Lab Publications (2002-present)


Journal Articles

  1. Burton RAB, Klimas A, Ambrosi CM, Tomek J, Corbett A, Entcheva E, Bub G. Optical control of excitation waves in cardiac tissue. Nature Photonics, Advanced Publication. doi:10.1038/nphoton.2015.196. 2015. [PDF]

  2. Yu J, Chen K, Lucero RV, Ambrosi CM, Entcheva E. Cardiac Optogenetics: Enhancement by All-Trans-Retinal. Scientific Reports. 2015. (in press).

  3. Boyle PM, Karathanos TV, Entcheva E, and Trayanova NA. Computational modeling of cardiac optogenetics: Methodology overview and review of findings from simulations. Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2015.04.036. 2015 (in press).[PDF]

  4. Williams JC and Entcheva E. Optogenetic versus Electrical Stimulation of Human Cardiomyocytes: Modeling Insights. Biophysical Journal, doi:10.1016/j.bpj.2015.03.032. 2015. [PDF]


  5. Software Downloads:
    Code 1: ChR2 Voltage-Clamp Model (Williams et al. 2013)
    Code 2: ChR2 in Human Epicardial Ventricular Cardiomyocyte (ten Tusscher et al. 2006)
    Code 3: ChR2 in Human Epi/Endo/Mid Ventricular Cardiomyocyte (O'Hara et al. 2011)
    Code 4: ChR2 in Human Atrial Cardiomyocyte (Courtemanche et al. 1998)
    Code 5: ChR2 in Human Purkinje Fiber (Sampson et al. 2010)
    Code 6: ChR2 in Giant Squid Axon (Clay et al. 2008)


  6. Entcheva E. A step closer to cardiac optogenetics in vivo. (invited editorial), Cardiovascular Research, 106 (2):180-1. doi: 10.1093/cvr/cvv116. 2015. [PDF]

  7. Klimas A and Entcheva E. Towards microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective. Journal of Biomedical Optics, doi:10.1117/1.JBO.19.8.080701, 2014. [PDF]

  8. Entcheva E and Williams JC. Channelrhodopsin2 current during the action potential: "Optical AP clamp" and approximation. Scientific Reports, doi:10.1038/srep05838, 2014. [PDF]

  9. Ambrosi CM, Klimas A, Yu JZ, and Entcheva E. Cardiac applications of optogenetics. Progress in Biophysics & Molecular Biology, doi: 10.1016/j.pbiomolbio.2014.07.001, 2014. [PDF]

  10. Ambrosi CM and Entcheva E Optogenetic control of cardiomyocytes via viral delivery. Methods in Molecular Biology, 1181, doi: 10.1007/978-1-4939-1047-2_19, 2014.

  11. Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ. Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure, Journal of the American Heart Association, PMID: 24958777, 3(3):e000527, 2014. [PDF]

  12. Entcheva E. Fiat lux in understanding cardiac pacing, resynchronization and signaling by way of optogenetics, (invited editorial), Cardiovascular Research, PMID: 24760549, 102(3):342-3, 2014. [PDF]

  13. Ambrosi CM and Entcheva E. Optogenetics' promise: pacing and cardioversion by light? Future Cardiol., 2014 Jan;10(1):1-4. [PDF]

  14. Boyle PM, Entcheva, E, and Trayanova NA. See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort? Expert Rev Cardiovasc Ther., 2014 12(1): 17-20. [PDF]

  15. Williams JC, Xu J, Lu Z, Klimas A, Chen X, Ambrosi CM, Cohen IS, and Entcheva E. Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model, PLoS Computational Biology, 2013 Sep;9(9):e1003220. (Open Access)

    Software Downloads:


  16. Boyle PM, Williams JC, Ambrosi CM, Entcheva E, Trayanova NA. A comprehensive multiscale framework for simulating optogenetics in the heart, Nature Communications, 2013 Aug 28;4:2370. [PDF; Supplementary Information]

  17. Entcheva E. Cardiac Optogenetics. Am J Physiol Heart Circ Physiol., 2013 May;304(9):H1179-91. [ PDF]

  18. Entcheva E. Integration of optical stimulation with high-resolution optical imaging of cardiac tissue, Microscopy & Analysis, 27(1): D4, 2013.

