Yingtian Pan 

Associate Professor
 

Research Focus

2D and 3D cross-sectional optical imaging of biological tissue at close to cellular resolution (e.g., 2-10µm) and at depths of 1-3mm can have significant impacts on noninvasive or minimally invasive clinical diagnosis of tissue abnormalities, e.g., tumorigenesis, as well as engineering tissue growth and repair. Laser scanning endoscopes, based on optical coherence tomography (OCT), have been developed and tested on a wide variety of tissues both ex vivo and in vivo. Encouraging results based on animal and human studies show that LSE can provide morphological details correlated well with excisional histology, suggesting its potential for optical biopsy or optically guided biopsy to reduced negative biopsies in clinical practice. Current research of Dr. Pan’s lab is focused on early-stage epithelial cancer detection, diagnosis of cartilage injury and repair, and assessment of engineering tissue growth. In addition, Dr. Pan’s lab studies skin dehydration, geriatric incontinence, fluorescence imaging and light microscopy.

Education

• Postdoc - Medical Laser Center of Luebeck, Germany, 1993 - 1996
• Ph.D. - National Laser Technology Laboratories, China, 1992
• M.Sc. - Huazhong University of Science and Technology, China, 1988
• B.Sc. - Huazhong University of Science and Technology, China, 1985

Professional Experience

• 2004 – present Associate Professor, Department of Biomedical Engineering, State University of New York (SUNY) at Stony Brook, Stony Brook, NY
• 2002 – 2004 Assistant Professor, Department of Biomedical Engineering, State University of New York (SUNY) at Stony Brook, Stony Brook, NY
• 2001 – 2002 Assistant Professor of Biomedical Engineering, McGowan Center for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
• 1999 – 2002 (Tenure Track) Assistant Professor of Medicine & Biomedical Engineering, Univ. of Pittsburgh, and Principal Investigator, Science & Technology Center, Carnegie Mellon University
• 1996 – 1999 Senior Imaging Scientist (OCT project leader), (NSF) Center for Light Microscope Imaging & Biotechnology, Carnegie Mellon University, Pittsburgh, PA
• 1992 – 1995 Postdoctoral Scientist, (German national) Medical Laser Center of Luebeck, Medical University of Luebeck, Luebeck, Germany
• 1991 – 1992 Assistant Professor of Applied Optics, National Laser Technology Laboratories, Huazhong University of Science and Technology, Wuhan, China

Honors

• 2002 – 2005 Panel review for NIH study sections (NCI, NIBIB), NIH, Bethesda
• Research/paper reported by other Journal: “Fluorescence Prescreen Enhances OCT Cancer Identification,” Biophotonics Intl., 11(2), (2004)
• Research/paper reported by other Journal: “Using OCT to probe deeper,” Optics & Photonics News, July: 11 (2003)
• Research/paper reported by other Journal: “Biomorph mirror helps capture biological tissue images,” Laser Focus World, 38(3): 42-43 (2002)
• Research/paper reported by other Journal: “OCT distinguishes cancer from precancer,” Biophotonics Intl., 10(2): 64-65 (2002)
• 2002 Sylvia Sorkin Greenfield Best Paper Award, American Association of Physicists In Medicine
• 2000 - 2002 Panel review for NSF BioPhotonics Partnership program, NSF, DC
• 2002 Director, DARPA/DSO workshop: "New BioImaging Techniques for Self Diagnosis"
• 2001 Panel review for NSF BioPhotonics Partnership program
• 2000 Scientific Advisory Committee, SPIE BioPhotonics Conference' 2000, Nov. 8-10, Beijing, China
• 2000 Panel review for NSF BioPhotonics Partnership program
• 1998 Co-chair: Coherence-Domain/Holographic Imaging Techniques Symposium, Biomedical Engineering Society (BMES) Annual Meeting, October 10-13, Cleveland
• 1997 Recipient: Outstanding Researcher, granted by The National Science Foundation through a refereeing process
• 1994 – Biophysical Society, Int'l Society of Photo-Optical Instrumentation Engineers, American Association for the Advancement of Science, American Society of Engrg. Education
• 1994 Guest Professor: National Laser Technology Laboratories, China
• 1992 – 1996 MLL Fellowship: Medical Laser Center of Luebeck, Germany
• 1992 Recipient: Best PhD Thesis Award, awarded by the Chinese High Education Committee
• 1992 – Invited review for: Applied Optics, J. of Optical Society of America A, Optics Letters, Journal of Biotechnology Progress, IEEE Trans on Magnetism, Optical Engineering.
• 1992 Graduated with highest honest (summa cum laude) from the National Laser Technology Laboratories, China
• 1991 Recipient: H. G. Scholarship, awarded to graduate students in science and engineering for "Excellence in Doctorate Study"

