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Danny Bluestein

T: 631.444.2156
F: 631.444.6646
E:

Office:
HSC T19-050
Stony Brook, NY
11794-8181

Danny Bluestein

Research Focus

My primary research interests are in biofluids and cardiovascular pathologies. I am studying blood flow in the cardiovascular system, with a special interest in flow induced cardiovascular pathologies, and the design optimization of cardiovascular prostheses. I envision to bring recent advancements made in various fields, namely numerical modeling, non-invasive flow measurement techniques, and innovative blood measurement techniques, to better understand the mechanisms underlying cardiovascular pathologies such as stenoses, aneurysms, vulnerable plaques, thrombus formation, and pathological flow fields past prosthetic heart valves and various blood recirculating devices (ventricular assist devices, etc.) that may lead to cardioembolic strokes. Additionally, I am studying the effects of smoking and second hand smoke on cardiovascular disease risk.

Specifically I am conducting research in the following areas:

  • Computational Fluid Dynamics (CFD) and Fluid Structure Interaction (FSI) modeling.
  • Multiscale modeling on multicluster supercomputers.
  • Digital Particle Image Velocimetry (DPIV).
  • In vitro simulation of physiological flows.
  • Platelet assays for studying thromboembolism.
  • Flow cytometry.
  • Animal models (sheep) to study free emboli formation in heart valves using Transesophageal Echocardiography (TE) and Transcranial Doppler.

 

Numerical simulation of blood flow past a St. Jude Medical bileaflet mechanical heart valve prosthesis, implanted with a 15 degrees tilt in the aortic position (side view cross section). The simulation is unsteady (deceleration, after peak systole) and turbulent (Wilcox k-Omega model), and the fluid has whole blood viscoelastic properties. The tilted valve generates strong jets and a prominent wake of shed vortices, both conducive to platelet activation and aggregation. This may lead to the formation of free emboli (blood clots) which increase the risk of systemic cardioembolism.

Education

  • Ph.D. - Mechanical and Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 1992.
  • M.Sc. - Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel, 1985.
  • B.Sc. - Aeronautical Engineering, Technion, Israel Institute of Technology, Haifa, Israel, 1981.

Academic Appointments

  • 2008-Present Professor, Department of Biomedical Engineering, Stony Brook University.
  • 2002-2008 Associate Professor (with tenure), Department of Biomedical Engineering, Stony Brook University.
  • 1996-2002 Assistant Professor, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY.
  • 1993-1996 Visiting Assistant Professor, Department of Mechanical Engineering, Florida International University, Miami, FL. Manager of the Biofluids lab.
  • 1992-1993 Adjunct Assistant Professor, Biomedical Engineering Dept., University of Miami, Coral Gables, FL.
  • 1992 Research Associate, Biomedical Engineering Dept., Memphis State University, Memphis, TN.

Honors

  • 2010 - Man of the Year in Science, the Village Times Herald.
  • 2010 - Quantum award, NIBIB, National Institutes of Health.
  • 2010 - Elected Fellow, American Institute of Medical and Biological Engineering (AIMBE).
  • 2006 - Keynote Lecture, 5th World Congress of Biomechanics.
  • 2004 - Outstanding Service to the Department of Biomedical Engineering, Stony Brook.
  • 2003 - Established Investigator Award, American Heart Association
  • 2000 - Campus Life Award, Student Politi Association and the Department of Student Union and Activities, Stony Brook.
  • 1998 - Mentor Award, Summer Research Institute at Stony Brook
  • 1995 - International Who's Who in Medicine
  • 1993 - Outstanding International Scholar (Beta Theta Chapter of the University of Miami)

Professional Activities

Offices held in professional societies:

  • Chair (elected 2006-2009), Biofluids Committee, ASME, Bioengineering Division (BED)

Editorial Positions:

  • Associate Editor, ASME Journal of Medical Devices
  • Editorial Board, Expert Review of Medical Devices
  • Editorial Board, Heart International