  19. Lu J, Wang HZ, Jia Z, Zuckerman J, Lu Z, Guo Y, Boink GJ, Brink PR, Robinson RB, Entcheva E, Cohen IS. Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy, J Cardiovasc Pharmacol., 60(1):88-99, July 2012.

  20. Boink GJ, Lu J, Driessen HE, Duan L, Sosunov EA, Anyukhovsky EP, Shlapakova IN, Lau DH, Rosen TS, Danilo P, Jia Z, Ozgen N, Bobkov Y, Guo Y, Brink PR, Kryukova Y, Robinson RB, Entcheva E, Cohen IS, and Rosen MR. Effect of SkM1 sodium channels delivered via a cell platform on cardiac conduction and arrhythmia induction, Circ Arrhythm Electrophysiol., 21 June 2012.

  21. Jia Z, Bien H, Shiferaw Y and Entcheva E, Cardiac cellular coupling and the spread of early instabilities in intracellular Ca2+, Biophysical Journal, 102(6):1294-302, 2012. [ PDF]

  22. Jia Z, Valiunas V, Lu Z, Bien H, Wang HZ, Liu H, Rosati B, Brink, PR, Cohen IS and Entcheva E, Stimulating cardiac muscle by light: cardiac optogenetics by cell delivery,Circulation: Arrhythmia & Electrophysiology, 4(5):753-60, 2011. [PDF]

  23. Wu, CY, Jia Z, Wang W, Ballou LM, Jiang YP, Chen B, Mathias RT, Cohen IS, Song LS, Entcheva E, and Lin RZ, PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes, PLoS One, 6(9):e24404, 2011.

  24. Quinn TA,.....,Entcheva E,..... Kohl P, Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing, Prog Biophys Mol Biol, 107(1):4-10, 2011.

  25. Leigh S, Tattu A, Mitchell JSB and Entcheva E, M3: Microscope-based Maskless Micropatterning with Dry-Film Photoresist, Biomedical Microdevices, 13(2):375-81, 2011.

  26. Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B and Entcheva E, Hypetrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization, FASEB Journal, 25(3):851-62, 2011.

  27. Horning M, Isomura A, Jia Z, Entcheva E, Yoshikawa K, Utilizing the eikonal relationship in strategies for reentrant wave termination in excitable media. Phys Rev E, 81(5): 056202, 2010.

  28. Shah U, Bien H, and Entcheva E, Microtopographical effects of natural scaffolding on cardiomyocyte function and arrhythmogenesis. Acta Biomaterialia, 6(8):3029-34, 2010.

  29. Wang W, Gao J, Entcheva E, Cohen IS, Mathias RT, A transmural gradient in the cardiac Na/K pump generates a transmural gradient in Na/Ca exchange. J Membrane Biology, 233(1-3):51-62, 2010.

  30. Jia Z, Bien H, and Entcheva E, Detecting space-time alternating biological signals close to the bifurcation point.IEEE Trans Biomedical Eng, 57(2):316-24, 2010.

  31. Lu Z, Jiang YP, Wang W, Xu XH, Mathias RT, Entcheva E, Ballou LM, Cohen IS and Lin RZ, Loss of cardiac phosphoinositide 3-kinase p110a results in contractile dysfunction, Circulation , 120(4):318-25, 2009.

  32. Bartocci E, Corradini F, Di Berardini MR, Entcheva E, Smolka SA, and Grosu, R, Modeling and simulation of cardiac tissue using hybrid I/O automata, Theoretical Computer Science, 410(33-34):3149-3165, 2009.

