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Michael Hadjiargyrou 

Associate Professor, Associate Vice President for Research
 

On This Page :

  Research Focus
  Education
  Professional Experience
  Honors
  Funding
  Publications
  PubMed listings
  Patents
  Courses
   
   
  Related Labs + Depts
  Orthopaedics
  Genetics
    

 

  Contact Info
 


Michael Hadjiargyrou

T: 631.632.1480
F: 631.632.8577
E: Michael.Hadjiargyrou
@sunysb.edu

 
Office:
Psychology A Room 338
Stony Brook, NY
11794-2580

   

 

 

 

Research Focus

The overall goal of this laboratory is to implement innovative approaches for engineering new skeletal tissue utilizing knowledge derived from molecular/cellular biology and biomaterials. More specifically, we are actively involved in understanding the molecular mechanisms that underlie the wound healing (fracture repair) process. The repair of a fractured bone is a complex biological event that essentially recapitulates embryonic development and requires the orchestration of a number of different cell types undergoing proliferation, migration, adhesion and differentiation, all under the direct control of a host of different genes. Understanding the temporal and spatial expression of these genes during the progression of a healing callus will ultimately enable us to comprehend the essential processes of inflammation, chondrogenesis, ossification, and remodeling. The latest methods in molecular/cellular biology are applied in the pursuit of gene discovery, gene structure and function analysis, expression studies and functional perturbations. By identifying and studying genes that play essential roles during the healing process, we hypothesize that this knowledge will facilitate a greater understanding in our ability to elucidate the process of bone development and regeneration and identify ideal gene candidates for possible therapeutic intervention via the use of biomaterials.

Fig. 1. cDNA microarray analysis. Images of the same area from two microarray filters following hybridization with radioactively labeled RNA obtained from intact bone and PF day 10. Arrows indicate the varying signal intensity between the same spots on each membrane, indicating differential gene expression.

 

Education

  • B.A. - Biology/Philosophy, City University of New York, New York City, 1986
  • M.A. - Biology, City University of New York, New York City, 1988
  • Ph.D. - Molecular Biology, City University of New York, New York City, 1992
  • Post-Doc - Cell/Molecular Biology, California Institute of Technology, Pasadena, CA, 1992-96

Research and Professional Experience

  • 1984 Student researcher, Rusk Institute of Rehabilitation, New York University Medical Center
  • 1984 - 86 Student researcher, Laboratory of Clinical Microbiology and Immunology, Rockefeller University
  • 1987-88 Laboratory Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-91 Recitation Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-92 Graduate student, Department of Biological Sciences, Hunter College, CUNY
  • 1992-95 Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1995-96 Senior Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1996-98 Research Assistant Professor, Department of Orthopaedics and Program in Biomedical Engineering, State University of New York at Stony Brook
  • 1998-2003 Assistant Professor, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2000-present Faculty Member, Graduate Program in Genetics, State University of New York at Stony Brook
  • 2003-present Associate Professor, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2005-2007 Graduate Program Director, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2007- present Associate Vice President for Research, State University of New York at Stony Brook
  • 2007-present Member, Advocacy Committee, American Society for Bone and Mineral
    Research, Washington, DC
  • 2007-present Associate Editor, Journal of Biomedical Nanotechnology

Honors

  • 1984 New York University Medical Center, DeWitt Wallace Reader's Digest Fellow
  • 1986 City University of New York, The Presidential Prize for Academic Excellence in Philosophy
  • 1988-91 City University of New York, Graduate Teaching Fellowship
  • 1989 City University of New York, The Beatrice Goldstein Konheim Graduate Scholarship in the Life Sciences
  • 1990 Hellenic University Club of New York,The Frederick E.G. Valergakis Award
  • 1992-93 California Institute of Technology, American Heart Association Research Fellowship
  • 1993-96 California Institute of Technology, NIH NRSA
  • 2001 Outstanding Teacher of the Year, Department of Biomedical Engineering, SUNY at Stony Brook
  • 2002 Who's Who in Engineering Education
  • 2002 Who's Who in Medicine and Healthcare
  • 2003 Who's Who in America
  • 2003 Who's Who in Science and Engineering
  • 2003 Outstanding Teacher of the Year, Department of Biomedical Engineering, SUNY at Stony Brook
  • 2004 Most Cited Paper Award, Journal of Controlled Release
  • 2005 First Patent Honoree, Research Foundation of New York
  • 2007 Outstanding Service Award, Department of Biomedical Engineering, SUNY at Stony Brook