Industrial Positions:

  • Science Advisory Board (SAB), Micromed Cardiovascular, Inc., Houston, TX
  • Science Advisory Board (SAB), Syncardia Systems, Inc., Tucson, AZ
  • Reviewer:

    • National Institutes of Health, BTSS study section
    • National Institutes of Health, BTSS-BRP study section
    • National Science Foundation, Dir. for Biology Sciences, Div. Environmental Biology.
    • NSF BES CAREER proposals Review Panel
    • National Academy of Sciences, Twining Program Research Grants.
    • Reviewer for Journal of Biomechanics, Journal of Biomechanical Engineering, Annals of Biomedical Engineering, Medical & Biological Engineering & Computing, ASAIO Journal, Artificial Organs, Expert Review in Medical Devices, J. Heart Valve Disease, Experiments in Fluids, Prentice-Hall Inc., New Jersey- Engineering Textbooks, ASME FED.

    Membership in Professional Societies and Committees:

    • Member, ASME, Bioengineering Division (BED)
    • Member, Biomedical Engineering Society (BMES)
    • - Member, American Heart Association
    • - Member, American Stroke Association
    • Member, International Hemodynamic Society

    Conferences- organizing, chairing:

    • Co-Chair, Organizing Committee, Computational Fluid Dynamics (CFD) in Medicine and Biology in conjunction with the Seventh International Biofluid Mechanics Symposium, Dead Sea, Israel, 2012.
    • International Scientific Committee, 5th World Congress of Biomechanics.
    • Organizing Committee, Summer Bioengineering Conference 2009, Lake Tahoe, CA.
    • Organizing Committee, Summer Bioengineering Conference, June 25-29, 2008, Marco Island, FL.
    • Organizing Committee, 2nd International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008, Caltech, Pasadena, California.
    • Organizing Committee, Summer Bioengineering Conference, Keystone, CO, June 20-24, 2007, chair, Fluid Mechanics in Arterial Disease session.
    • Conference Co-Chair, 33rd Annual Northeast Bioengineering Conference, Stony Brook University, New York, March 10-11, 2007,
    • Chair, Cardiovascular Mechanics I & II sessions.
      International Scientific Committee, 5th World Congress of Biomechanics, Munich, July 29-August 4, 2006.
    • Chair, "Thrombosis in devices and Cardiovascular Pathologies" session, 5th World Congress of Biomechanics, Munich, July 29-August 4, 2006.
    • Chair, Blood and Thrombosis session, Summer Bioengineering 2005 Conference, Vail, CO.
    • Chair, Cardiovascular Flow Assessment Session, and Flow Mechanics of Stenosis and Stents Session, IMECE ASME Conference, 17-19 Nov 2004, Anheim, CA.
    • Chair, Thrombosis Session, 2004 Biomedical Engineering Society (BMES) Annual Fall Meeting, Oct. 13-16, 2004, Philadelphia, PA.
      International Bio-Fluid Symposium and Workshop, Organizing Committee, Theme Leader, December 12-14, 2003, CalTech, Pasadena, California
    • Chair, Cardiovascular fluid dynamics in healthy and pathologic states sessions, Summer Bioengineering 2003 Conference, Key Byscane, FL.
    • Chair, Fluid Mechanics: Cardiovascular Devices, Panel member- Symposium on Biofluids Education, IMECE 2002, New Orleans, November17-22, 2002.
    • Chair, Heart Valve Mechanics session, IMECE 2001, November 11-16, 2001, NYC, NY.
    • Chair, Flow-Induced Pathologies in Large Vessels session, BMES Fall 2001 meeting, October 4-7, 2001, Duke University, NC.
    • Co-chair, Cardiac Valve Mechanics session, Summer Bioengineering Conference, Snowbird, Utah, June 27 - July 1, 2001.
    • Chair, Cardiovascular Mechanics IV session, The 2000 International Mechanical Engineering Congress & Exposition, November 5-10, 2000, Orlando, Florida.
    • Program Committee, Co-Chair, Cardiac Mechanics track, BMES 2000, Seattle, October 12-14, 2000.
    • Chair, Vascular Grafts Stents and Flow Dynamics session, BMES 2000, Seattle, October 12-14, 2000.
    • Chair, ‘Arterial Stenosis’ session, BMES 1998 Annual Meeting, Cleveland, Ohio, October 10-13, 1998.
    • Organizing Committee, ASME /AIChE/ ASCE 1997 Summer Bioengineering Conference.
    • Chair, 'Blood/Material Interaction' and 'Cardiovascular Engineering 4' sessions, ASME /AIChE/ ASCE Summer Bioengineering Conference, Sun River, Oregon, June 11-15, 1997.
    • Co-chair, 'Biofluid Mechanics of Prosthetic Heart Valves' session, ASME (IMECE) Winter Annual Meeting, Atlanta, GA, November 17-22, 1996.

