Analysis and manipulation of the genome, and development
of processes for applying this knowledge in the clinic.
Emphasis is on the discovery of novel genes active in
tissue healing and adaptation as well as the development
of therapeutic drugs, antibodies, vaccines, proteins,
and antisense products for agricultural, environmental
and medical applications.
Current faculty research projects related to Molecular
Biomedical Engineering include:
Dhundale:
- Development of a DNA Microarray facility
Eisenberg:
- Combinatorial aspects of genome analysis
Entcheva:
- Mechanisms of cardiac arrhythmias, defibrillation
- Modulation of cell function through gene transfer
Hadjiargyrou:
- Transcriptional profiling of bone regeneration
- Molecular/Functional characterization of genes involved
in skeletal development repair and adaptation
Judex:
- Molecular events involved in bone's response to
changes in its mechanical environment
- Influence of genetic variations on bone's sensitivity
to mechanical stimuli
McCombie:
- Correlation of structure and function in complex
genomes
Neuwald:
- Development of new statistical and algorithmic methods
with application in the classification and modeling
of protein domains
Rubin:
- Functional genomics in the musculo-skeletal system
Skiena:
- Computational geometry, algorithms, discrete mathematics
Stein:
- Genome database development
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