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Ki H. Chon 

Professor
 

On This Page :
  Research Focus
  Education
  Professional Experience
  Grants
  Publications
  •PubMed listings
   
   
  Related Labs + Depts
  Physiology
  Biophysics
    

 
  Contact Info
 


Ki H. Chon

T: 631.444.7286
F: 631.444.3432
E: ki.chon@sunysb.edu
 
Office:
HSC T18 Room 030
Stony Brook, NY
11794-8181
   

 

 

 

  

Research Focus

The cardiac autonomic nervous system is responsible for maintaining proper homeostasis, or balance, of the cardiovascular system. One of our major areas of research is to detect, quantify, and interpret differences in dynamic characteristics of the cardiac autonomic nervous system between normal and diseased subjects, in an attempt to find a marker for increased risk of sudden cardiac death. Identifying and quantifying differences in the dynamic characteristics of autonomic function between normal and diseased conditions may lead to a better understanding of the role of autonomic function imbalance in diseased conditions, and should have important clinical diagnostic and prognostic applications. Another active research area is the development of computational modeling approaches to understand differences in dynamics of renal autoregulatory mechanisms between normotensive and hypertensive conditions. For both areas of research, we are developing novel linear and nonlinear signal processing techniques that can be successfully applied to experimental data to achieve the research objectives.

Fig. 1 Time-varying Impulse Response Functions of Renal Blood Flow: Normotensive (Top Panel) and Hypertensive Rats (Bottom Panel).

Education

  • Ph.D. - Biomedical Engineering, University of Southern California, Los Angeles, California, 1993
  • M.S. - Electrical Engineering (Signal Processing), University of Southern California, Los Angeles, California, 1991
  • M.S. - Biomedical Engineering, University of Iowa, Iowa City, Iowa, 1988
  • B.S. - Electrical Engineering, University of Connecticut, Storrs, Connecticut, 1985

Professional Experience

  • 2007-present Professor, Department of Biomedical Engineering, Stony Brook University
  • 2002-2007 Associate Professor, Department of Biomedical Engineering, Stony Brook University
  • 2002 (January 1) Associate Professor, Dept. of Electrical Engineering, City College of New York, New York, NY.
  • 2002 (September 1) Early tenure granted. City College of New York, New York, NY.
  • 1998-2001 Assistant Professor, Dept. of Electrical Engineering, City College of New York, New York, NY.
  • 1997-1998 Research Assistant Professor, Dept. of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI.
  • 1994-1997 National Research Service Individual Postdoctoral Fellowship Award from the National Institute of Health Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA.
  • 1993-1994 Postdoctoral Associate, Dept. of Biomedical Engineering, University of Southern California, Los Angeles, CA.
  • 1989-1993 Research Assistant, Biomedical Simulations Resource, University of Southern California, Los Angeles, CA.
  • 1990-1993 Research Associate, Cedars-Sinai Medical Center, Division of Pulmonary Physiology, Los Angeles, CA.
  • 1987-1988 Graduate Research Assistant, University of Iowa, Iowa City, IA.
  • 1987-1988 Research Assistant, University of Iowa Hospital & Clinics, Department of Neuro-Ophthalmology.

Grants

Past Grants

  • 1994-1997 National Institute of Health: Individual National Research Service F32 HL009029 ($81,200)
    Title: Nonlinear Analysis-Cardiovascular Regulatory Mechanisms.
    PI: K. H. Chon
     
  • 1997-1999 National Kidney Foundation: Young Investigator Grant ($50,000)
    Title: Estimation of the Dynamic Characteristics of the Intra- and Inter-Nephron Interactions Between the Myogenic and TGF Mechanisms.
    PI: K. H. Chon
     
  • 1998-2001 The Whitaker Foundation: Biomedical Research Grant ($210,000)
    Title: Nonlinear Analysis of Cardiovascular Autonomic Nervous System: Detection and Comparison of Sympathovagal Balance in Healthy and Diseased Conditions.
    PI: K. H. Chon
     
  • 2000-2002 PSC-CUNY faculty research award ($7,652)
    Title: Predictive Methods for Sudden Cardiac Death.
    PI: K. H. Chon

Active Grants

  • 2000-2002 C-One Tech, Inc.
    Title: Development of Medical Devices for Heart Failure Monitoring and Analysis
    Dates of entire project: 4/1/00-3/1/02.
    The objective of this proposal is to develop a novel cardiac device for monitoring heart failure and other cardiac related disease.
    K. H. Chon, P.I. (10% effort).
     
  • 2001-2003 National Institute of Health R21 RR15217-01
    Title: Developing Predictive Methods for Sudden Cardiac Death
    Dates of entire project: 6/1/01 - 5/31/03.
    The objective of this proposal is to develop a new iterative n-step ahead stochastic nonlinear time series algorithm that can be applied to clinical cardiac arrhythmias to obtain the most accurate prognostic information as to whether or not a patient will be susceptible to sudden cardiac death.
    K. H. Chon, P.I. (20% effort).
     
  • 2001-2005 National Institute of Health R01 HL 069629-01
    Title: Decoupling of the Principal Renal Autoregulatory Mechanisms
    Dates of entire project: 8/21/01-8/20/05.
    The objective of this proposal is to develop and test a block-structured mathematical model that will be able to emulate the observed functional behavior of the renal autoregulatory mechanisms under both normotensive and hypertensive conditions.
    K.H. Chon, P.I. (50% effort).

Planned Grants

  • 2002 National Institute of Health R21
    Title: Development of a Time-Varying Transfer Function Algorithm for Physiological System Modeling.
     
  • 2003 American Heart Association (Grant-in-Aid)
    Title: Separation of Sympathetic and Parasympathetic Nervous Systems Using Principal Dynamic Modes.

Publications

Click here to search Ki Chon's PubMed listings

Recent Refereed Journal Publications

Book Chapters

  • Holstein-Rathlou, N.H., K.H. Chon, D.J. Marsh and V.Z. Marmarelis: Model of renal blood flow autoregulation, in: Modelling the Dynamics of Biological Systems, edited by E. Mosekilde and O.G. Mouritsen, pp. 167-185, Springer-Verlag Press, Berlin, 1995.
     
  • Chon, K.H., N.H. Holstein-Rathlou, D.J. Marsh and V.Z. Marmarelis: Parametric and nonparametric nonlinear modeling of renal autoregulation dynamics, In: Advanced Methods of Physiological System Modeling, Vol. III, edited by V.Z. Marmarelis, pp. 195-210, Plenum Press, New York, 1994.

 

  
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