    Publications

    Click here to search Danny Bluestein's PubMed listings

    Contribution to Books

    • Xenos M. and Bluestein D., “Biomechanical aspects of Abdominal Aortic Aneurysm (AAA): Fluid Structure Interaction (FSI) studies of AAA behavior”. In Biomechanics and Mechanobiology of Aneurysms, Ed. McLoughlin, T., "Studies in Mechanobiology, Tissue Engineering and Biomaterials" (Series Editor: Prof. Amit Gefen)Verlag, 2011.
    • Bluestein, D. Lieber, B. B., and Sadasivan, C. “Flow and Clot”, in Neurovascular Disease Series, Vol. 1: Thrombus and Stroke. Wakhloo, A.K., Lieber, B.B.., Mericle, R., Linfante, I. , Gounis, M. (eds.), Marcel & Dekker. 2008, pp. 15-38.
    • Einav, S. and Bluestein, D. “Dynamics of Blood Flow and Platelet Transport in Pathological Vessels”. In Cardiac Engineering: From Genes and Cells to Structure and Function, S. Sideman and R. Beyar (eds.), Ann. N.Y. Acad. Sci., 2004, Vol. 1015, 351-367.
    • Bluestein, D. and Einav, S. Techniques in the Analysis of Stability of Pulsatile Flow through Heart Valves, in Biomechanics Systems Techniques and Applications: Cardiovascular Techniques, Volume II, Leondes, C.T. (ed.), CRC Press LLC, Boca Raton, FL, 2001, pp. 4-1:4-39.

