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Yi-Xian Qin, Ph.D.
 
 
Post-Doctoral
Fellows
 
 
Doctoral Students
 
 
Current Undergraduate Students
 
 
Post Doctoral and
Doctoral Alumni
 
 
Masters Students
 
 
Medical Fellows
 
 
Former Undergraduate
Students
 
 
Former High School
Students
 
 
 

Post-Doctoral Fellows
Minyi Hu, Ph.D.    (2008-Present)

Minyi Hu, Ph.D. Dr. Minyi Hu holds a Ph.D. degree in Physiology and Biophysics and a Master degree in Basic Health Sciences from Stony Brook University. She has extensive experiences in research areas of bone biomechanics and cellular response to mechanical signals. The goal of her Ph.D. thesis research was to develop a novel, non-invasive mechanical stimulus to inhibit bone loss under disuse condition. Upon completion of her Ph.D. study, Dr. Hu was promoted to the position of Postdoctoral Research Associate. Her current research focus is to study calcium response of bone cells to in vitro and ex vivo biomechanical stimulations. Based on her research efforts, Dr. Hu has been honored with awards including Young Investigator Travel Grant (ASBMR 2012), Student Short Talk Travel Award (BMES-SPRBM 2012), President's Poster Competition Award (ASBMR 2011), Webster Jee Young Investigator Award (ICHTS 2011), and Student Paper Award (International Bone Fluid Flow Workshop 2010).

Minyi Hu's LinkedIn

Hua Yue, M.D./Ph.D.    (2013-Present)

Hua Yue, M.D./Ph.D. Hua Yue, M.D./Ph.D., is an Associate Chief Physician in the Department of Osteoporosis, Metabolic Bone Disease and Genetic Research Unit, Shanghai Jiao Tong University affiliated Shanghai People’s Hospital. At present, She is a visiting scholar working in the Department of Biomedical Engineering, Stony Brook University. Her research interests are molecular genetic mechanisms of osteoporosis and metabolic bone disease. In the past few years, Dr. Yue and Her colleagues have established the Chinese Han ethnic peak bone mineral density nuclear families and carried out multiple candidate genes SNP studies in osteoporosis. Meanwhile, a lot of gene mutation detection work has been done in the area of monogenic metabolic bone diseases and reported some new gene mutations in the world. Altogether, 6 papers have been published in journals of bone metabolism, including Osteoporosis International, Journal of Bone and Mineral Metabolism, and Bone, et al. Currently, Dr. Yue is holding a “National Natural Science Foundation” grant and “Shanghai Rising-Star Program”, granted by Shanghai Science and Technology Committee (STCSM). As one of the key investigators, She is also involved in several other National Natural Science Foundation grants.



Doctoral Students
Liangjun Lin, M.S.    (2008-Present)

Liangjun Lin, M.S. Liangjun Lin holds a M.S. degree of Biomedical Enginnering from Stony Brook University, and is currently a Ph.D. candidate. His research interests include biomechanics, quantitative ultrasound, and orthopaedics. Liangjun's current research is focused on 1) developing a novel quantitative ultrasound measurement protocol to predict the principal structural orientation of spherical trabecular bone model; 2) using finite element analysis to evaluate the mechanical properties in the principal structural orientation predicted by quantitative ultrasound; 3) applying this novel quantitative ultrasound measurement on human calcaneus as an improved evaluation for the mechanical properties. It is hypothesized that by applying the novel quantitative ultrasound measurement of principal structural orientation on human calcaneus, the correlation between the quantitative ultrasound parameters and the mechanical properties of calcaneus can be increased. Based on his excellent performance working on his thesis entitled "Analysis of Principal Structural Orientation of Trabecular Bone Using Quantitative Ultrasound", Liangjun has been honored with Best Poster Presentation Award (Department of Biomedical Engineering, Stony Brook University 2012) and President's Poster Competition Finalist (ASBMR 2012).

