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Danny Bluestein

T: 631.444.2156
F: 631.444.7530

HSC T15-050
Stony Brook, NY

Danny Bluestein

Research Focus

My primary research interests are in biofluids and cardiovascular pathologies. I am studying blood flow in the cardiovascular system, with a special interest in flow induced cardiovascular pathologies, and the design optimization of cardiovascular prostheses. I envision to bring recent advancements made in various fields, namely numerical modeling, non-invasive flow measurement techniques, and innovative blood measurement techniques, to better understand the mechanisms underlying cardiovascular pathologies such as stenoses, aneurysms, vulnerable plaques, thrombus formation, and pathological flow fields past prosthetic heart valves and various blood recirculating devices (ventricular assist devices, etc.) that may lead to cardioembolic strokes. Additionally, I am studying the effects of smoking and second hand smoke on cardiovascular disease risk.

Specifically I am conducting research in the following areas:

  • Computational Fluid Dynamics (CFD) and Fluid Structure Interaction (FSI) modeling.
  • Multiscale modeling on multicluster supercomputers.
  • Digital Particle Image Velocimetry (DPIV).
  • In vitro simulation of physiological flows.
  • Platelet assays for studying thromboembolism.
  • Flow cytometry.
  • Animal models (sheep) to study free emboli formation in heart valves using Transesophageal Echocardiography (TE) and Transcranial Doppler.


Numerical simulation of blood flow past a St. Jude Medical bileaflet mechanical heart valve prosthesis, implanted with a 15 degrees tilt in the aortic position (side view cross section). The simulation is unsteady (deceleration, after peak systole) and turbulent (Wilcox k-Omega model), and the fluid has whole blood viscoelastic properties. The tilted valve generates strong jets and a prominent wake of shed vortices, both conducive to platelet activation and aggregation. This may lead to the formation of free emboli (blood clots) which increase the risk of systemic cardioembolism.


  • Ph.D.-          Mechanical and Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 1992.
  • M.Sc.-          Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel, 1985.
  • B.Sc.-          Aeronautical Engineering, Technion, Israel Institute of Technology, Haifa, Israel, 1981.

Academic Appointments

  • 2008-          Professor, Department of Biomedical Engineering, Stony Brook University.
  • 2002-2008   Associate Professor (with tenure), Department of Biomedical Engineering, Stony Brook University.
  • 1996-2002   Assistant Professor, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY.
  • 1993-1996   Visiting Assistant Professor, Department of Mechanical Engineering, Florida International University, Miami, FL. Manager of the Biofluids lab.
  • 1992-1993   Adjunct Assistant Professor, Biomedical Engineering Dept., University of Miami, Coral Gables, FL.


  • 2013 - Keynote Lecture, ASME 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB2013)
  • 2013 - Keynote Lecture, International Symposium on Cardiovascular Disease and Vulnerable Plaque Biomechanics, Nanjing, China
  • 2010 - Man of the Year in Science, the Village Times Herald
  • 2010 - Quantum award, NIBIB, National Institutes of Health
  • 2010 - Elected Fellow, American Institute of Medical and Biological Engineering (AIMBE)
  • 2009 - Mimics Innovation Award
  • 2006 - Keynote Lecture, 5th World Congress of Biomechanics
  • 2004 - Outstanding Service to the Department of Biomedical Engineering, Stony Brook
  • 2003 - Established Investigator Award, American Heart Association
  • 2000 - Campus Life Award, Student Politi Association and the Department of Student Union and Activities, Stony Brook
  • 1998 - Mentor Award, Summer Research Institute at Stony Brook
  • 1993 - Outstanding International Scholar (Phi Beta Delta Honor Society for International Scholars)

Professional Activities

Membership in Professional Societies and Committees:

  • Fellow, American Institute of Medical and Biological Engineering (AIMBE)
  • Member, Biomedical Engineering Society (BMES)
  • Member, ASME, Bioengineering Division (BED)
  • Member, International Hemodynamic Society
  • Member, American Heart Association
  • Member, American Stroke Association

Offices held in professional societies:

  • Chair (elected 2006-2009), Biofluids Technical Committee, ASME, Bioengineering Division (BED)

Editorial Positions:

  • Associate Editor, ASME Journal of Medical Devices (2008-2012)
  • Editorial Board, Expert Review of Medical Devices
  • Editorial Board, Heart International


  • National Institutes of Health, NHLBI Surgery and Bioengineering Study Section, BTSS
  • National Institutes of Health, NIBIB SEP Study Section
  • National Institutes of Health, NHLBI Bioengineering Research Partnership Study Section
  • National Science Foundation
  • National Academy of Sciences, Twining Program Research Grants

Conferences - Organizing, Chairing:

  • Organizing Committee, 8th International Bio-Fluid Symposium and Workshop, February 12-14, 2016, CalTech, Pasadena, California
  • Track Chair, "Cardiovascular Engineering", BMES 2014 Annual Fall Meeting, San Antonio, TX, 2014
  • Symposia Organizer, "Vulnerable Plaque" and "Hemodynamics and Thrombosis", World Congress of Biomechanics 2014, Boston, MA
  • Conference Co-Chair, Organizing Committee, 1st International Conference on Computational Fluid Dynamics (CFD) in Medicine and Biology in conjunction with the 7th International Biofluid Mechanics Symposium, March 25-30, 2012, Dead Sea, Israel
  • Chair, "Cardiovascular Stents and Devices", Cellular Engineering & Modeling sessions, BMES 2011 Annual Fall Meeting, Hartford, CT, 2011
  • Organizing Committee, Summer Bioengineering Conference, Farmington, PA, 2011
  • Organizing Committee, Summer Bioengineering Conference, Lake Tahoe, CA, 2009
  • Organizing Committee, Summer Bioengineering Conference, Marco Island, FL, 2008
  • Organizing Committee, Theme Leader, 5th International Bio-Fluid Mechanics Symposium and Workshop, Caltech, Pasadena, CA, 2008
  • International Scientific Committee, 5th World Congress of Biomechanics, Munich, 2006
  • Chair, "Thrombosis in Devices and Cardiovascular Pathologies" Sessions, 5th World Congress of Biomechanics, Munich, 2006
  • Chair, "Blood and Thrombosis" Session, Summer Bioengineering Conference, Vail, C), 2005
  • Chair, "Cardiovascular Flow Assessment" Session and "Flow Mechanics of Stenosis and Stents" Session, IMECE ASME Conference, Anheim, CA, 2004
  • Chair, "Thrombosis" Session, BMES Annual Fall Meeting, Philadelphia, PA, 2004
  • Organizing Committee, Theme Leader, International Bio-Fluid Symposium and Workshop, CalTech, Pasadena, CA, 2003
  • Chair, "Cardiovascular Fluid Dynamics in Healthy and Pathologic States" Sessions, ASME-BED Summer Bioengineering Conference, Key Byscane, FL, 2003
  • Chair, "Fluid Mechanics: Cardiovascular Devices", Panel member- Symposium on Biofluids Education, IMECE 2002, New Orleans, LA, 2002
  • Chair, "Heart Valve Mechanics" Session, IMECE 2001, NYC, NY, 2001
  • Chair, "Flow-Induced Pathologies in Large Vessels" Session, BMES Annal Fall Meeting, Duke University, NC, 2001
  • Co-chair, "Cardiac Valve Mechanics" Session, Summer Bioengineering Conference, Snowbird, UT, 2001
  • Chair, "Cardiovascular Mechanics IV" Session, The 2000 ASME IMECE, Orlando, FL, 2000
  • Program Committee, Co-Chair, "Cardiac Mechanics" Track, BMES Annal Fall Meeting, Seattle, WA, 2000
  • Chair, "Vascular Grafts Stents and Flow Dynamics" Session, BMES Annual Fall Meeting, Seattle, WA, 2000
  • Chair, "Arterial Stenosis" Session, BMES Annual Fall Meeting, Cleveland, OH, 1998

Industrial Advisory Boards:

  • Science Advisory Board (SAB), Micromed Cardiovascular, Inc., Houston, TX
  • Science Advisory Board (SAB), Syncardia Systems, Inc., Tucson, AZ


Click here to search Danny Bluestein's PubMed listings

Contribution to Books:

  • Xenos M. Karakitsos, D. and Bluestein D. "Improving diagnostics of cardiovascular pathologies using patient specific imaging and numerical simulations". Critical Care Ultrasound, Eds. Lumb and Karakitsos, Elsevier ed. NY, USA, 2013.
  • Xenos M. and Bluestein D., “Biomechanical aspects of Abdominal Aortic Aneurysm (AAA): Fluid Structure Interaction (FSI) studies of AAA behavior”. In Biomechanics and Mechanobiology of Aneurysms, Ed. McLoughlin, T., "Studies in Mechanobiology, Tissue Engineering and Biomaterials" (Series Editor: Prof. Amit Gefen) Verlag, 2011.
  • Bluestein, D. Lieber, B. B., and Sadasivan, C. “Flow and Clot”, in Neurovascular Disease Series, Vol. 1: Thrombus and Stroke. Wakhloo, A.K., Lieber, B.B.., Mericle, R., Linfante, I., Gounis, M. (eds.), Marcel & Dekker. 2008, pp. 15-38.
  • Einav, S. and Bluestein, D. “Dynamics of Blood Flow and Platelet Transport in Pathological Vessels”. In Cardiac Engineering: From Genes and Cells to Structure and Function, Sideman, S. and Beyar, R. (eds.), Ann. N.Y. Acad. Sci., 2004, Vol. 1015, 351-367.
  • Bluestein, D. and Einav, S. Techniques in the Analysis of Stability of Pulsatile Flow through Heart Valves, in Biomechanics Systems Techniques and Applications: Cardiovascular Techniques, Volume II, Leondes, C.T. (ed.), CRC Press LLC, Boca Raton, FL, 2001, pp. 4-1:4-39.

Selected Peer Reviewed Journal Papers:

  • Sheriff J., Claiborne T.E., Tran P., Kothadia R., George S., Kato Y., Pinchuk L., Slepian M.J., and Bluestein D. (2015) Physical Characterization and Platelet Interactions Under Shear Flows of a Novel Thermoset Polyisobutylene-Based Co-Polymer. ACS Applied Materials and Interfaces, Accepted for publication.
  • Piatti, F., Sturla, .F, Marom, G., Sheriff, J., Claiborne, T.E., Slepian, M.J., Redaelli, A, Bluestein, D. (2015) Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach. J Biomechanics, Accepted for publication.
  • Sheriff J., Tran P.L., Hutchinson M., DeCook T., Slepian M.J., Blestein, D., Jesty J. (2015) Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner. Artificial Organs. Accepted for publication.
  • Mega, M., Marom, G., Halevi, R., Hamdan, A., Bluestein, D., Haj-Ali, R. (2015) Imaging Analysis of Collagen Fiber Networks in Cusps of Porcine Aortic Valves: Effect of their Local Distribution and Alignment on Valve Functionality. Computer Methods in Biomechanics and Biomedical Engineering. Accepted for publication.
  • Leung, S-L., Lu, Y., Bluestein, D., Slepian, M.J. (2015) Dielectrophoresis-Mediated Electrodeformation as a Means of Determining Individual Platelet Stiffness. Annals of Biomedical Engineering. Accepted for Publication.
  • Zhang, P., Zhang, N., Deng, Y., Bluestein, D (2015) A Multiple Time Stepping Algorithm for Efficient Multiscale Modeling of Platelets Flowing in Blood Plasma, J. Computational Physics, Vol. 284, pp. 668-686.
  • Merkle, V., Martin, D., Hutchinson, M., Tran, P., Behrens, A., Hossainy, S., Bluestein, D., Wu, X., Slepian, M. (2015) Hemocompatibility of Polyvinyl Alcohol-Gelatin Core-Shell Electrospun Nanofibers: A Novel Scaffold for Modulating Platelet Deposition and Activation. Applied Materials & Interfaces, 7(15), 8302-8312.
  • Xenos, M. Karakitsos, D., Labropoulos, N., Tassiopoulos, A., Bilfinger, D., Bluestein, D. (2015) Comparative Study of Flow in Right-Sided and Left-Sided Aortas - Numerical Simulations in Patient Based Models. Computer Methods in Biomechanics and Biomedical Engineering, Comput. Methods Biomech. Biomed. Eng. 18(4): 414-25.
  • Pothapragada, S., Zhang, P.,Sheriff, J.,Livelli, M., Slepian, M.J., Deng, Y., and Bluestein, D. (2015) A Novel Model of Human Platelets for Simulating Pseudopodia Formation in Response to Stimuli, Intl. J. Numerical Methods in Biomed.l Eng. Vol. 31(3). DOI: 10.1002/cnm.2672.
  • Xenos, M., Labropoulos, N., Rambhia, S., Alemu, Y., Einav, S. Tassiopoulos, A., Sakalihasan, N., Bluestein, D. (2015) Progression of Abdominal Aortic Aneurysm Towards Rupture: Refining Clinical Risk Assessment Using a Fully Coupled Fluid–Structure Interaction Method. Annals of Biomedical Engineering. DOI: 10.1007/s10439-014-1224-0.
  • Bluestein, D. and Slepian, M.J. (2014) Sticking with Synthetic Tissue Sealants. New England J. Medicine, 370;16:1556-1559.
  • Marom, G., Chiu, W-C., Crosby, J.R., DeCook, K.J., Prabhakar, S., Horner, M., Slepian, M.J., Bluestein, D. (2014) "Numerical Model of Full-Cardiac Cycle Hemodynamics in a Total Artificial Heart and the Effect of Its Size on Platelet Activation." J. Cardiovasc. Transl. Res.7(9): 788-796. doi: 10.1007/s12265-014-9596-y.
  • Raptis A, Xenos M, Dimasc S, Giannoukasd A, Labropoulose N, Bluestein D, Matsagkasa M (2014) Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms. Computer Methods in Biomechanics and Biomedical Engineering, (ahead-of-print), 1-9. DOI: 10.1080/10255842.2014.989389.