    Peer Reviewed Journal Papers

    • Feng, R., Xenos, M., Girdhar, G., Davenport, J., Deng, Y., Bluestein, D. (2011) Blood Flow Simulation in a Stenosis Model Using Discrete Particle Dynamics: A Comparison Between DPD and CFD. Submitted to J. Biomechanics and Modeling in Mechanobiology
    • Claiborne T.E., Girdhar G., Gallocher-Lowe S., Sheriff J., Kato Y.P., Pinchuk L., Schoephoerster R.T., Jesty J., Bluestein D. (2011) Thrombogenic Potential of Innovia Polymer Valves versus Carpentier-Edwards Perimount Magna Aortic Bioprosthetic Valves. ASAIO J., 57(1), pp. 26-31. doi: 10.1097/MAT.0b013e3181fcbd86.
    • Xenos, M. Alemu, Y., Zamfir, D., Einav, S., Ricotta, J.J., Labropoulos, N., Tassiopoulos, A., Bluestein, D. (2010) The Effect of Angulation in Abdominal Aortic Aneurysms: Parametric Study With FSI Simulations Medical & Biological Engineering & Computing, 48:1175–1190. DOI: 10.1007/s11517-010-0714-y.
    • Alemu, Y., Girdhar, G., Xenos, M., Sheriff, J., Jesty, J., Einav, S., Bluestein, D. (2010) Design Optimization of a Mechanical Heart Valve for Reducing Valve Thrombogenicity – a Case Study with ATS valve. ASAIO J, 56(5):389-396, DOI: 10.1097/MAT.0b013e3181e65bf9.
    • Xenos, M., Rambhia, S.H., Alemu, Y., Einav, S., Ricotta, J.J., Labropoulos, N., Tassiopoulos, A., Ricotta, J. J., Bluestein, D. (2010) Patient Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling, Annals of Biomedical Engineering, , Vol. 38, No. 11, pp. 3323–3337. DOI: 10.1007/s10439-010-0094-3.
    • Yamaguchi, T., Ishikawa T. Imai, Y., Matsuki, N., Xenos, M., Deng, Y., Bluestein, D. (2010) Particle Based Methods for Multiscale Modeling of Blood Flow in the Circulation and in Devices– Challenges and Future Directions. Annals of Biomedical Eng., Vol. 38, No. 3, pp. 1225–1235.
    • Xenos, M., Girdhar, G., Alemu, Y., Jesty, J., Slepian, M.J., Einav, S., Bluestein, D. (2010) Device Thrombogenicty Emulator (DTE) − Design optimization Methodology for Cardiovascular Devices: A Study in Two Bileaflet MHV Designs. J. Biomechanics,s, 43: 2400–2409, DOI: 10.1016/j.jbiomech.2010.04.020
    • Bluestein, D., Chandran, K.B. Manning, K.B. (2010) Towards Non-thrombogenic Performance of Blood Recirculating Devices. Annals of Biomedical Eng., Vol. 38, No. 3, pp. 1236–1256.
    • Sheriff, J., Bluestein, D., Girdhar, G., Jesty, J. (2010) Brief Exposure to High Shear Stress Sensitizes Platelets to Subsequent Low-Shear Conditions. Annals of Biomedical Engineering, Vol. 38, No. 4, pp. 1442-1450
    • Einav, S., Gharib, M., Bluestein, D. (2010) Fifth International Biofluid Mechanics Symposium: Position Papers and Key Challenges: Pasadena, March 28–30, 2008 Annals of Biomedical Engineering, Vol. 38, No. 3, pp. 1162–1163.
    • Morbiducci, U., Ponzini, R., Nobili, M., Massai, D., Monteviecchi, F.M., Bluestein, D., Redaelli, A. (2009) Blood damage safety of prosthetic heart valves. Shear induced platelet activation and local flow dynamics: a fluid–structure interaction approach. J. Biomechanics, 42 (12): 1952-1960.
    • Xenos, Rambhia, S., Alemu, Y., Einav, S., Ricotta, J., Labropoulos, N., Apostolos, T., Bluestein, D. (2009) Mimics Based Image Reconstruction Augments Diagnosis and Management of Vascular Pathologies: A Study of ruptured Abdominal Aortic Aneurysms. Mimics Innovation Awards 2009, http://uc.materialise.com/mimics/mia2009
    • Rissland, P., Alemu, Y., Einav, S., Ricotta, J., Bluestein, D. (2009) Abdominal Aortic Aneurysm Risk of Rupture- Patient Specific FSI simulations Using Anisotropic Model. J. Biomech. Eng., 131, 031001 (March 2009) (10 pages)