Liangjun Lin's LinkedIn

Tony Zhang, M.S.    (2011-Present)

Tony Zhang, M.S. Tony Zhang's research interest has a wide spectrum ranging from the technology-assisted rehabilitation for individuals with neurological disorders, to the non-invasive diagnostic and therapeutic orthopedic mechanisms that can be utilized in the treatment and prevention of disease and injury of bone tissue. One of his research interests is rehabilitation science including motor control and FES-induced movement and exercise interventions. He did related musculoskeletal  researches during his senior year in undergraduate study and had one paper, Research on the Rehabilitation of Muscle Function of Stroke patients Based on EEG and EMG Signals, published on one of China‘s core biomedical journals. During Tony's continuous study in the BME Department of Cornell University, he chose biomedical instrumentation and Rehabilitation as his specialty and fulfilled the final design project of Pediatric Head Circumference sensing device design, aiming to promote the health condition of newborn babies and toddlers. Currently Tony is working in the Orthopedic Research Lab with Professor Yi-Xian Qin at Stony Brook University studying the new therapeutic approach for the anabolic treatment of immobilization-induced osteopenia. Disuse is a common clinical condition associated with long-term bed resting and disuse induces bone loss by increasing bone resorption and decreasing bone formation. Disuse also affects millions of patients with postmenopausal osteoporosis. Results of Scl-Ab on increasing bone mass through stimulating bone formation and inhibiting bone resorption has been observed in previous animal study conducted by Amgen. Sclerostin deficiency in humans and together with data from sclerostin-knockout mice suggested that sclerostin inhibition might be an attractive approach for the development of a novel bone anabolic agent.

Nan Shen, M.S.    (2012-Present)

Nan Shen, M.S. Nan Shen is a bioengineer interested in mechanosensitive genes in bones and cartilage. At present, she is working with a mechanosensitive microRNA - microRNA 365. MiR 365 was previously found to be proliferation-favoring and involved in oncogenesis. But now its role in promoting chondrogenesis is unveiled and Nan is investigating if it is able to restore bone growth in absence of mechanical stimulus. Hindlimb suspended transgenetic mice (8-10 folds of wild type miR365 expression) are compared with hindlimb suspended wild-types. Biomechanical, hitsomorphological, and biomolecular analysis are being done to present a whole map of miR365’s roles in bones, cartilage, connective tissues and sub-chondral red bone marrow.

Ram Ghosh, B.S.    (2013-Present)

Ram Ghosh, B.S. Ram Ghosh is currently a doctoral graduate student in the Department of Biomedical Engineering Orthopeadic Research Laboratory. He joined in this lab during his junior year as an undergraduate student at Stony Brook University. His research focuses on the development of non-invasive ultrasonic system for bone and tissue assessment. The main goal of his project is image reconstruction using scanning acoustic diagnostic system. He is also involved in the project related to therapeutic ultrasound. This is a novel technique to ensure a faster fracture healing. Besides doing research, Ram also likes to do skateboarding.



Current Undergraduate Students
Neville Bethel, B.S./B.E.    (2013-Present)

Neville Bethel, B.S./B.E. Neville's research interests are the application of computational tools and experimental expertise to design and analyze macromolecular structures used in biological processes. His current project focuses on using Abaqus to test the strain amplification model of the osteocyte. By using nanoCT data of osteocyte cannuliculi, advanced data processing algorithms and current knowledge of the osteocyte cytoskeleton, Neville has recreated the entire osteocyte cytoskeleton for testing using the Finite Element Method (FEM). With this model, he seeks to answer the fundamental questions of how the osteocyte senses strain, and how this mechanism can fail in older osteocytes. Several awards that Neville has received include the Minority Access to Research Careers (MARC) Fellowship from September 2011 to May 2013 and the Summer Research Training Program (SRTP) Fellowship at UCSF from May 2012 to August 2012.


Post-Doctoral and Doctoral Alumni
Frederick Serra-Hsu, Ph.D.    (2004-2013)

Frederick Serra-Hsu, Ph.D. Thesis Topic: "Non-invasive Ultrasound Prediction for Bone Strain."

Jiqi Cheng, Ph. D.    (2006-2012)

Jiqi Cheng, Ph.D.
Orthopaedic Biomechanics and Bioinstrumentation. Research Focus: Understanding the effects of bone fluid flow on osteoblastic cell growth using microfluidics.

Sardar Uddin, Ph.D.    (2008-2012)

Sardar Uddin, Ph.D. Thesis Topic: Ultrasound stimulations of bone cells and reactions pathways in vitro and in vivo.