  • Sheriff, J., Girdhar, G., Chiu, W-C., Jesty, J., Slepian, M.J., Bluestein, D. (2014) "Comparative efficacy of in vitro and in vivo metabolized aspirin in the DeBakey ventricular assist device." J. Thromb. Thrombolysis 37(4): 499-506.
  • Zhang, P., Gao, C., Zhang, N., Slepian, M.J., Deng, Y., Bluestein, D. (2014) "Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics." Cell. Mol. Bioeng. 7(4): 552-574.
  • Chiu, W., Girdhar, G., Xenos, M., Alemu, Y., Soares, J.S., Lynch, B., Einav, S.,Slepian, M., Bluestein, D. (2014) Thromboresistance Comparison of the HeartMate II Ventricular Assist Device (VAD) with the Device Thrombogenicity Emulation (DTE)-Optimized HeartAssist 5 VAD. J. Biomechanical Eng. Vol. 136 / 021014-1-9, DOI:10.1115/1.4026254.
  • Pelosi, A., Sheriff, J., Stevanella, M., Fiore, G.B., Bluestein, D., Redaelli, A. (2014) Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation. J. Biomech. Modeling in Mechanobiology, 13:349–361. DOI: 10.1007/s10237-012-0445.
  • Chiu, W., Slepian, M., Bluestein, D. (2014) Thrombus Formation Patterns in the HeartMate II VAD- Clinical Observations Can Be Predicted by Numerical Simulations. ASAIO J. 60(2):237-240, DOI:10.1097/MAT.0000000000000034.
  • Bluestein, B., Soares, J.S., Zhang, P., Gao, C., Zhang, N., Slepian, M.J., and Deng, Y. (2014) Multiscale Modeling of Flow Induced Thrombogenicity with Dissipative Particle Dynamics (DPD) and Molecular Dynamics (MD). ASME J. Medical Devices.7(4):024502-024502-2, DOI:10.1115/FMD2013-16176.
  • Soares, J., Sheriff, J., Bluestein, D. (2014) A novel mathematical model of activation and sensitization of platelets subjected to dynamic stress histories. J. Biomech. and Modeling in Mechanobiology, 12:1127–1141, 10.1007/s10237-013-0469-0.
  • N. Zhang, P. Zhang, W. Kang, D. Bluestein and Y. Deng (2014) Parameterizing the Morse potential for Coarse-Grained Modeling of Blood Plasma", J. Computational Physics, Vol. 257, Part A, Pages 726–736. DOI: 10.1016/j.jcp.2013.09.040.
  • Soares, J.S., Gao, C., Alemu, Y., Slepian, M., Bluestein, D. (2013) Simulation of platelets suspension flowing through a stenosis model using a dissipative particle dynamics approach. Annals of Biomedical Engineering. 41(11), pp 2318-2333, DOI: 10.1007/s10439-013-0829-z.
  • Sheriff, J., Girdhar, G., Chiu, W.C., Jesty, J., Slepian, M.J., Bluestein, D. (2014) “Reduction in Shear-Induced Platelet Activation in the MicroMed DeBakey Ventricular Assist Device Post-Aspirin Therapy: An In Vitro Study.” J. Thrombosis and Thrombolysis. 37:499–506, DOI 10.1007/s11239-013-0997-6.
  • Liang, X. Xenos, M., Alemu, Y., Rambhia, S.J., Lavi, I., Kornowski, R., Gruberg, L., Einav, S., Bluestein, D. (2013) Biomechanical factors in coronary vulnerable plaque risk of rupture: intravascular ultrasound-based patient-specific fluid-structure interaction studies. J Coronary Artery Disease, 24(2):75-87.
  • Claiborne, T.E., Sheriff, J.Kuetting, M., Steinseifer, U., Slepian, M.J., Bluestein, D. (2013) In Vitro Evaluation of a Novel Hemodynamically Optimized Trileaflet Polymeric Prosthetic Heart Valve. J. Biomechanical Eng. Special Issue "Biomechanical Engineering- Year in Review", 135(2):021019, 1-8.
  • Sheriff, J., Soares, J., Xenos, M., Jesty, J., Bluestein, D. (2013) Evaluation of Shear-Induced Platelet Activation Models Under Constant and Dynamic Shear Stress Loading Conditions Relevant to Devices. Annals of Biomedical Engineering, Vol. 41, No. 6, pp. 1279–1296, DOI: 10.1007/s10439-013-0758-x.
  • Bluestein, D.,Girdhar, G, Einav, S., Slepian, M.J. (2013) Device thrombogenicity emulation: a novel methodology for optimizing the thromboresistance of cardiovascular devices.J. Biomech., 46, 338–344, http://dx.doi.org/10.1016/j.jbiomech.2012.11.033.