    • Bluestein, D., Dumont, K., De Beule, M., Ricotta, J., Impellizzeri, P., Verhegghe, B., Verdonck, P. (2009) The Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm on Risk of Rupture - a Patient Specific Modeling Approach. J. Computer Methods Biomech. Biomed. Eng., 12(1):73-81.
    • Claiborne, T. E., Bluestein, D., Schoephoerster, R.T. (2009) Development and evaluation of a novel artificial catheter deliverable prosthetic heart valve and method for in vitro testing, Intl. J. Artif. Organs, 32(5):262-71.
    • Ricotta, J.J., Pagan, J., Xenos, M., Alemu, Y., Einav, S., Bluestein, D. (2008) Cardiovascular disease management: the need for better diagnostics by personalized computer models. Medical & Biological Engineering & Computing, 46(11):1059-68.
    • Girdhar, G., Sulan, X., Bluestein, D., Jesty, J. (2008) Low-nicotine cigarettes substantially increase platelet activation in smokers. Nicotine and Tobacco Research, 10(12), pp. 1-8.
    • Girdhar, G., Xu, S., Jesty, J., Bluestein, D. (2008) In-vitro model of platelet-endothelial activation due to cigarette smoke under cardiovascular circulation conditions. Annals of Biomedical Eng., Vol. 36, No. 7, pp. 1142–1151.
    • Bluestein, D., Dumont, K., De Beule, M., Ricotta, J., Impellizzeri, P., Verhegghe, B., Verdonck, P. (2008) The Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm on Risk of Rupture - a Patient Specific Modeling Approach. J. Computer Methods Biomech. Biomed. Eng., First Published on: 24 July 2008, DOI: 10.1080/10255840802176396
    • Yared, A. and Bluestein, D. (2007) Flow induced platelet activation and damage accumulation in a mechanical heart valve – numerical studies. Artificial Organs, 31(9):677–688.
    • Dumont, K., Vierendeels, J., van Nooten, G., Verdonck, P., Bluestein, D. (2007) Comparison of the Hemodynamic and Thrombogenic Performance of Two Bileaflet Mechanical Heart Valves using a CFD/FSI model. J. Biomech. Eng., 129; 558-565.
    • Raz, S., Yared, A., Einav, S., Bluestein, D. (2007) Flow Induced Platelet Activation in Models of Arterial Stenosis. Annals of Biomedical Eng. Vol. 35, No. 4, pp. 493–504.
    • Dumont, K., De Beule, M., Ricotta, J., Impellizzeri, P., Verhegghe, B., Verdonck, P., Bluestein, D. (2007) The Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm on Risk of Rupture - a Patient Specific Modeling Approach. J. Computer Methods Biomech. Biomed. Eng., Accepted for publication.
    • Yin, W., Krukenkamp, I.B., Saltman, A.E., Gaudette, G., Suresh, K., Bernal, O., Jesty, J., Bluestein, D. (2006) The Thrombogenic Performance of a St. Jude Bileaflet MHV in a Sheep Model. ASAIO J. Vol. 52(1), 28-33.
    • Bluestein, D. (2006) Towards Optimization of the Thrombogenic Potential of Blood Recirculating Cardiovascular Devices Using Modeling Approaches. Expert Rev. Medical Devices, 3(3), 267-270.
    • Zhou, M. Ladeinde, F., Bluestein, D. (2006) The flow of a power-law fluid in the near-wake of a flat plate. Physics of Fluids, 18,088102-1-4.
    • Raz, S., Yared, A., Einav, S., Bluestein, D. (2006) Flow Induced Platelet Activation in Models of Arterial Stenosis. Annals of Biomedical eng. Under revision.
    • Dumont, K., Vierendeels, J., van Nooten, G., Verdonck, P., Bluestein, D. (2006) Comparison of ATS Open Pivot Valve and St Jude Regent Valve using a CFD model based on fluid-structure interaction. Submitted to J. Biomech. Eng.
    • Dumont, K., De Beule, M., Ricotta, J., Impellizzeri, P., Verhegghe, B., Verdonck, P., Bluestein, D. (2006) The Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm on Risk of Rupture - a Patient Specific Modeling Approach. Submitted to J. Computer Methods Biomech. Biomed. Eng.