Membership in Professional Societies

  • 1993-1996 Member, Society for Neuroscience
  • 1997-present Member, American Society for Bone and Mineral Research
  • 1997-present Member, Federation of American Societies for Experimental Biology
  • 2001-present Member, Biomedical Engineering Society
  • 2001-2005 Member, American Society for Cell Biology
  • 2002-2005 Member, American Society for Biochemistry and Molecular Biology

Funding Sources

  • National Institutes of Health
  • National Aeronautics and Space Administration
  • Aircast Foundation
  • New York Center for Advanced Technology

Publications

Click here to search Michael Hadjiargyrou's PubMed listings

Research Articles:

  • Liang, D., Luu, Y.K., Kim, K., Hsiao, B.S., Hadjiargyrou, M. and Chu, B. (2005) In Vitro Non-viral Gene Delivery with Nano-fibrous Scaffolds. Nucl. Acids Res. 33:e170.
  • Chu, B., Liang, D., Hadjiargyrou, M. and Hsiao, B.S. (2006) A new pathway for developing in-vitro nanostructured non-viral gene carriers. J. Phys: Condens. Matter 18:S2513–S2525.
  • Liu, C. and Hadjiargyrou, M. (2006) Identification and Characterization of the Mustang Promoter: Regulation by AP-1 during Myogenic Differentiation. Bone 39:815-824.
  • Komatsu, D., Bosch-Marce, M., Semenza, G.L. and Hadjiargyrou, M. (2007) Enhanced Bone Regeneration Associated with Decreased Apoptosis in Mice with Partial HIF-1a Deficiency. J. Bone Miner. Res. 22:366-374.

  • Chiu, J., Liu, C., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2007) Functionalization of Poly(L-lactide) (PLLA) Nanofibrous Scaffolds with Bioactive Collagen Molecules. J. Biomed. Mater. Res. A 83:1117-27

  • Zhi, J., Xu, G., Rubin, C.T. and Hadjiargyrou, M. (2008) The lipogenic gene Spot 14 is activated in bone by disuse, yet remains unaffected by mechanical signals anabolic to the skeleton (Calcif Tissue Int. 2008 Jan 25 [Epub ahead of print]

Book Chapters/Reviews:

  • Hadjiargyrou, M., McLeod, K.J., Ryaby J.P. and Rubin, C.T. (1998). Enhancement of fracture healing by low intensity ultrasound. Clin. Ortho. Rel. Res. 355S: S216-S229.
     
  • Rubin,CT., Bolander, M., Ryaby, JP., and Hadjiargyrou, M. (2001). The use of low intensity ultrasound to accelerate the healing of fractures. J. Bone Joint Surg. 83:259-270.
     
  • Sommerfeldt, D.W., Hadjiargyrou, M., Rubin, J., and Rubin, C.T. (2002) Clinical Implications of Recent Advances in the Biology and Physiology of Bone (Chapter 1). In Vertebral Osteoporotic Compression Fractures. Marek Szpalski and Robert Gunzburg, Editors. Lippincott Williams & Wilkins, Philadelphia, PA.
     
  • Hadjiargyrou, M. (2002) Reproduction & Development. The Second Creation: Dolly and the Age of Biological Control. The Quarterly Review of Biology 77:202-203.
     
  • Chiu, J., Luu, Y.K., Fang, D., Hsiao, B., Chu, B. and Hadjiargyrou, M. (2005) Electrospun nanofibrous scaffolds for biomedical applications. J. Biomed. Nanotech. 1:115-132.
     
