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Representative Papers 2001-2008

    • Zernicke, R.F., Wohl, G.R., Boyd, S.K., Judex, S. (2001) Functional adaptation of bone. Journal of Medical and Biological Engineering 21(2), 75-78.
    • Rubin, C.T, Sommerfeldt, D.W., Judex, S., Qin, Y.X. (2001) Inhibition of osteopenia by low magnitude, high frequency mechanical stimuli. Drug Discovery Today 6(16), 848-858.
    • Rubin, C.T., Xu, G., Judex, S. (2001) The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low magnitude mechanical stimuli. The FASEB Journal 15, 2225-2229.
    • Judex, S., Donahue, L.R., Rubin, C.T. (2002) Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. The FASEB Journal 16(10), 1280-1282. Reference for full-length article:  The FASEB Journal 10.1096/fj.01_0913fje (http:/www.fasebj.org/cgi/doi/10.1096/fj.01-0913fje).
    • Rubin, C.T., Judex, S., Hadjiargyrou, M. (2002) Skeletal adaptation to mechanical stimuli in the absence of formation or resorption of bone. The Journal of Musculoskeletal and Neuronal Interactions 2(3), 264-267.
    • Judex, S., Boyd, S.K., Qin, Y.X., Turner, S., Ye, K., Müller, R., Rubin, C.T. (2003) Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load. Annals of Biomedical Engineering 31(1), 12-20.
    • Judex, S., Boyd, S., Qin, Y-X, Miller, L., Müller, R., Rubin, C. (2003) Combining high-resolution microct with material composition to define the quality of bone tissue. Current Osteoporosis Reports 1(1). 11-19.
    • Judex, S., Garman, R.A., Squire, M.E., Donahue, L.R., Rubin, C.T. (2004) Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology. Journal of Bone and Mineral Research 19(4), 600-606.
    • Judex, S., Garman, R.A., Squire, M.E., Busa, B., Donahue, L.R., Rubin, C.T. (2004) Genetically linked site-specificity of disuse osteoporosis. Journal of Bone and Mineral Research 19(4), 607-613.
    • Squire, M., Donahue, L.R., Rubin, C.T., Judex, S. (2004) Genetic variations that regulate bone morphology in the male skeleton do not influence its susceptibility to mechanical unloading. Bone 35(6), 1353-1360.
    • Judex, S., Zhong, N., Squire, M., Ye, K., Donahue, L.R., Hadjiargyrou, M., Rubin, C.T. (2005) Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue. Journal of Cellular Biochemistry 94(5), 982-94.
    • Zhong, N., Garman, R., Squire, M., Donahue, L.R., Rubin, C.T., Hadjiargyrou, M., Judex, S. (2005) Gene expression patterns in bone after 4 d of hind-limb unloading in two inbred strains of mice. Aviation, Space, and Environmental Medicine 76, 530-535.
    • Murfee, W.L., Hammett, L.A., Evans, C., Xie, L., Squire, M., Rubin, C., Judex, S., Skalak, T.C. (2005) High-frequency low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle. Journal of Applied Physiology 98, 2376 - 2380.
    • Busa, B., Miller, L.M., Rubin, C.T., Qin, Y.X., Judex, S. (2005) Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcified Tissue International 77, 386-394.
    • Rubin, C.T., Judex, S., Qin, Y.X. (2006) Low-level mechanical signals and their potential as a non-pharmacologic intervention for osteoporosis. Age and Ageing 35 (S2), ii32-ii36.
    • Xie, L.Q., Jacobson, J., Choi, E., Busa, B., Donahue, L.R, Rubin, C.T., Miller, L.M., Judex, S. (2006). Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton. Bone 39(5), 1059-1066.
    • Gilsanz, V., Wren, T.A., Sanchez, M., Dorey, S., Judex, S., Rubin, C.T (2006) Low level, high frequency mechanical signals enhance musculoskeletal development of young women with low bone density. Journal of Bone and Mineral Research 21(9), 1464-1474.
    • Judex, S., Lei, X., Han, D., Rubin, C. (2007) Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. Journal of Biomechanics 40, 1333–1339.
    • Garman, R.A., Gaudette, G., Donahue, L.R, Rubin, C.T., Judex, S. (2007) Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation. Journal of Orthopaedic Research 25(6), 732-740.
    • Bastie, C., Zong, H., Xu, J., Busa, B., Judex, S., Kurland, I.J., Pessin, J.E. (2007) The Src family member fyn suppresses peripheral tissue fatty acid oxidation through tonic inhibition of AMP kinase signaling. Cell Metabolism 5(5), 371-81.
    • Miller, L.M, Little, W.B., Schirmer, A., Busa, B., Judex, S. (2007) Accretion of bone quantity and quality in the developing mouse skeleton. Journal of Bone and Mineral Research 22(7), 1037-45.
    • Garman, R., Rubin, C., Judex, S. (2007) Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphology. PLoS ONE 2(7), e653. doi:10.1371/journal.pone.0000653.
    • Ozcivici, E., Garman, R., Judex, S. (2007) High-frequency oscillatory motions enhance the simulated mechanical properties of non-weight bearing trabecular bone. Journal of Biomechanics 40(15), 3404-3011.
    • Carlson, K.J., Judex. S. (2007) Increased non-linear locomotion alters diaphyseal bone shape. The Journal of Experimental Biology 210, 3117-3125.
    • Lublinsky, S., Ozcivici, E., Judex. S. (2007) An automated algorithm to detect the trabecular-cortical bone interface in microCT images. Calcified Tissue International 81(4), 285-293.
    • Rubin, C.T., Capilla, E., Luu, Y.K., Busa, B., Crawford, H., Nolan, D.J., Mittal, V., Rosen, C., Pessin, J.E., Judex, S. (2007) Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proceedings of the National Academy of Sciences 104(45), 17879–17884.
    • Chen, X., Nasiri, A., Judex, S., Broadus, A.E. (2007) Mechanical regulation of PTHrP expression in entheses. Bone 41(5), 752-759.
    • Hishmeh, S., Judex, S., Cardoz, H., Jaggi, S. (2007) Oral supplementation of chondroitin sulfate to facilitate fracture healing: a pilot study. Journal of Orthopaedics 4(4), e2 (http://www.jortho.org/2007/4/4/e2/index.htm).
    • Squire, M., Brazin, A., Keng, Y., Judex, S. (2008) The influence of baseline bone morphometry on the gender- and site-specific dependency of disuse osteopenia. Bone 42(2):341-349.
    • Xie, L., Rubin, C., Judex, S. (2008) Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations. Journal of Applied Physiology 104(4):1056-62.
    • Carlson, K.J., Lublinsky, S., Judex, S. (2008) Do different locomotor modes during growth modulate trabecular architecture in the murine hind limb? Integrative and Comparative Biology 48: 385-393.