    • Avrahami, I., Dumont K., Einav, S., Gharib, M., Ricotta J., Bluestein D. (2006) Influence of microcalcifications on Vulnerable Plaque Mechanics using FSI modeling. In Submission.
      Yin, W., Krukenkamp, I.B., Saltman, A.E., Gaudette, G., Suresh, K.,
    • Bernal, O., Jesty, J., Bluestein, D. (2006) The Thrombogenic Performance of a St. Jude Bileaflet MHV in a Sheep Model. ASAIO J. Vol. 52(1), 28-33.
    • Yin, W., Gallocher, S., Pinchuk, L., Schoephoerster, R.T., Jesty, J., Bluestein, D. (2005) Flow Induced Platelet Activation in a St. Jude MHV, a Trileaflet Polymeric Heart Valve and a St. Jude Tissue Valve. Artificial Organs. 29(10):826–831.
    • Bluestein, D., Moore. J.E. (2005) Biofluids Educational Issues: An Emerging Field Aims to Define Its Next Generation. Annals of Biomedical eng., Vol. 33, No. 12: 1674 – 1680.
    • Schulz-Heik, K., Ramachandran, J., Bluestein, D., and Jesty, J. (2005) The extent of platelet activation under shear depends on platelet count: differential expression of anionic phospholipid and factor Va. Pathophysiology of Haemostasis and Thrombosis, Vol. 34, No. 6, 255-262.
    • Dumont, K., Impellizeri, P., Ricotta, J., Alemu, Y., Bluestein, D. (2005) Assessment of fluid wall shear stress and vessel wall stress in an 'ideal' atherosclerotic plaque model. Comput Methods Biomech Biomed Engin. Supp 1: p. 91-2.
    • Yin, W., Yared., A., Jesty, J., Affeld, K., Bluestein, D. (2004) Flow Induced Platelet Activation in Bileaflet and Monoleaflet Mechanical Heart Valves in a Left Ventricular Assist Device. Annals of Biomedical eng., Vol.32, No. 8, 1058-1066.
    • Bluestein, D., Yin, W., Affeld, K., Jesty, J., (2004) Flow-Induced Platelet Activation in a Mechanical Heart Valve. J. Heart Valve Dis, Vol. 13, No. 3, 501-508.
    • Bluestein, D. (2004) Research Approaches for Studying Flow Induced Thromboembolic Complications in Blood Recirculating Devices. Expert Rev. Medical Devices, 1(1), 65-80.
      Rubenstein, D., Jesty; J., Bluestein; D (2004) The Effects of Mainstream and Sidestream Cigarette Smoke Extracts and Nicotine on Platelet Activation under Static and Dynamic Flow Conditions. Circulation 109:78-83.
    • Ramachandran, J., Rubenstein, D., Bluestein, D., Jesty, J. (2004) Activation of platelets exposed to shear stress in the presence of smoke extracts of low-nicotine and zero-nicotine cigarettes: the protective effect of nicotine. Nicotine & Tobacco Research, 6(5), 835–841.
    • Bluestein D, Li, Y, and Krukenkamp, IB. (2003) Erratum to Free Emboli Formation in the Wake of Bi-Leaflet Mechanical Heart Valves and the Effects of Implantation Techniques. J. Biomechanics, 36 1065-1066.
    • Jesty, J., Yin, W., Perrotta, P., Bluestein, D. (2003) Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time. Platelets, 14, 11–17.
    • Adam J. Singer, Erik S. Mittra, Danny Bluestein, Judd E. Hollander (2002) Simulated wound irrigation impact pressures. Journal of Trauma, Critical Care, and Emergency Medicine, 3(1) 9-16.
    • Bluestein, D. (2002) Drug Delivery - Engineering Principles for Drug Therapy. The Quarterly Review of Biology, Vol. 77, 492.
    • Bluestein D, Li, Y, and Krukenkamp, IB. (2002) Free Emboli Formationin the Wake of Bi-Leaflet Mechanical Heart Valves and the Effects of Implantation Techniques. J. Biomechanics, 35(12) 1533-1540.
    • Bluestein D., Rambod, E. and Gharib, M. (2000) Vortex shedding as a mechanism for free emboli formation in mechanical heart valves. J. Biomech. Engr., Vol. 122, pp. 125-134.
