879-884
   
• Otter, M., Rubin, C., and McLeod, K. (1998) Stochastic modulation of cell shape by low-level mechanical loading. The Amer. J. Med. Sciences 316(3):176-183.
   
• Demes, B., Stern, J., Larson, S. & Hausman, M, Rubin, C., (1998) Bone strain in the macaque ulna during locomotion. J. Phys. Anthrop 106:87-100
   
• Hadjiargyrou, M., McLeod, K., Ryaby, J. & Rubin, C.(1998) Augmentation of Fracture Healing by Low Intensity Ultrasound.. Clin. Orth. Rel. Res. 355:216-229
   
• Adams, D., Spirt, A., Brown, T., Fritton, S., Rubin, C. & Brand, R. (1997) Testing the "daily stress stimulus" hypothesis of bone remodeling. J. Biomech30:671-678.
   
• Fritton, J., Rubin, C., Qin, Y.-X. & McLeod, K. (1997) Vibration in the skeleton. Part I: Development of a resonance-based whole body vibration device. J. Biomed Eng. 25:831-839.
   
• Gross, T.S., Edwards, J.L., McLeod, K.J. & Rubin, C.T. (1997) Strain gradients correlate with sites of periosteal bone formation. J. Bone Min. Res. 12(6):982-988.
   
• Rubin, C. T. & McLeod, K. (1996) Inhibition of osteopenia by biophysical intervention. In: Osteoporosis, Eds: R. Marcus, J. Kelsey & D. Feldman. Academic Press Ch. ch. 5, pp351-371.
   
• Rubin, C., Sun, Y-Q, Hadjiargyrou, M. & McLeod, K. (1999) Increased expression of MMP-1 mRNA in osteocytes precedes bone resorption as stimulated by disuse: Evidence for the autoregulation of the bone's mechanical environment? J. Orth. Res.; 17: 354-361.
   
• Rubin, C., Gross, T., Qin, Y., Fritton, S., Guilak, F. & McLeod, K.J. (1996) Differentiation of bone-tissue remodeling response to axial and torsional loading. J. Bone Jt. Surg. 78(10):1523-1533.
   
• Qin, Y., McLeod, K., Guilak, F. and Rubin, C. (1996) Correlation of bony ingrowth with the distribution of stress and strain parameters surrounding a porous-coated implant. J. Orth. Res. 14:862-870.
   
• Rubin, J., McLeod, K., Titus, L., Nanes, M., Catherwood, B. and Rubin, C. (1996) Formation of osteoclast-like cells is suppressed by low frequency, low intensity electric fields. J. Orth. Res. 14:7-15.
   
• Ricos, V., Pedersen, D., Brown, T, Rubin, C., & Brand, R. (1996) Effects of anisotropy and material axis registration on computed stress and strain distributions in the turkey ulna. J. Biomec. 29:261-267.
   
• Sun, Y-Q., McLeod, K. & Rubin, C. (1995) Mechanically induced periosteal bone formation is paralleled by the upregulation of collagen type one mRNA in osteocytes as measured by IS-RT-PCR. Calc. Tiss. Intl. 57:456-462.
   
• Gross, T. and Rubin, C. (1995) Uniformity of resorptive bone loss induced by disuse. J. Orth. Res. 13(5):708-714.
   
• Rubin, C.T., Gross, T.S., McLeod, K.J. & Bain, S.D. (1995) Morphologic stages in lamellar bone formation stimulated by a potent mechanical stimulus. J. Bone Min. Res. 10(3):488-495.
   
• Rubin, C. & McLeod (1994) Promotion of bony ingrowth by frequency specific, low amplitude mechanical strains. John Charnley Award of The Hip Society. Clin. Orth. Rel. Res. 298:165-174
   

 
Patents

• Method for inducing a current and voltage in living tissue for the prevention of bone loss. Patent #4,993,413
   
• Mechanical loading protocol for the prevention of osteoporosis, acceleration of fracture healing, and the promotion of bony ingrowth. #5,103,808
   
• Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue. #5,191,880
   
• Apparatus for the induction of high frequency strains into the axial skeleton to promote growth and repair. #5,273,028
   
• Non-Invasive method and means for in-vivo bone-growth stimulation. #5,376,065
   
• Method and system for therapeutically treating bone fractures and osteoporosis. #5,997,490
   
• Method and system for therapeutically treating bone fractures and osteoporosis. #6,022,349
   
• Chondrogenic and osteogenic genes to be used in the treatment of metabolic bone disease. Pending
   
• Frequency scanning ultrasound as a non-invasive means to determine the physical properties of bone. Pending
   
• Improvement of postural stability using low level, high frequency mechanical oscillations. Pending