Wei Lin, Ph. D.     (1997-2004)

Wei Lin, Ph.D.
Doctorate Graduation in May, 2001. Dissertation title: "Scanning Acoustic Mapping as a Means of Estimation of Bone Properties."
Orthopaedic Biomechanics and Bioinstrumentation Post-Doctoral Fellow. Research Focus: Development of Ultrasound Imaging System for Bone Quality Assessment. Current: Assistant Professor of BME, Stony Brook University.

Eric Mittra, Ph. D.    (1998-2004)

Eric Mittra, Ph. D. graduation in August, 2000. Dissertation Title: Trabecular Bone Adaptation and its Mechanical Strength in Response to Low Magnitude, High Frequency Loading."

Anita Saldanha, Ph. D.    (1998-2005)

Anita Saldanha, Ph. D. graduation in May, 2005. Dissertation Title: "Intracortical Fluid Flow and Perfusion Patterns in Cortical Bone in Response to Intramedullary Pressure."

Yi Xia, Ph. D.    (2001-2006)

Yi Xia, Ph. D. graduation in May, 2006. Dissertation Title: "Non-invasive assessment of bone quality using scanning confocal ultrasound."

Yizhi Meng, Ph. D.    (Cornell University)

Yizhi Meng, Ph.D. 2005-Present
Orthopaedic Biomechanics and Bioinstrumentation. Research Focus: Understanding the effects of bone fluid flow on osteoblastic cell growth using microfluidics.

Suzanne Ferrari, Ph.D.    (2003-2009)

Suzanne Ferreri, Ph.D. Thesis Topic: "Prediction of Bone Quality using Micro Finite Element Analysis and High Resolution Structural Imaging."

Ho-Yan Lam, Ph.D.    (2002-2008)

Ho-Yan Lam, Ph.D. Thesis Topic: "Anabolic Bone Adaptation Induced by Dynamic Musculoskeletal Contraction."


Masters Students
Kevin Oon    (2010-Present)

Thesis Topic: Finite element simulations for spinal manipulations and lower back pain.

Jing Dong    (2010-Present)

Thesis Topic: Finite element simulations for spinal manipulations and lower back pain.

Denis Evangelista    (2008-Present)

Thesis Topic: Finite element simulations for spinal manipulations and lower back pain.

Jianping Zhang, M.S.    (2006-2008)

Thesis Topic: "Finite element simulation for multi-channel fluid flow."

Adiba Ali, M.S.    (2005-2007)

Thesis Topic: "Countermeasure for disuse osteopenia and muscle atrophy using pharmaceutical and physical treatment."

Tao Peng, M.S.    (2004-2006)

Thesis Topic: "Bone Density and Quality Assessment using Quantitative Ultrasound Imaging in the Human Hip Region."

Meng Zhang, M.S.    (2004-2006)

Thesis Topic: "Interrelationship among interstitial fluid flow, anisotropic structure, loading frequency and geometry."

Tamara Kaplan, M.S.    (1999-2004)

Thesis Topic: "Bone remodeling and fluid flow."


Medical Fellows
Michael Sileo, M.D.    (2005-2006)

Orthopaedic Resident, Department of Orthopaedics. Topic: Shoulder tendon biomechanics under loading.

Yury Slesarenko, M.D.    (2005-2006)

Orthopaedic Resident, Department of Orthopaedics. Topic: Biomechanical evaluation of digital pulley reconstruction.

Brian Tomkins, M.D.    (2005-2006)

Orthopaedic Resident, Department of Orthopaedics. Topic: ACL repair evaluation.

Scott Levin, M.D.    (2005-2006)

Orthopaedic Resident, Department of Orthopaedics. Topic: Stability of wrist implants.

Kevin Nadel, M.D.    (2002-2004)

Orthopaedic Resident, Department of Orthopaedics.

Suk Namkoong, M.D.    (2002-2003)

Orthopaedic Resident, Department of Orthopaedics.


Former Undergraduate Students
David Chen    (2006-2007)

Undergraduate of Biomedical Engineering. Topic: Cross-sectional moment of inertia change for bone remodeling.

Lisa Lehman    (2006-2007)

Undergraduate of Biomedical Engineering. Topic: Bone adaptive potentials generated by dynamic muscle contraction using maximal moment of inertia.

