Clinton T. Rubin
       SUNY Distinguished Professor and Chair
           Department of Biomedical Engineering
           Director, Center for Biotechnology

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Research Focus

The major research focus of our lab's work is targeted towards understanding the cellular mechanisms responsible for the growth, healing, and homeostasis of bone. More specifically, we are interested in how biophysical stimuli (e.g., mechanical, electrical, ultrasound) mediate these responses. The clinical significance of this work is applicable to the inhibition of osteopenia, the promotion of bony ingrowth into prostheses or skeletal defects, and the acceleration of fracture healing. These goals are approached via interdisciplinary studies at the biochemical, molecular, cellular, tissue, organ, computational (e.g., FEM) and clinical levels.  Our lab is also very interested in how mechanical signals bias the fate selection of mesenchymal and hematopoietic stem cells, as a means of treating obesity and diabetes through developmental, rather than metabolic pathways. 

Dr. Rubin’s research into non-invasive, non-pharmacological intervention to control osteoporosis was referenced in National Geographic’s January 2001 article about surviving space travel. His studies show that the application of extremely low level strains to animals and humans will increase bone formation, and thus may represent the much sought after “anabolic” stimulus in bone.

 

Dr. Rubin is also working in collaboration with Marodyne Medical to bring Low Intensity Vibration to the clinic for non-drug therapies for injury and disease.

Our work on mechanical biasing of stem cells away from fat and towards bone, has inspired cartoonist Nicole Hollander to capture the "translational essence" of the work. The two-panel carton strip titled "Sylvia" was published around the world, on May 5, 2008.

Cartoon Posted with permission of N. Hollander.

               

 

Education

  • Res. Fellow - Biomechanics, Brigham & Women's Hosp. Boston, MA, 1984-5
  • Res. Assoc. - Cell Biology, Tufts Univ., Boston, MA, 1983-4
  • Ph.D. - Anatomy, Univ. of Bristol, Bristol, U.K., 1983
  • B.A. - Physiology, Harvard Univ., Cambridge, MA, 1977

Academic Appointments

  • 2000- Chair, Department of Biomedical Engineering
  • 1997- Visiting Scientist, Brookhaven National Laboratory, Upton, NY
  • 1997- Director, Center for Advanced Technology in Medical Biotechnology, New York State office of Science, Technology and Academic Research
  • 1995- Director, Program in Biomedical Engineering, S.U.N.Y., Stony Brook.
  • 1992- Professor of Orthopaedics, Anatomy, Molecular Biophysics & Mechanical Eng. S.U.N.Y., Stony Brook.
  • 1987- Director, Musculo-Skeletal Research Laboratory, S.U.N.Y., Stony Brook.
  • 1987-92 Associate Professor of Orthopaedics, Anatomy, & Mechanical Engineering, S.U.N.Y., Stony Brook.
  • 1984-87 Assistant Professor of Anatomy & Cell Biol., Tufts Univ. School Med., Boston, Mass.

Honors

  • 2012 Outstanding Clinical Investigator Award, Biomedical Engineering Society and the Society for Physical Regulation in Biology and Medicine, Combined Meeting.

  • 2009 Founder, Marodyne Medical, Inc.
  • 2009 Chief Scientific Officer, Marodyne Medical, Inc
  • 2005 Distinguished Professor; highest academic rank in SUNY system, as conferred by SUNY Trustees
  • 2003 Elizabeth Winston Lanier Kappa Delta Award for Outstanding Research, Amer. Academy of Orthopaedic Surgeons
  • 2002 Fellow, American Institute of Medical and Biological Engineers
  • 2002 Calgary Award in Orthopaedic Biomechanics, IV World Cong. Biomechanics
  • 2001 Founder, Juvent, Inc.
  • 2001 NYSTAR Distinguished Professor, New York State Office of Technology and Academic Research
  • 2000 Giovanni Borelli Award, American Society of Biomechanics
  • 1998- Board of Directors, New York Biotechnology Association
  • 1997- The Whitaker Foundation, Fellowship Advisory Committee
  • 1996 Fuller Albright Award, American Society of Bone and Mineral Research
  • 1994 Founder, Exogen, Inc.
  • 1993 John Charnley Award, The Hip Society, Amer. Acad. Orthop. Surgeons
  • 1990 Kappa Delta Award for Outstanding Research, Bioelectric Repair and Growth Society.
  • 1989-1994 Committee on Space Biology & Medicine, Space Studies Board, National Research Council
  • 1987-1992 Presidential Young Investigator Award, National Science Foundation.
  • 1986 European Society of Biomechanics Award for Excellence in Research.
  • 1985 Kappa Delta Society Young Investigator Award, Amer. Acad. Orthop. Surgeons

Publications via Google Scholar

Publications

Patents

  • Method for inducing a current and voltage in living tissue for the prevention of bone loss. Patent #4,993,413
  • Mechanical loading protocol for the prevention of osteoporosis, acceleration of fracture healing, and the promotion of bony ingrowth. #5,103,808
  • Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue. #5,191,880
  • Apparatus for the induction of high frequency strains into the axial skeleton to promote growth and repair. #5,273,028
  • Non-Invasive method and means for in-vivo bone-growth stimulation. #5,376,065
  • Method and system for therapeutically treating bone fractures and osteoporosis. #5,997,490
  • Method and system for therapeutically treating bone fractures and osteoporosis. #6,022,349
  • Chondrogenic and osteogenic genes to be used in the treatment of metabolic bone disease. Pending
  • Frequency scanning ultrasound as a non-invasive means to determine the physical properties of bone. Pending
  • Improvement of postural stability using low level, high frequency mechanical oscillations. Pending