Grants

• 07/04 - 06/08 NIH - National Institutes of Health (NIDDK) 2R01-DK059265 PI
  "NONINVASIVE DETECTION OF EARLY BLADDER CANCERS"
  
• 09/04 - 08/08 NIH - National Institutes of Health (NIDDK) R01-DK068401 CoPI
  "Wound Repair by Stimulation of Specific Tissue Ingrowth"
  
• 09/04 - 08/05 Whitaker Foundation - Biomedical Engineering Transitional Research Grant PI
  "Fluorescence-Image-Guided OCT Endoscopy for Noninvasive Diagnosis of Bladder Tumors: System Development "
  
• 12/01 - 11/03 US Army (DARPA/DSO) - Defense Advanced Research Project PI
  "Development of Noninvasive Medical Imaging Techniques For Field Uses: Phase 1"
  
• 04/01 - 03/04 NIH - National Institutes of Health (NIDDK) R01-DK059265-01 PI
  "NONINVASIVE DETECTION OF UROTHELIAL ABNORMALITIES"
  
• 08/01 - 07/02 Pittsburgh Tissue Engineering Initiative - Technology Development Fund PI
  "High-Resolution Optical Arthroscopy for Noninvasive or Minimally Invasive Diagnosis of Small Hard Tissue Lesions" Active
  
• 09/00 - 08/04 Whitaker Foundation - Biomedical Engineering Research Grant PI
  "Cystoscopic Optical Coherence-Domain Imaging for Noninvasive Diagnosis of Urinary Bladder Tumors: System Development "
  
• 09/00 - 08/02 University of Pittsburgh Medical Center - CMRF PI
  "Noninvasive Detection of Bladder Tumors Using Optical Coherence Tomography: Preliminary Study" Active
  
• 11/00 - 12/01 Carnegie Mellon University - New Technology Seed Grant PI
  "Noninvasive Monitoring of Bone Regeneration"
  
• 03/96 - 09/99 Carnegie Mellon University - Unilever US Research & Development Co-PI
  "Noninvasive and in vivo Imaging of Human Skin Functions Completed

Patent Applications

• Y. -T. Pan, "Fiberoptic Mach-Zehnder interferometer based polarization-sensitive optical coherence imaging devices," submitted to University of Pittsburgh Technology Transfer Office, 02/2000.
  
• Y. -T, Pan, G. Fedder, H. Xie, F. Campbell, “An endoscopic laser scanning imaging device based on a MEMS micromirror,” submitted in 09/2001, patent pending.
  
• Y. -T, Pan, Z. G. Li, C. Chu, “Arthroscopic Optical Coherence Tomography,” patent application, 2002.

Publications

Books

• Y. -T. Pan and X. -D Liu: Magneto-Optics In Magnetic Fluids, (in Chinese) University Press, Huazhong University of Science and Technology, Wuhan, China, (2000).

Journal Publications

• T. Q. Xie, Z. G. Wang, & Y. T. Pan, "Dispersion compensation in high-speed optical coherence tomography using acousto-optic modulation," Appl. Opt. accepted (2005)
  
• C. -W. Du, Y. T. Pan, G. A. MacGowan, A. P. Koretsky, “Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filtering,” Cell Calcium, 35: 141-153 (2004)
  
• C. R. Chu, D. Lin, J. L. Geisler, C. T. Chu, F. H. Fu, Y. T. Pan, "Arthroscopic Microscopy of Articular Cartilage Using Optical Coherence Tomography," AJSM, 32: 699-709 (2004)
  
• A. Jain, H. Xie, Y. T. Pan, G. Fedder, “A Two-Axis Electrothermal Micromirror for Endoscopic Optical Coherence Tomography,” IEEE J. of Selected Topics in Quantum Electronics, 10:636-642 (2004)
  
• Y. T. Pan, T. Q. Xie, and Z. G. Wang, “Detection of Bladder Tumorigenesis Using Optical Coherence Tomography,” SPIE 5316: 56-61 (2004)
  
• T. Q. Xie, and Z. G. Wang, Y. T. Pan, “Comparable Study of Optical Coherence Tomography with the wavelength of 940nm and 1300nm,” SPIE 5316: 439-443 (2004)
  