  33. Grosu R, Smolka SA, Corradini F, Wasilewska A, Entcheva E, Bartocci E, Learning and detecting emergent behavior in networks of cardiac myocytes, Communications of the ACM, 52(3):97-105,  2009.

  34. Entcheva E and Bien H, Mechanical and spatial determinants of cytoskeletal geodesic dome formation in cardiac fibroblasts. Integrative Biology, 1(2):212-219, 2009.

  35. Protas L, Dun W, Jia Z, Lu J, Bucchi A, Kumari S, Lu Z, Chen M, Cohen IS, Rosen MR, Entcheva E, and Robinson RB, Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium, Cardiovascular Research, 81(3):528-535, 2009.

  36. Grosu R, Bartocci E, Corradini F, Entcheva E, Smolka SA, Wasilewska A, Learning and detecting emergent behavior in networks of cardiac myocytes, LNCS: Lecture Notes in Computer Science, 4981:229-243, 2008.

  37. Bartocci E, Corradini F, Entcheva E, Grosu, R, Smolka SA, CellExcite: A tool for simulating excitable cells, BMC Bioinformatics, 9, Suppl 2:S3, 2008.

  38. Ye P, Grosu R, Smolka SA, and Entcheva E, Formal analysis of abnormal excitation in cardiac tissue, LNBI: Lecture Notes in Bioinformatics, 5307:141-155, 2008.

  39. Bartocci E, Corradini F, Di Berardini MR, Entcheva E, Grosu R, Smolka SA. Spatial I/O hybrid automata for excitable tissue modelling. ENTCS: Electronic Notes in Theoretical Computer Science, 194:51-67, 2008.

  40. Ye P, Entcheva E, Smolka SA, and Grosu R. Modeling excitable cells using cycle-linear hybrid automata. IET Systems Biology 2:24-32, 2008.

  41. Chung CY, Bien H and Entcheva E. The role of cardiac tissue alignment in modulating electrical function. Journal of Cardiovascular Electrophysiology 18:1323-1329, 2007.

  42. Grosu R, Mitra S, Ye P, Entcheva E, Ramakrishnan IV, and Smolka SA. Learning cycle-linear hybrid automata for excitable cells. Lecture Notes in Computer Science 4416 , 245-258, 2007.

  43. Bien H, Parikh P, and Entcheva E. Lenses and effective spatial resolution in macroscopic optical mapping. Physics in Medicine and Biology 52(4):941-960, 2007.

  44. Bien H and Entcheva E. Spatial frequency content in optical mapping of cardiac cell monolayers. American Journal of Physiology - Heart and Circ Physiol 291(3):H484-5, 2006.

  45. Bien H, Yin L, and Entcheva E. Calcium instabilities in mammalian cardiomyocyte networks. Biophysical Journal 90: 1-13, April 2006.

  46. Entcheva E and Bien H. Macroscopic optical mapping of excitation in cardiac cell networks with ultra-high spatiotemporal resolution. Progress in Biophysics and Molecular Biology 92(2):232-57, 2006. featured in the December 2006 issue of Biophotonics International

  47. Ye P, Entcheva E, Grosu R, and Smolka SA. Efficient modeling of excitable cells using hybrid automata. Computational Methods in Systems Biology. 2005.

  48. Zong X, Bien H, Chung CY, Yin L, Fang D, Hsiao BS, Chu B, and Entcheva E. Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials. 26: 5330-8, 2005.

  49. Entcheva E and Bien H. Acoustic micromachining of three-dimensional surfaces for biological applications. Lab on a Chip 2005. 5(2): 179-184. "hot article" according to the Royal Society of Chemistry

  50. Yin L*, Bien H*, Entcheva E. Scaffold topography alters intracellular calcium dynamics in cultured cardiomyocyte networks. American Journal of Physiology - Heart & Circulatory Physiology. 283(3): H1276-85, 2004. (*equal contribution)

  51. Entcheva E, Bien H, Yin L, Chung C-Y, Farrell M, and Kostov Y. Functional cardiac cell constructs on cellulose-based scaffolding. Biomaterials. 25: 5753-5762, 2004.