  • Rubin, C.T., Qin, Y. X., Hadjiargyrou, M. and Judex, S.  (2005). Bone’s “Preferred Strain History” Provides Insight into a Proposed Common Pathway for the Stimulation of Bone Formation by Distinct Biophysical Signals (Chapter 5). In Physical Regulation of Skeletal Repair. Roy K. Aaron and Mark Bolander, Editors.  American Academy of Orthopaedic Surgeons, Rosemont, IL.

Selected Abstracts (2002-present):

  • Judex, S., Qin, Y-X., Garman, R., Squire, M., Rubin, C., Hadjiargyrou, M. (2002) Searching for Wolff’s law: The anabolic potential of low level mechanical signals. J. Musculoskel. Neuron. Interact. 2:364-367.
     
  • Hadjiargyrou, M. and Rubin, C.T. (2002) Enhancement of fracture healing by low intensity ultrasound. SICOT/SIROT XXII World Congress. August 23-30, p. 129.
     
  • Sommerfeldt, D.W., Priemel, M., Wang, X., Amling, M., Schinke, T.M., Hadjiargyrou, M., Mansour, S.L., Rueger, J.M. (2002) Increased bone mass in proline-rich transcript of the brain (prtb)-deficient mice. JBMR 17:S181.
     
  • Lombardo, F., Joo, J., White, D.W., Ahn, H., Rubin, C.T. and Hadjiargyrou, M. (2002) Insight into the molecular complexity of fracture repair. JBMR 17:S225.
     
  • Squire, M.E., Donahue, L.R., Hadjiargyrou, M., Rubin, C. and Judex, S. (2002) Mechanically Related Changes in Gene Expression Using Real Time RT-PCR. JBMR 17:S330.
     
  • Kim, K., Yu, M., Zhong, S., Chiu, J., Fang, F., Seo, Y.S., Hsiao, B.S, Chu, B. and Hadjiargyrou, M. (2002) Controlled degradation of electrospun Poly(DL-lactide) nanofiber membranes. American Chemical Society Polymer Chemistry Proceedings. Boston, MA, August 18-22.
     
  • Chiu, J., Kim, K., Zhong, S., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2002) Development of a cell-delivery vehicle derived from electrospun non-woven nanostructured membranes. BMES:197.
     
  • Luu, Y.K., Kim, K., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2002) Characterization of an Electrospun Poly(lactide co-glycolide) and Block Copolymer-based, Nanostructured Matrix for DNA Delivery. BMES:171.
     
  • Rana, S. and Hadjiargyrou, M. (2002) Identification of a novel gene isolated from a fracture callus. BMES:184.
     
  • Lombardo, F., Komatsu, D., McGovern, S. and Hadjiargyrou, M. (2002) Cloning of a novel gene expressed during osteogenic differentiation in a healing fracture callus. Trans. 49th Orthop. Res. Soc. 26:0487.
     
  • McGovern, S., Ka, A., Lombardo, F. and Hadjiargyrou, M. (2002) Temporal and spatial expression of Hox genes during fracture repair Trans. 49th Orthop. Res. Soc. 26:0491.
     
  • Komatsu, D. and Hadjiargyrou, M. (2003) The temporal and spatial expression of HIF-1a and selected angiogenic factors during bone regeneration. JBMR 18:S304.
     
  • Zhong, N., Gersch, R., Komatsu, D., and Hadjiargyrou, M. (2003) Activation of Wnt signaling pathway during bone regeneration. JBMR18:S305.
     
  • Zhong, N., Squire, M., Donahue, L., Rubin, C., Judex, S., and Hadjiargyrou, M. (2003) Alterations in gene expression as induced by the presence/absence of mechanical loads. JBMR 18:S134.
     
  • Kim, K., Chang, C., Zhong, X., Fang, F., Hsiao, B.S, Chu, B. and Hadjiargyrou, M. (2003) The incorporation of an antibiotic drug in electrospun poly(lactide-co-glycolide) non-woven nanofiber scaffolds. American Chemical Society Polymer Chemistry Proceedings, 44:98-99.
     