• T. Q. Xie, Z. G. Wang, & Y. T. Pan, "High-speed optical coherence tomography using fiber-optic acousto-optic phase modulation," Opt. Express, 11: 3210-3219 (2003)
  
• Y. T. Pan, T. Q. Xie, C. W. Du, S. Bastacky, M. L. Zeidel, “Enhancing early bladder cancer detection with fluorescence-guided endoscopic optical coherence tomography,” Opt. Letts., 28: 2485-87 (2003)
  
• Y. T. Pan, Z. Li, and C. Chu, "Hand-held Arthroscopic Optical Coherence Tomography for In Vivo High-resolution Articular Cartilage Imaging," J. Biomed. Opt., 8: 648-654, (2003)
  
• T. Q. Xie, H. K. Xie, G. K. Fedder, & Y. T. Pan, “Endoscopic Optical Coherence Tomography with a Modified MEMS Mirror,” Elect. Letts., 39: 1535-1536 (2003)
  
• H. -K. Xie, Y. -T. Pan, and G. Fedder, "A CMOS-MEMS Micromirror With Large Out-of-Plane Actuation," J. MEMS, 12 (4): 450-457, (2003)
  
• T. Q. Xie, H. K. Xie, G. K. Fedder, & Y. T. Pan, “Endoscopic Optical Coherence Tomography with a Modified MEMS Mirror for Detection of Bladder Cancers,” Appl. Opt., 42:6422-6426, (2003)
  
• C. Han, C. Chu, N. Adachi, F. Fu, J. Huard, & Y. T. Pan, "Monitoring the healing process in rabbit cartilage post chondrocyte transplantation with OCT," Osteoarthritics & Cartilage,11:111-121, (2003)
  
• H. -K. Xie, Y. -T. Pan, and G. Fedder, “Endoscopic optical coherence tomographic imaging with a CMOS-MEMS micromirror,” Physical A 103: 237-241, (2003)
  
• T. -Q. Xie, Z. -G. Li, M. Zeidel, and Y. -T. Pan, "Optical Imaging Diagnostics of Bladder Tissue with Optical Coherence Tomography," SPIE – 4609: 159-164 (2003).
  
• C. -W. Du, Y. -T. Pan, G. MacGowan, and A. Koretsky, "Separation of calcium transients and motion artifact using frequency filtering of fluorescent signals arising from the perfused mouse heart", SPIE – 4623: 283-286 (2002)
  
• T. -Q. Xie, M. L. Zeidel, and Y. -T. Pan, "Detection of tumorigenesis in urinary bladder with optical coherence tomography: optical characterization of morphological changes," Opt. Ex-press, 10(24), 1431-1443 (2002)
  
• Y. -T. Pan, J. P. Lavelle, S. Bastaky, S. Meyers, D. L. Farkas, and M. Zeidel, "Detection of Tumorigenesis in Rat Bladders with Optical Coherence Tomography," Med. Phys., 28(12): 2432-2440, (2001).
  
• Y. -T. Pan, H. -K. Xie, and G. Fedder, "Endoscopic Optical Coherence Tomography Based on A CMOS-MEMS Micromirror," Opt. Letts., 26(24), 1966-1968, (2001).
  
• Y. -T. Pan, J. Lavelle, S. Bastaky, D. L. Farkas, M. Zeidel, "Noninvasive imaging of biological tissue structure, function, and abnormalities with optical coherence tomography," H. Liu & Q. Luo, eds, Biomedical Photonics and Optoelectronic Imaging, SPIE 4224, p.391-399 (2000)
  
• Y. -T. Pan & D. L. Farkas, " Non-invasive Imaging of Living Human Skin with Dual-wavelength Optical Coherence Tomography in Two and Three Dimensions," Journal of Biomedical Optics, 3 (10), 446-455 (1998), with a 3-D OCT image on cover page.
  