  52. Entcheva E, Kostov Y, Tchernev E, and Tung L. Fluorescence imaging of electrical activity in cardiac cells using an all-solid-state system. IEEE Trans Biomed Eng . 51(2): 333-341, 2004.

  53. Bien H, Yin L and Entcheva E. Cardiac cell networks on elastic microgrooved scaffolds. IEEE Eng Med Biol. 22(5): 108-112, 2003.

  54. Entcheva E and Bien H. Tension development and nuclear eccentricity in topographically controlled cardiac syncytium. J Biomedical Microdevices. 5(2): 165-170, 2003.


  55. Conference Proceedings Short Papers


  56. Yu, J., P. M. Boyle, C. M. Ambrosi, N. Trayanova, and E. Entcheva. 2013. High-throughput contactless optogenetic assay for cellular coupling: Illustration by ChR2-light-sensitized cardiac fibroblasts and cardiomyocytes. In Scientific Sessions fo the American Heart Association, Dallas, TX.

  57. Boyle PM, Williams JC, Entcheva E, and Trayanova NA, A Computational Framework for Simulating Cardiac Optogenetics, Computing in Cardiology, Krakow, Poland, 2012.Young investigator finalist.

  58. Jia Z, Gordon C, Bien H, Brink P and Entcheva E, Enhancement of cell-to-cell coupling with 4-phenylbutyrate (4PB) and its effects on cardiac function , Proceedings of IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009.

  59. Jia Z, Bien H, and Entcheva E, A sensitive algorithm for automatic detection of space-time alternating signals in cardiac tissue, Proceedings of IEEE Engineering in Medicine and Biology Society, Vancouver, Canada, 2008.

  60. Ye P, Grosu R, Smolka SA, and Entcheva E, Formal analysis of abnormal excitation in cardiac tissue, In CMSB: Computational Methods in Systems Biology, Rostock, Germany, October 2008.

  61. Ye P, Entcheva E, Smolka SA and Grosu R. Symbolic Analysis of the Neuron, Proc. of ICBBE'08, the 2nd IEEE International Conference on Bioinformatics and Biomedical Engineering, Shanghai, China, May, 2008.

  62. Grosu R, Bartocci E, Corradini F, Entcheva E, Smolka SA, Wasilewska A, Learning and detecting emergent behavior in networks of cardiac myocytes, HSCC?8-Eleventh International Conference on Hybrid Systems: Computation and Control, St. Louis, MI, 2008.

  63. Bartocci E, Berardini MR, Corradini F, Entcheva E, Grosu, R, Smolka SA, Spatial I/O hybrid automata for excitable tissue modelling, FBTC'2007 ?From Biology to Concurrency and Back, Lisbon, Portugal, 2007.

  64. Bartocci E, Corradini F, Entcheva E, Grosu, R, Smolka SA, CellExcite: A tool for simulating excitable cells, BITS2007 ?Annual Meeting of the Bioinformatics Italian Society, Napoli, Italy, April 2007.

  65. Mitra S, Grosu R, Ye P, Entcheva E, Ramakrishnan IV, Smolka SA, Learning cycle-linear hybrid automata for excitable cells, HSCC?7-Tenth International Conference on Hybrid Systems: Computation and Control, Pisa, Italy, April 2007.

  66. Ye P, Entcheva E, Smolka SA, True M, Grosu R, Cycle-linear approach to modeling action potentials, Proceedings of IEEE Engineering in Medicine and Biology Society, New York City, NY, September 2006.

  67. Ye P, Entcheva E, Smolka SA, True M, Grosu R, Hybrid automata as a unifying framework for modeling cardiac cells, Proceedings of IEEE Engineering in Medicine and Biology Society, New York City, NY, September 2006.

  68. True M, Entcheva E, Smolka SA, Ye P, Grosu R, Efficient event-driven simulation of excitable hybrid automata, Proceedings of IEEE Engineering in Medicine and Biology Society, New York City, NY, September 2006.