  • Liu, C., Zhong, N. and Hadjiargyrou, M. (2003) Identification of MUSTANG-interacting protein found during bone regeneration BMES. 9.P2.65.
     
  • Zhong, N., Squire, M., Donahue, L.R., Rubin, C.T., Hadjiargyrou, M. and Judex, S. (2004) Genetic modulation of molecular events induced by mechanical unloading. Trans. 50th Orthop. Res. Soc. 29:0397.
     
  • Zhong, N., Gersch, R., and Hadjiargyrou, M. (2004) Dishevelled is required for chondrocyte proliferation and differentiation. JBMR19:S34.
     
  • Komatsu, D., Manalo, D.J., Semenza, G.L. and Hadjiargyrou, M. (2004) Enhanced bone regeneration in HIF-1a +/- mice. JBMR19:S118.
     
  • Hui, P., Chen, H.C., and Hadjiargyrou, M. (2004) Cloning and differential expression analysis of three novel genes expressed during bone healing. BMES:684.
     
  • Liu, C. and Hadjiargyrou, M. (2005) Identification and Characterization of the Mustang Gene Promoter. JBMR20:S112.
  • Komatsu, D., Bosch-Marce, M., Semenza, G.L. and Hadjiargyrou, M. (2006) Enhanced Bone Regeneration Associated with Decreased Apoptosis in Mice with Partial HIF-1a Deficiency. JBMR 21:S339.
  • Liu, C., Kronenberg, MS., Jiang, X., Rowe, DW. and Hadjiargyrou, M. (2006) Generation of MustangPRO-GFPtpz Transgenic Mice for Studying Musculoskeletal Cell Lineages JBMR 21:S338.
  • Gersch, RP. and Hadjiargyrou, M. (2006) Functional Perturbation of Mustang in Chondrocytes JBMR 21:S336.   
  • Liu, C., Kronenberg, MS., Jiang, X., Rowe, DW. and Hadjiargyrou, M. (2007) Characterization of Mustn1PRO-GFPtpz Transgenic Mice. Proceedings, 33rd Annual Northeast Bioengineering Conference, p. 13.
  • Gersch, RP. and Hadjiargyrou, M. (2007) The Characterization of Mustang in Chondrogenesis in vitro. Proceedings, 33rd Annual Northeast Bioengineering Conference, p. 12. 
  • Hadjiargyrou, M. (2008) Biomimetic electrospun scaffolds for tissue engineering. American Association of Anatomists, Experimental Biology (In press).
     

Educational Papers/Abstracts:

  • Otter, M.W., McLeod, K.J., Khalsa, P.S., Qin, Y.X., Hadjiargyrou, M. and Bluestein D. Contextual Learning Modules – A New Approach to Bioengineering Education. Proceedings of American Society for Engineering Education Annual Conference June 18-21, 2000.
     
  • Khalsa, P.S., Bluestein, D., Otter, M.W., Qin, Y.X., Hadjiargyrou, M., K McLeod Engineering Methods in Biomechanics: A Contextual Learning Strategy for Biomedical Engineering Pedagogy, Proceedings of the American Society for Engineering Education Annual Conference, June 24 - 27, 2001.  
Other Publications:
  • Hadjiargyrou, M. (1991) “True Communism”, New York Times, letter.
     
  • Hadjiargyrou, M. (1997) “For US Students, History Doesn’t Pay”, New York Times, letter.
     
  • Hadjiargyrou, M. (1999) “NATO’s Attack On a Sovereign Nation”, New York Times, letter.
     
  • Hadjiargyrou, M. (1999) “Buchanan’s New Home”, New York Times, letter.
     
  • Hadjiargyrou, M. (2000) “Eureka! A Key to the Code of Life”, New York Times, letter.
     
  • Hadjiargyrou, M. (2001) “Ashcroft and the Divided Senate”, New York Times, letter.
     