    • Carlson, K.J., Lublinsky, S., Judex, S. (2008) Do different locomotor modes during growth modulate trabecular architecture in the murine hind limb? Integrative and Comparative Biology 48, 385-393.

    • Ozcivici, E., Ferreri, S., Qin, Y.X., Judex, S. (2008) Determination of bone's mechanical matrix properties by nanoindentation. Methods in Molecular Biology (Osteoporosis: Methods and Protocols) 455, 323-34.

    • Luu, Y.K., Lublinsky, S., Ozcivici, E., Capilla, E., Pessin, J.E., Rubin, C.T., Judex, S. (2009) In vivo quantification of subcutaneous and visceral adiposity by micro computed tomography in a small animal model. Medical Engineering & Physics 31(1), 34–41.

    • Luu, Y, Capilla, E., Rosen, C, Gilsanz, V., Pessin, J., Judex, S., Rubin, C.T. (2009) Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary induced obesity. Journal of Bone and Mineral Research 24(1), 50-61.

    • Hwang, S.J., Lublinsky, S., Seo, Y.K., Kim, I.S., Judex, S. (2009) Extremely small-magnitude accelerations enhance bone regeneration. Clinical Orthopaedics and Related Research 467(4), 1083-1091.

    • Judex, S., Gupta, S., Rubin, C.T. (2009) Regulation of mechanical signals in bone. Orthodontics and Craniofacial Research 12, 94–104.

    • Lublinsky, S., Luu, Y.K., Rubin, C., Judex, S. (2009) An automated algorithm to separate visceral from subcutaneous fat in micro computed tomographies.  Journal of Digital Imaging 22(3), 222-231.

    • Luu, Y.K., Pessin, J.E., Judex, S., Rubin, J., Rubin, C.T. (2009) Mechanical signals as a non-invasive means to influence mesenchymal stem cell fate, promoting bone and suppressing the fat phenotype. IBMS BoneKEy 6(4): 132-149.

    • Holguin, N., Muir, J., Rubin, C., Judex, S. (2009) Short applications of high-frequency mechanical signals attenuate swelling of the intervertebral disc during bed rest. The Spine Journal 9(6), 470-477.

    • Bandstra, E.R., Thompson, R.W., Nelson, G.A., Willey, J.S., Judex, S., Cairns, M.A., Benton, E.R., Vazquez, M.E., Carson, J.A., Bateman, T.A. (2009). Musculoskeletal changes in mice from 20–50 cGy of simulated galactic cosmic rays. Radiation Research 172(1), 21-29.

    • Judex, S., Carlson, K.J. (2009) Is bone’s response to mechanical signals dominated by gravitational loading? Medicine & Science in Sports & Exercise 41(11), 2037-2043.

    • Lee, B.J., Cox, G., Maddatu, T., Judex, S., Rubin, C.T. (2009) Devastation of bone tissue in the appendicular skeleton parallels the progression of neuromuscular disease. Journal of Musculoskeletal and Neuronal Interactions 9(4), 215-224.

    • Judex, S., Luu, Y.K., Ozcivici, E., Adler, B., Lublinsky, S., Rubin, C.T. (2010) Quantification of adiposity in small rodents using micro-CT. Methods 50(1), 14-19.

    • Ozcivici, E., Luu, Y.K., Adler, B., Qin, Y.X., Rubin, J., Judex, S., Rubin, C.T. (2010) Mechanical signals as anabolic agents in bone. Nature Reviews Rheumatology 6(1), 50-59.

    • Judex, S., Rubin, C.T. (in press) Is bone formation induced by high-frequency mechanical signals modulated by muscle activity? Journal of Musculoskeletal and Neuronal Interactions.

    • Grine, F.E., Judex, S., Daegling, D.J., Ozcivici, E., Ungar, P.S., Teaford, M.F., Sponheimer, M., Scott, J., Scott, R.S., Walker, A. (in press) Modeling craniofacial biomechanics, and functional and dietary inferences in hominin paleontology. Journal of Human Evolution.

    • Wallace, I.J., Middleton, K.M., Lublinsky, S., Kelly, S.A., Judex, S., Garland, T., Demes, B. (in press) Functional significance of genetic variation in limb bone diaphyseal structure. American Journal of Physical Anthropology.

    •  Luu, Y.K., Ozcivici, E., Capilla, E., Adler, B., Chan, E., Shroyer, K., Rubin, J., Judex, S., Pessin, J.E., Rubin, C.T. (in press) Development of diet induced fatty liver disease in the aging mouse is suppressed by brief daily exposure to low magnitude mechanical signals.  International Journal of Obesity.

Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794-2580