  69. Singh R, Bien H and Entcheva E, Inherent dispersion of restitution properties over space, Proceedings of IEEE Engineering in Medicine and Biology Society, New York City, NY, September 2006.

  70. Shah U, Bien H and Entcheva E, Cardiac arrhythmogenesis and temperature, Proceedings of IEEE Engineering in Medicine and Biology Society, New York City, NY, September 2006.

  71. Zong X, Bien H, Chung C-Y, Yin L, Kim K, Fang DF, Chu B, Hsiao BS and Entcheva E. Electrospun non-woven membranes as scaffolds for heart tissue constructs. Fall Meeting of the American Chemical Society, New York, NY, September 2003

  72. Bien H, Yin L, Entcheva E. Optical mapping of complex electrical activity in engineered cardiac tissue constructs. ASME Summer Bioengineering Conference, Sonesta Beach FL, 2003.

  73. Entcheva E., Alseikhan BA, Ianuzzi A, Yue DT, Tung L, Engineering analysis of cardiac electrical activity in response to calmodulin mutations. Proceedings of IEEE Engineering in Medicine and Biology Society and BMES Annual Conference, Houston TX, 2002.

  74. Bien H, Yin L, Entcheva E. Cardiac cell networks on elastic microgrooved scaffolds. Proceedings of IEEE Engineering in Medicine and Biology Society and BMES Annual Conference, Houston TX, 2002.


  75. Conference Abstracts


  76. Ambrosi CA, Chen K, Kalra J, Chen X, Zhu W, Yu JZ, Jiang YP, Lin RZ, Cohen IS, Entcheva E, Spatial distribution of donor cells energy requirements for optogenetic control of the heart, Heart Rhythm Society Meeting, Denver CO, May 2013.

  77. Ambrosi CA, Chen K, Kalra J, Chen X, Zhu W, Yu JZ, Jiang YP, Lin RZ, Cohen IS, Entcheva E, Spatial distribution of the light-sensitive ion channel, Channelrhodopsin2, alters energy requirements for optogenetic control of the heart: Implications for in vivo transgene delivery, Gordon Research Conference, Ventura CA, February 2013.

  78. Boyle PM, Williams JC, Entcheva E, and Trayanova NA, Computational multiscale framework for cardiac optogenetics. Gordon Research Conference, Ventura CA, February 2013.

  79. Boyle PM, Williams JC, Entcheva E and Trayanova N, Spatial distribution of channelrhodopsin-2 affects optical stimulation efficiency in cardiac tissue, Heart Rhythm Society Meeting, Boston, MA, May 2012.

  80. Williams JC, Chen X, Xu J, and Entcheva E. Cardiac cell sensitivity to optogenetic stimulation: A computer modeling study. Biomedical Engineering Society Meeting, Boston, MA, 2011.

  81. Jia Z, Valiunas V, Lu Z, Bien H, Liu H, Rosati B, Brink PR, Cohen IS, and Entcheva E, Cardiac Optogenetics: Validation of a Cell Delivery System for Control of Cardiac Function by Light. Heart Rhythm Society Meeting, San Francisco, CA, 2011.

  82. Jia Z, Lu Z, Bien H, Liu H, Rosati B, Cohen IS, and Entcheva E, Optically-activated light-sensitive ion channels can pace cardiac tissue and generate propagating cardiac impulses. American Heart Association Scientific Sessions, Chicago, IL, Circ Res, 107(12):Suppl, S6, A23707, 2010.

  83. Jia Z, Bien H, and Entcheva E, Nontrivial effects of intercellular coupling on spatiotemporal intracellular Ca2+ dynamics in cardiac myocytes. American Heart Association Scientific Sessions, Chicago, IL, Circulation, 122(21):Suppl, A21246, 2010.