  • Claiborne, T.E., Xenos, M., Sheriff, J., Chiu, W.C., Peter, D., Soares, J., Alemu, Y., Gupta, S., Judex, S., Slepian, M.J., Bluestein, D. (2013) Optimization of a Novel Trileaflet Polymeric Prosthetic Heart Valve using Device Thrombogenicity Emulation (DTE) Methodology. ASAIO J, 59(3):275-83, DOI: 10.1097/MAT.0b013e31828e4d80.
  • Slepian, M.J., Girdhar, G., Alemu, Y., Soares, J., Smith, R., Einav, S., Bluestein, D. (2013) The SynCardiaTM Total Artificial Heart: Review of In Vivo, In Vitro, and Computational Modeling Studies. J. Biomechanics, 46, 266–275. http://dx.doi.org/10.1016/j.jbiomech.2012.11.03.2
  • Elad, D. and Bluestein, D. (2013) Biofluid Mechanics: Innovations and Challenges (editorial). J. Biomechanics. 46 (2013) 207, http://dx.doi.org/10.1016/j.jbiomech.2012.11.034.
  • Girdhar, G., Xenos, M., Alemu, Y., Lynch, B., Jesty, J., Einav, S., Slepian, M.J., Bluestein, D. (2012) Device Thrombogenicity Emulation: A Novel Method for Optimizing Mechanical Circulatory Support Device Thromboresistance. PLoS One, March 2012, Vol. 7(3) e32463, doi:10.1371/journal.pone.0032463.
  • Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS; (2012) Platelet Colloquium Participants. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circulation: Cardiovascular Interventions, 5: 296-304, doi: 10.1161/CIRCINTERVENTIONS.111.965426.
  • Claiborne, T.E., Slepian, M.J., Bluestein, D. (2012) Polymeric Trileaflet Prosthetic Heart Valves: Evolution and Path to Clinical Reality. Expert Rev. Med. Devices. , 9(6), 577-594, doi:10.1586/erd.12.51.
  • Feng, R., Xenos, M., Girdhar, G., Davenport, J., Deng, Y., Bluestein, D. (2012) Viscous Flow Simulation in a Stenosis Model Using Discrete Particle Dynamics: A Comparison Between DPD and CFD. J. Biomechanics and Modeling in Mechanobiology. Vol. 11(1-2), 119-129, DOI: 10.1007/s10237-011-0297-z.
  • Rambhia, S.H., Liang, X. Xenos, M. Alemu, Y., Maldonado, N., Kelly, A., Chakraborti,S., Weinbaum, S., Cardoso, S., Einav, S., Bluestein, D. (2012) Microcalcifications Increase Coronary Vulnerable Plaque Rupture Potential: A Patient Based Micro-CT Fluid-Structure Interaction Study. Annals of Biomedical Engineering. Vol. 40 (7), 1443-1454, DOI: 10.1007/s10439-012-0511-x.
  • Peter, D., Alemu., Y., Xenos, M., Weisberg, O., Avneri, Y., Eshkol, M., Oren, T., Elazar, M., Assaf, Y., Bluestein, D. (2012) Fluid Structure Interaction (FSI) with Contact Surface Methodology for Evaluation of Endovascular Carotid Implants for Drug-Resistant Hypertension Treatment. J. Biomechanical Eng., Apr;134(4):041001-10.
  • Claiborne T.E., Girdhar G., Gallocher-Lowe S., Sheriff J., Kato Y.P., Pinchuk L., Schoephoerster R.T., Jesty J., Bluestein D. (2011) Thrombogenic Potential of Innovia Polymer Valves versus Carpentier-Edwards Perimount Magna Aortic Bioprosthetic Valves. ASAIO J., 57(1), pp. 26-31.
  • Xenos, M. Alemu, Y., Zamfir, D., Einav, S., Ricotta, J.J., Labropoulos, N., Tassiopoulos, A., Bluestein, D. (2010) The Effect of Angulation in Abdominal Aortic Aneurysms: Parametric Study With FSI Simulations Medical & Biological Engineering & Computing, 48:1175–1190.
  • Alemu, Y., Girdhar, G., Xenos, M., Sheriff, J., Jesty, J., Einav, S., Bluestein, D. (2010) Design Optimization of a Mechanical Heart Valve for Reducing Valve Thrombogenicity – a Case Study with ATS valve. ASAIO J, 56(5):389-396.