• Y. -T. Pan & D. L. Farkas, "Noninvasive imaging of biological tissue with dual wavelength optical coherence tomography," D. L. Farkas, R. C. Reif & B. J. Tromberg, ed., Optical Investigations of Cells In Vitro and In Vivo, SPIE-3260, 141-149 (1998)
  
• Y. -T. Pan, R. Birngruber, and R. Engelhardt, "Contrast limits of coherence-gated imaging in scattering media," Applied Optics, 36 (13), 2979-2986 (1997)
  
• Y. -T. Pan, E. Lankenau, R. Birngruber, and R. Engelhardt, "In vivo optical coherence-gated imaging of biological tissues," IEEE Journal of Selected Topics in Quantum Electronics, 2 (4), 1029-1034 (1997)
  
• Y. -T. Pan & D. L. Farkas, “In vivo imaging of biological tissues using 1.3 mm optical coherence tomography,” SPIE-2983: 93-100 (1997)
  
• J. Welzel, E. Lankenau, Y. -T. Pan, R. Birngruber, & R. Engelhardt, "Optical coherence tomography of the skin, " In: Elsner P., Berardesca E., Gabard B. Serup S. (eds.): Advances in skin biomedical engineering. Karger, Basel, (1997)
  
• Y. -T. Pan, R. Birngruber, and R. Engelhardt "Optical coherence-gated imaging of biological tissues," SPIE-2678: 165 (1996)
  
• Y. -T. Pan, X. D. Liu & C. W. Du, "Characteristics of magneto-optical effects of magnetic fluid and their applications," AIP transl. (Chin. J.) Acta Optica Sinica. 16 (12): 1725-1729 (1996)
  
• Y. -T. Pan, R. Birngruber, J. Rosperich, and R. Engelhardt, "Optical coherence tomography in turbid tissues: theoretical analysis," Applied Optics, 34 (28): 6564-6574 (1995)
  
• Y. -T. Pan, S. Alrt, R. Birngruber, and R. Engelhardt, "Optical coherence tomography in scattering media: theory and experimental results," SPIE-2628: 239-248 (1995)
  
• Y. -T. Pan, R. Birngruber, J. Rosperich, G. Huetterman, R. Engelhardt, "Measurement of optical-interaction-coefficients of intralipid in visible and NIR range," SPIE-2134: 354-363 (1994)
  
• Y. -T. Pan, C. W. Du, Z. G. Li, X. D. Liu and R. Birngruber, "Monte-Carlo simulation of magneto-birefringence in magnetic fluids," J. Appl. Phys., 73 (10): 6142-6145 (1993)
  
• Y. -T. Pan, C. W. Du, Z. G. Li, X. D. Liu and R. Birngruber, "The wavelength dependence of Faraday effect and magneto-birefringence in ferrofluid thin films," J. Appl. Phys., 73 (10): 6139-6141 (1993)
  
• Y. -T. Pan, X. D. Liu, C. W. Du & Z. G. Li, "Fiber-optic magnetooptical bistable effects in the thin films of magnetic fluids," Soviet J. of Low Temperature Physics, 18: 269-272 (1992)
  
• Y. -T. Pan, X. D. Liu, C. W. Du and Z. G. Li., "An effective correction to the theoretical curve of magneto-birefringence of magnetic fluid," J. Appl. Phys., 71 (8): 3937-3939 (1992)
  
• Y. -T. Pan, X. D. Liu, C. W. Du & Z. G. Li, "Magneto-optical bistability of ferrofluids," AIP transl. Chin. Phys., 12 (1): 132-137 (1992)
  
• Y. -T. Pan, X. Liu, C. W. Du & Z. G. Li, "Longitudinal magneto-optical absorption and rotation in concentrated ferrofluid thin films," Soviet J. of Low Temperature Phys., 18: 273-276 (1992)
  
• Y. -T. Pan, C. W. Du & X. D. Liu, "Microprocessor-based fiber-optic temperature sensor for medical applications," AIP transl. (Chin. J.) Acta Electronica Sinica, 20 (2): 87-91 (1992)
  
• Y. -T. Pan & X. D. Liu, "Magneto-optical properties of dense magnetic fluid and their applications," (Chin. J.) Infrared Technology, 14 (5): 41-45 (1992)
  
• Y. -T. Pan, X. D. Liu, C. W. Du and Z. G. Li, "Fiber-optic magnetic field and current sensor, using magneto-birefringence of dense ferrofluid thin films," Curshaw, ed., Advances in optical fiber sensors, SPIE-1572: 477-482 (1991)
  
• Y. -T. Pan, X. D. Liu & C. W. Du, "Optical bistable effects of magnetic fluid," AIP transl. (Chin. J.) Acta Optica Sinica, 11 (8): 687-692 (1991)
  
• Y. -T. Pan & X. D. Li, "Modified cladding refractive index dependent fiber-optic thermometer for biomedical applications," AIP transl. (Chin. J.) Infrared & Millimeter Waves, 9 (1): 79-86 (1990)
  