  84. Jia Z, Gordon C, Bien H, Brink PR and Entcheva E, Anti-arrhythmic effects of 4-phenylbutyrate (4PB) in cardiac myocytes. American Heart Association Scientific Sessions, Miami, FL, Circulation, 120:Suppl, S653-S654, 2009.

  85. Guenther J, Shah U, Jia Z, and Entcheva E, Synergistic gene and drug therapy to counteract arrhythmias, BMES Annual Conference, Pittsburgh, PA, October 2009.

  86. Leigh S, Tattu A, Zaman S, Budassi M, Jia Z, Bien H, and Entcheva E, M3: Maskless microscope-based micropatterning, BMES Annual Conference, Pittsburgh, PA, 2009.

  87. Leigh S, Jia Z, Bien H, and Entcheva E, Assembling and imaging long cables of live cardiomyocytes for validation of cable theory relationships, Annual Biophysical Society Meeting, Boston, MA, 2009.

  88. Protas L, Lu J, Bucchi A, Dun W, Kumari S, Jia Z, Lu, Z, Chen M, Brink PR, Cohen IS, Rosen MR, Entcheva E and Robinson RB, Overexpression of the skeletal muscle Na channel, SkM1, sustains normal conduction and is potentially antiarrhythmic in a depolarized myocardial syncytium simulating myocardial ischemia, Heart Rhythm Society Annual Meeting, San Francisco, CA, May 2008.

  89. Wang W, Gao J, Entcheva E, Cohen IS and Mathias RT, Transmural gradients in rate dependence of calcium handling and contractile properties in canine left ventricle, Biophysical Society Meeting, Long Beach, CA, February 2008.

  90. Entcheva E, Jia Z and Bien H, Asynchrony in spatiotemporal calcium dynamics and cardiac arrhythmias, APCTP Workshop on Self-Organization in Biological Systems, Pusan, South Korea, November 2007.

  91. Entcheva E, Jia Z and Bien H, Spatially discordant alternans in paced cardiac tissue, Gordon Research Conference on Cardiac Arrhythmias, Ventura, CA, March 2007.

  92. Jia Z, Bien H and Entcheva E, Spatially discordant alternans in quasi-1D cardiac tissue constructs, Dynamics Days, Boston, MA, January 2007.

  93. Wang W, Gao J, Bien H, Entcheva E, Cohen IS and Mathias RT, Transmural gradient in Na/K pump activity leads to regional differences in calcium handling, Biophysical Society Meeting, Baltimore, MD, March 2007.

  94. Shah U, Chung CY, Bien H and Entcheva E, Microtopographical effects of natural scaffolding on cardiac function, Annual BMES Meeting, Chicago, IL, October 2006.

  95. Bien H, Parikh P and Entcheva E, Optics?limitations on spatial resolution in fluorescence optical mapping, Frontiers in Live Cell Imaging Meeting, Washington, DC, April 2006.

  96. Bien H and Entcheva E, Co-existence of reentrant waves with spatially discordant alternans, Annual Heart Rhythm Society Meeting, Boston, MA, May 2006.

  97. Bien H, Varghese L, and Entcheva E. Optical mapping reveals direct cardiac arrhythmogenicity by inflammatory cytokines. Annual BMES Meeting, Baltimore, MD, October 2005.

  98. Bien H, Shah U, Chung CY, and Entcheva E. Uncovering temperature dependencies of excitability and connectivity in cardiomyocyte networks. Annual BMES Meeting, Baltimore, MD, October 2005.

  99. Chung CY, Bien H, and Entcheva E. Anisotropy and propagation patterns influence voltage and calcium in assembled cardiac cell networks. Annual BMES Meeting, Baltimore, MD, October 2005.

  100. Varghese L, Bien H, and Entcheva E. Multiparameter analysis of cardiac response to TNF-α and adrenergic stimulation. Annual BMES Meeting, Baltimore, MD, October 2005.