Michael Y. Xiong    (2006-2007)

Undergraduate of Biomedical Engineering. Topic: Cell culture and differentiation under accelerated media.

Eduardo Vargas    (2005-2007)

Undergraduate of Biomedical Engineering, MARC Fellowship. Topic: Interrelationship between strain and non-invasive ultrasound measurement.

Jiong Chen    (2005-2007)

Undergraduate of Biomedical Engineering. Topic: Histomorphologic assessment of bone samples under fluid flow loading.

Emmanuel Kordiel    (2004-2006)

Undergraduate of Biomedical Engineering, Topic: Strain distribution in a mouse femur model.

Mohit Sharma    (2004-2006)

Undergraduate of Biomedical Engineering. Topic: ultrasonic assessment for bone materials.

Sailaja Akella    (2003-2005)

Undergraduate of Biomedical Engineering. Topic: Prediction of Bone Strength using FEA and Micro-CT with identified nanomechanical properties.

An Sung    (2002-2005)

Undergraduate of Biomedical Engineering. Topic: The evaluation of fluid flow in bone tissue.

Phillipe Amireault    (2000-2004)

Undergraduate of Biomedical Engineering. Topic: Nanomechanical property evaluation for bone.

Jason G. Lai    (1999-2003)

Undergraduate Honor class combined Medicine MD Program.

Yin Ding    (1999-2001)

Department of Electrical Engineering, Stony Brook, Senior design.

Albert Fenoy, B.S.    (1999-2000)

Senior research, School of Medicine, Stony Brook.

Matthew Gold    (1998-1999)

Undergraduate Material Sciences, Senior thesis.

Sabrina Khondak    (1998-1999)

Undergraduate, Department of Mechanical Engineering.

Sal Labruzzo    (1997-1999)

Undergraduate, Department of Biology.

Lytal Kaufman    (1997-1998)

Undergraduate, Department of Biomedical Engineering, University of Pennsylvania.

Jackie Gray    (1997-1998)

Undergraduate, Department of Biomedical Engineering, University of Pennsylvania.

Albert Ahn    (1990-2000)

Undergraduate-M.D. program, Brown University.


Former High School Students
Stephanie Wang    (2010)

Monte Vista High School, Cupertino, CA.

Aileen Jiang    (2010)

Montgomery High School, Somerset, NJ.

Julie Chang    (2010)

Herricks High School, New Hyde Park, NY

Evan Lazer    (2004-2006)

Northport High School, New York, 2006 Intel Semifinalists, Title "A Study of the Effectiveness of Quantitative Ultrasound for Assessing Bone Health."

Joyce Ng    (2001-2003)

Summer intern from New York Academy of Science intern program, project title: "A Study of Fluid Perfusion Patterns in Cortical Bone."

Rahal Kahanda    (2001-2002)

Ward Melville HS, Intel semifinalists (2002) "Promotion of Bony Ingrowth by Frequency and Pressure Specific Fluid Flow Stimulation."

Dan Cohen    (1999-2000)

Ward Melville HS, InSTAR program. College: Princeton University.

Craig Berman    (1998-2002)

Ward Melville HS, InSTAR program, winner of LISEF'99 and Intel International Science and Engineering Affair'99, Intel Semi-finalists, 2001, Title: "Characterization of Ultrasound in Osteoporotic-like Bone Tissue and its Clinical Application as a non-invasive Diagnostic System." College: Yale University.

John Yoon    (1998-2001)

Ward Melville HS, InSTAR program, Semi-finalists, 2001, Title: "Cross-sectional Assessment of Fluid Perfusion in Simulated Osteoporotic Bone." College: Cooper Union

Reed Mauser    (1998-2001)

Ward Melville HS, InSTAR program, winner of LISEF'99 and Intel International Science and Engineering Affair'99. College: Yale University.

Brian Rosenfeld    (1998-2000)

Ward Melville HS, InSTAR program, College: MIT.








Orthopedic Bioengineering Research Laboratory
Department of Biomedical Engineering
State University of New York Stony Brook
Bioengineering Building, Rm 215
Stony Brook, NY 11794-5281
p: 631.632.4382    f: 631.632.8577    e: yi-xian.qin@sunysb.edu