• Y. -T. Pan & X. D. Liu, "Thermal sensitive cladding fiber-optic thermometer for biomedical applications," Chin. J. of Infrared Research, 9 (1): 73-80 (1989)

Invited Presentations

• Chu C. R., Studer R. K., Geisler J., Fu F. H., Pan Y. T., “Optical coherence tomography form birefringence is a potential marker of early articular cartilage degeneration,” 5th International Cartilage Repair Society Meeting, Gent Belgium, May 26-29 (2004)
  
• Z. G. Wang, T. Q. Xie, H. K. Xie, and Y. T. Pan, "Detecting bladder cancers with optical coherence tomography," BioPhotonics West ’2004, San Jose, Jan.25-28, (2004)
  
• Y. T. Pan, "Laser Scanning endoscopy for high-resolution biomedical imaging," invited presentation at the Life Science Directorate, Brookhaven National Lab, August 28, 2003
  
• A. Jain, T. Xie, Y. T. Pan, G. K. Fedder, and H. Xie, “A Two-Axis Electrothermal SCS Micromirror for Biomedical Imaging,” 2003 IEEE/LEOS International Conference on Optical MEMS, Waikoloa, HI, August 2003
  
• H. Xie, A. Jain, T. Xie, Y. T. Pan, and G. K. Fedder, “A Single-Crystal Silicon-based Micromirror with Large Scanning Angle for Biomedical Applications,” Conference on Lasers and Electro-Optics (CLEO) 2003, Baltimore, MD, June 2003
  
• Y. T. Pan, "Noninvasive Optical Imaging Diagnosis of Early Bladder Cancers," invited presentation at the Brady Urologic Institute, John Hopkins University, June 06, 2003
  
• Han, C., Pan, Y. T., Chu, C. R., Adachi, N Huard J, Fu, F.H., “Analysis of the Rabbit Articular Cartilage Repair after Chondrocyte Implantation using Optical Coherence Tomography,” International Cartilage Repair Society, Toronto, Canada, June 2002
  
• Y. T. Pan, "Portable Handheld Optical Coherence Tomographic Probes For Field Use," DARPA PIC Meeting, Tampa, September 4-7, 2002.
  
• Y. T. Pan, "Detection of bladder cancer with endoscopic optical coherence tomography," OSA meeting '2002, Miami, April 7-9, 2002.
  
• T. -Q. Xie, Z. -G. Li, M. Zeidel, and Y. -T. Pan, "Optical Imaging Diagnostics of Bladder Tissue Abnormalities," SPIE - BioPhotonics Urology Section, Jan. 19-26, San Jose, CA (2002).
  
• C. -W. Du, Y. -T. Pan, G. MacGowan, and A. Koretsky, "Separation of calcium transients and motion artifact arising from perfused mouse heart," SPIE - BioPhotonics, Jan. 19-25, CA (2002).
  
• Y. -T. Pan, "Optical Imaging Diagnosis of Cytotoxicity In Rabbit Cornea After Biochemical Attacks," invited PI presentation by DARPA/PIC Program, Jan. 7-8, 2002.
  
• Y. -T. Pan, "Noninvasive Optical Imaging Techniques for Field-Use Soldier's Self Diagnosis" invited presentation by DARPA/DSO, April 18, 2001.
  
• Y. -T. Pan, "Noninvasive Optical Imaging Monitoring of Engineering Tissue Growth," invited presentation at the First International Conference on Engineering Tissue Growth '2000, Pittsburgh, March 26-28, 2001.
  
• Y. -T. Pan, "Optical Coherence-gated Imaging," invited presentation at Hsinghua University, Beijing, Nov. 22, 2000.
  
• Y. -T. Pan, "Special Topics on Advanced Biomedical Imaging Techniques," invited presentation at Huazhong University of Science and Technology, Wuhan, Nov. 17, 2000.
  
• Y. -T. Pan, "High-resolution Optical Imaging Diagnosis of Bladder Cancers," invited presentation at the International Conference on Biomedical Optics – China ‘2000, Beijing, Nov. 8-10, 2000.
  
• Y. -T. Pan, "High-Fidelity Optical Coherence Tomography for Noninvasive Biomedical Imaging: Technological Developments," invited presentation by NIH/NIBIB, March 20, 2000.
  
• Y. -T. Pan, "Noninvasive and High-resolution Optical Imaging Diagnosis of Biological Tissue," invited presentation by NIH/NINDS, June 20, 1999.