  101. Valiunas V, Parris M, Valiuniene L, Entcheva E, Cohen IS, Robinson RB, Rosen MR, Brink PR. Cell-cell coupling is critical to enable spread of pacemaker current between stem cells and cardiac myocytes. Gap Junction Symposium 2005.

  102. Entcheva E and Bien H. Imaging calcium dynamics and reentrant arrhythmias in cardiac cell networks. Gordon Research Conference (GRC) on Cardiac Arrhythmias, Santa Ynez Valley, CA, February 2005

  103. Gao J, Wang W, Bien H, Entcheva E, Cohen IS and Mathias RT. A contraction gradient across the ventricular wall is determined by the transmural gradient in Na/K pump current. Biophysical Society Meeting, Long Beach, CA, February 2005.

  104. Kostov Y, Rao G, Bien H, Farrell M, Yu H-J and Entcheva E. Minituarized fluorescence lifetime system for oxygen measurements in cardiac cell constructs. Annual BMES Meeting, Philadelphia PA, October 2004.

  105. Entcheva E., Complexity and Turbulence in Electrical Activity Imaged in Cardiomyocyte Networks, International Workshop on "Oscillations and Waves in Cells and Cell Networks", Cargese, France, May 2004.

  106. Chung CY, Zong X, Bien H, Yin L, Fang DF, Chu B, Hsiao BS and Entcheva E. Functional cardiac tissue grown on electrospun non-woven scaffolds. Annual BMES Meeting, Nashville TN, October 2003.

  107. Bien H, Farrell M, Yu H-J, Kostov Y and Entcheva E. Lifetime fluorescence measurements of oxygen uptake in cardiac cell networks using oxygen-sensitive scaffolds. Annual BMES Meeting, Nashville TN, October 2003.

  108. Entcheva E, Kostov Y, Bien H, Yin L, Chung CY, Dasari V and Farrell M. Versatile cellulose-based scaffolding for growing functional cardiac cell networks. Annual BMES Meeting, Nashville TN, October 2003.

  109. Entcheva E, Bien H and Tchernev E. Acoustic micromachining for three-dimensional anisotropy control in engineered cardiac tissue. Annual BMES Meeting, Nashville TN, October 2003.

  110. Entcheva E and Bien H, Analysis of propagation patterns in engineered cardiac tissue, Gordon Research Conference on Cardiac Arrhythmia Mechanisms, New London, NH, August 2003.

  111. Bien H, Dasari V, Farrell M, Yu H-J, Yin L, Chun C-Y and Entcheva E. Mechanical and spatial determinants of cytoskeletal geodesic dome formation in cardiac fibroblasts. ASM Conference on Bio-, Micro- and Nanosystems, New York, NY, July 2003.

  112. Entcheva E, Bien H and Tchernev E. Accoustic micromachining for controlled cell growth. Fourth Annual BioMEMs and Biomedical NanoTECH World 2003.

  113. Entcheva E, Bien H and Yin L. Electromechanical Performance of Engineered Cardiac Constructs. ET 2003: Engineering Tissues, 7th Hilton Head Workshop & Annual ET Workshop, March 2003.

  114. Entcheva E, Bien H and Yin L. [Ca2+]i changes in cardiac tissue constructs on 3D elastic matrices. Annual Meeting of the North-American Society for Pacing and Electrophysiology (NASPE), May 2003.

  115. Levine J, Setton T, Levine J, Guan E, Collazo L, Ge S, Entcheva E, Rafailovich M, The role of substrate mechanical properties in cardiac resynchronization, Annual Meeting of the American Physical Society (APS), Austin TX, March 2003.

  116. Setton T, Levine J, Levine J, Guan E, Collazo L, Ge S, Entcheva E, Rafailovich M, Correlation of cell and substrate mechanical properties, Annual Meeting of the American Physical Society (APS), Austin TX, March 2003.

  117. Entcheva E and Bien H. Tension development and nuclear eccentricity in topographically controlled cardiac syncytium. Third Annual BioMEMs and Biomedical NanoTECH World 2002, Columbus OH, 2002.