  • Hadjiargyrou, M. (2001) “Did the Gold Medalist Get Extra Help?”, New York Times, letter.
     
  • Hadjiargyrou, M. (2001) “Stem Cells and Delicate Questions”, New York Times, letter.
     
  • Hadjiargyrou, M. (2001) “The War, the Press and bin Laden”, New York Times, letter.
     
  • Hadjiargyrou, M. (2001) “Who Is to Blame in the Mideast?”, New York Times, letter.
     
  • Hadjiargyrou, M. (2002) “How Should U.S. Answer Hate?”, New York Times, letter.
     
  • Hadjiargyrou, M. (2002) “Cloning, Science and Morality”, New York Times, letter.
     
  • Hadjiargyrou, M. (2002) “Not Democrats”, Newsday, letter.
     
  • Hadjiargyrou, M. (2003) “Business as Usual in Brookhaven”, Long Island Section, New York Times, letter.
     
  • Hadjiargyrou, M. (2004) “Road to Cloning: Caution Ahead”, New York Times, letter.
     
  • Hadjiargyrou, M. (2004) “Stem Cells and Moral Questions”, New York Times, letter.
     
  • Hadjiargyrou, M. (2004) “Science and Politics Collide”, Science Times, New York Times, letter.
     
  • Hadjiargyrou, M. (2005) “Bending Our Beliefs”, New York Times, letter.
     
  • Hadjiargyrou, M. (2005) “Funding Grants”, The American Society for Cell Biology Newsletter, letter.
     
  • Hadjiargyrou, M. (2005) “Shrinking Budgets for Research”, Long Island Section, New York Times, letter.
     
  • Hadjiargyrou, M. (2005) “Attack on Iraq was About Lies”, Newsday, letter.
  • Hadjiargyrou, M. (2006) “In Iraq, Deadly signs of Civil War”, New York Times, letter.
  • Hadjiargyrou, M. (2006) “’Frankencotton’, the Debate”, Science Times, New York Times, letter.
  • Hadjiargyrou, M. (2006) “’Geo-Green' in 2008?”, New York Times, letter.
  • Hadjiargyrou, M. (2006) “Reconcilling Proof and Belief”, Science Times, New York Times, letter.
  • Hadjiargyrou, M. (2006) “An Unwelcome Discovery”, Magazine, New York Times, letter.
  • Hadjiargyrou, M. (2006) “Federal Help Essential for Scientific Literacy”, Long Island Section, New York Times, letter.
  • Hadjiargyrou, M. (2007) “The Issue: Who Would Lead Best?”, New York Times, letter.
  • Hadjiargyrou, M. (2007) “Stem Cell Hypocrisy”, New York Times, letter.
  • Hadjiargyrou, M. (2007) “To be Young and Liberal in America”, New
     York Times, letter.
  • Hadjiargyrou, M. (2007) “Good Pig Farming”, New York Times, letter.

  • Hadjiargyrou, M. (2008) “The First Primary: It’s Clinton’s Day”, New York Times, letter.

  • Hadjiargyrou, M. (2008) “Spitzer plan does what feds should do for academia”, Newsday, letter.

  • Hadjiargyrou, M. (2008) “The Nature of Politics”, Science Times, The New York Times, letter.
     

Patents

  • Cell delivery system comprising a fibrous matrix and cells. Patent #6790455.
     
  • Cell Storage and Delivery System. United States Patent #20030054035. (Pending).
     
  • Mustang, a gene and nuclear protein. Patent # 7,238,799.
  • Cell delivery system comprising a fibrous matrix and cells. US Patent (Continuation) #7,323,190. Issued on January 29, 2008.

Courses

  • BME 304 Genetic Engineering
     
  • BME 501 Engineering Principles in Cell Biology
     
  • BME 534 Functional Genomics
     
  • BME 545/HBY530 Cell Physiology and Biophysics
     
  • BGE 691 Readings in Genetics
  • MCS2 Medicine in Contemporary Society