  • Xenos, M., Rambhia, S.H., Alemu, Y., Einav, S., Ricotta, J.J., Labropoulos, N., Tassiopoulos, A., Ricotta, J. J., Bluestein, D. (2010) Patient Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling, Annals of Biomedical Engineering, , Vol. 38, No. 11, pp. 3323–3337.
  • Yamaguchi, T., Ishikawa T. Imai, Y., Matsuki, N., Xenos, M., Deng, Y., Bluestein, D. (2010) Particle Based Methods for Multiscale Modeling of Blood Flow in the Circulation and in Devices– Challenges and Future Directions. Annals of Biomedical Eng., Vol. 38, No. 3, pp. 1225–1235.
  • Xenos, M., Girdhar, G., Alemu, Y., Jesty, J., Slepian, M.J., Einav, S., Bluestein, D. (2010) Device Thrombogenicty Emulator (DTE) − Design optimization Methodology for Cardiovascular Devices: A Study in Two Bileaflet MHV Designs. J. Biomechanics,s, 43: 2400–2409.
  • Bluestein, D., Chandran, K.B. Manning, K.B. (2010) Towards Non-thrombogenic Performance of Blood Recirculating Devices. Annals of Biomedical Eng., Vol. 38, No. 3, pp. 1236–1256.
  • Sheriff, J., Bluestein, D., Girdhar, G., Jesty, J. (2010) Brief Exposure to High Shear Stress Sensitizes Platelets to Subsequent Low-Shear Conditions. Annals of Biomedical Engineering, Vol. 38, No. 4, pp. 1442-1450
  • Einav, S., Gharib, M., Bluestein, D. (2010) Fifth International Biofluid Mechanics Symposium: Position Papers and Key Challenges: Pasadena, March 28–30, 2008 Annals of Biomedical Engineering, Vol. 38, No. 3, pp. 1162–1163.
  • Morbiducci, U., Ponzini, R., Nobili, M., Massai, D., Monteviecchi, F.M., Bluestein, D., Redaelli, A. (2009) Blood damage safety of prosthetic heart valves. Shear induced platelet activation and local flow dynamics: a fluid–structure interaction approach. J. Biomechanics, 42 (12): 1952-1960.
  • Xenos, Rambhia, S., Alemu, Y., Einav, S., Ricotta, J., Labropoulos, N., Apostolos, T., Bluestein, D. (2009) Mimics Based Image Reconstruction Augments Diagnosis and Management of Vascular Pathologies: A Study of ruptured Abdominal Aortic Aneurysms. Mimics Innovation Awards 2009, http://uc.materialise.com/mimics/mia2009
  • Rissland, P., Alemu, Y., Einav, S., Ricotta, J., Bluestein, D. (2009) Abdominal Aortic Aneurysm Risk of Rupture- Patient Specific FSI simulations Using Anisotropic Model. J. Biomech. Eng., 131, 031001 (March 2009) (10 pages)
  • Bluestein, D., Dumont, K., De Beule, M., Ricotta, J., Impellizzeri, P., Verhegghe, B., Verdonck, P. (2009) The Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm on Risk of Rupture - a Patient Specific Modeling Approach. J. Computer Methods Biomech. Biomed. Eng., 12(1):73-81.
  • Claiborne, T. E., Bluestein, D., Schoephoerster, R.T. (2009) Development and evaluation of a novel artificial catheter deliverable prosthetic heart valve and method for in vitro testing, Intl. J. Artif. Organs, 32(5):262-71.
  • Ricotta, J.J., Pagan, J., Xenos, M., Alemu, Y., Einav, S., Bluestein, D. (2008) Cardiovascular disease management: the need for better diagnostics by personalized computer models. Medical & Biological Engineering & Computing, 46(11):1059-68.
  • Girdhar, G., Sulan, X., Bluestein, D., Jesty, J. (2008) Low-nicotine cigarettes substantially increase platelet activation in smokers. Nicotine and Tobacco Research, 10(12), pp. 1-8.
  • Girdhar, G., Xu, S., Jesty, J., Bluestein, D. (2008) In-vitro model of platelet-endothelial activation due to cigarette smoke under cardiovascular circulation conditions. Annals of Biomedical Eng., Vol. 36, No. 7, pp. 1142–1151.
  • Yared, A. and Bluestein, D. (2007) Flow induced platelet activation and damage accumulation in a mechanical heart valve – numerical studies. Artificial Organs, 31(9):677–688.