    • Bluestein, D. (2000) Stent-induced thromboembolism. Annals of Biomedical Engineering, Vol. 28:3. 346-348.
    • Jesty, J. and Bluestein, D. (1999) The Use of Acetylated Prothrombin as a Substrate in the Measurement of the Procoagulant Activity of Platelets: Elimination of the Feedback Activation of Platelets by Thrombin. Analyt. Biochem., Vol. 272, No. 1, pp. 64-70.
    • Bluestein, D., Gutierrez, C., Londono, M. and Schoephoerster, R.T. (1999) Vortex shedding in arterial stenosis and its relevance to mural platelet deposition. Annals of Biomedical Engineering, Vol. 27:6, pp. 763-773.
    • Bluestein, D., Niu, L., Schoephoerster, R.T. and Dewanjee, M.K. (1997) Fluid mechanics of flow through a stenosis: relationship to the development of mural thrombus. Annals of Biomedical Engineering, Vol. 25, No. 2, pp. 344-356.
    • Bluestein, D., Niu, L., Schoephoerster, R.T., and Dewanjee, M.K. (1996) Steady flow in an aneurysm model: Correlation between numerical simulation and blood platelet deposition. J. Biomech. Engr., Vol. 118, No.3, pp. 280-286.
    • Bluestein, D. and Einav, S. (1995) The Effect of Varying Degrees of Stenosis on the Characteristics of Turbulent Pulsatile Flow Through Heart Valves. J. Biomechanics, Vol. 28, No. 8, pp. 915-924.
    • Bluestein, D., Einav, S. and Hwang, N.H.C. (1994): A Squeeze Flow Phenomenon at the Closing of a Bileaflet Mechanical Heart Valve. J. Biomechanics, Vol. 27, No. 11, pp. 1369-1378.
    • Bluestein, D. and Einav, S. (1994): Transition to Turbulence in Pulsatile Flow Through Heart Valves- A Modified Stability Approach. J. Biomech. Eng., Vol. 116, No. 4, pp. 477-487.
    • Bluestein, D., Viscarra, H., Niu, L. and Schoephoerster, R.T. (1994) Fluid Mechanics of Arterial Stenosis and Aneurysm: Relationship to Blood Platelet Deposition on the Wall. CSCE Eng. Mech., vol. IV, pp. 115-120.
    • Bluestein, D. and Einav, S. (1994): A Modified Stability Diagram of Pulsatile Flow Through Heart Valves Based on Improved Spectral Estimates of LDA Data. ASME FED Laser Anemometry: Advances and Applications, Vol. 191, pp. 125-133.
    • Bluestein, D. and Einav, S. (1993): Spectral Estimation and Analysis of LDA Data in Pulsatile Flow Through Heart Valves. Experiments in Fluids, Vol. 15, pp. 341-353.
    • Bluestein, D., and Hwang, N.H.C. (1993) The Squeeze Flow Field of a Mechanical Heart Valve at Closure. Annals of Biomedical Engineering, 1993; 21(S1):23.
    • Bluestein D., Menon, S., Wu, Z.J., S., Haubold, A., Armitage, T.L. and Hwang, N.H.C. (1993): The Closing Behavior of a New Bileaflet Mechanical Heart Valve. ASAIO Journal, Vol. 39 (3), pp. 398-402.
    • Bluestein, D., Einav, S. and Hwang, N.H.C.(1992) Stability of Flow Through Heart Valves: A Comparison Between the Traditional Approach and a Novel Approach. ASME BED Advances in Bioengineering, Vol. 22, pp. 427-431.
    • Bluestein, D. and Einav, S.(1986): The Effect of a Plane Wall in the Discharge of a Swirling Jet, Laser Anem. Fluid Mech., Vol. 3, pp. 151-154.

    Patents

    • An assay of the activation state of platelets. International patent application disclosure date 7/14/00 (based on US provisional patent application No. 60/143,702).

    Funding Agencies

    • National Institutes of Health
    • American Heart Association, NY Affiliate
    • American Heart Association, National
    • Binational Science Foundation
    • SOM Stony Brook
    • The Whitaker Foundation
    • National Science Foundation
    • FAMRI