  • Dumont, K., Vierendeels, J., van Nooten, G., Verdonck, P., Bluestein, D. (2007) Comparison of the Hemodynamic and Thrombogenic Performance of Two Bileaflet Mechanical Heart Valves using a CFD/FSI model. J. Biomech. Eng., 129; 558-565.
  • Raz, S., Yared, A., Einav, S., Bluestein, D. (2007) Flow Induced Platelet Activation in Models of Arterial Stenosis. Annals of Biomedical Eng. Vol. 35, No. 4, pp. 493–504.
  • Yin, W., Krukenkamp, I.B., Saltman, A.E., Gaudette, G., Suresh, K., Bernal, O., Jesty, J., Bluestein, D. (2006) The Thrombogenic Performance of a St. Jude Bileaflet MHV in a Sheep Model. ASAIO J. Vol. 52(1), 28-33.
  • Bluestein, D. (2006) Towards Optimization of the Thrombogenic Potential of Blood Recirculating Cardiovascular Devices Using Modeling Approaches. Expert Rev. Medical Devices, 3(3), 267-270.
  • Zhou, M. Ladeinde, F., Bluestein, D. (2006) The flow of a power-law fluid in the near-wake of a flat plate. Physics of Fluids, 18,088102-1-4.
  • Dumont, K., Vierendeels, J., van Nooten, G., Verdonck, P., Bluestein, D. (2007) Comparison of the Hemodynamic and Thrombogenic Performance of Two Bileaflet Mechanical Heart Valves using a CFD/FSI model. J. Biomech. Eng., 129; 558-565.
  • Yin, W., Krukenkamp, I.B., Saltman, A.E., Gaudette, G., Suresh, K., Bernal, O., Jesty, J., Bluestein, D. (2006) The Thrombogenic Performance of a St. Jude Bileaflet MHV in a Sheep Model. ASAIO J. Vol. 52(1), 28-33
  • Yin, W., Gallocher, S., Pinchuk, L., Schoephoerster, R.T., Jesty, J., Bluestein, D. (2005) Flow Induced Platelet Activation in a St. Jude MHV, a Trileaflet Polymeric Heart Valve and a St. Jude Tissue Valve. Artificial Organs. 29(10):826–831.
  • Bluestein, D., Moore. J.E. (2005) Biofluids Educational Issues: An Emerging Field Aims to Define Its Next Generation. Annals of Biomedical eng., Vol. 33, No. 12: 1674 – 1680.
  • Schulz-Heik, K., Ramachandran, J., Bluestein, D., and Jesty, J. (2005) The extent of platelet activation under shear depends on platelet count: differential expression of anionic phospholipid and factor Va. Pathophysiology of Haemostasis and Thrombosis, Vol. 34, No. 6, 255-262.
  • Dumont, K., Impellizeri, P., Ricotta, J., Alemu, Y., Bluestein, D. (2005) Assessment of fluid wall shear stress and vessel wall stress in an 'ideal' atherosclerotic plaque model. Comput Methods Biomech Biomed Engin. Supp 1: p. 91-2.
  • Yin, W., Yared., A., Jesty, J., Affeld, K., Bluestein, D. (2004) Flow Induced Platelet Activation in Bileaflet and Monoleaflet Mechanical Heart Valves in a Left Ventricular Assist Device. Annals of Biomedical eng., Vol.32, No. 8, 1058-1066.
  • Bluestein, D., Yin, W., Affeld, K., Jesty, J., (2004) Flow-Induced Platelet Activation in a Mechanical Heart Valve. J. Heart Valve Dis, Vol. 13, No. 3, 501-508.
  • Bluestein, D. (2004) Research Approaches for Studying Flow Induced Thromboembolic Complications in Blood Recirculating Devices. Expert Rev. Medical Devices, 1(1), 65-80.
  • Rubenstein, D., Jesty; J., Bluestein; D (2004) The Effects of Mainstream and Sidestream Cigarette Smoke Extracts and Nicotine on Platelet Activation under Static and Dynamic Flow Conditions. Circulation 109:78-83.
  • Ramachandran, J., Rubenstein, D., Bluestein, D., Jesty, J. (2004) Activation of platelets exposed to shear stress in the presence of smoke extracts of low-nicotine and zero-nicotine cigarettes: the protective effect of nicotine. Nicotine and Tobacco Research, 6(5), 835–841.
  • Bluestein D, Li, Y, and Krukenkamp, IB. (2003) Erratum to Free Emboli Formation in the Wake of Bi-Leaflet Mechanical Heart Valves and the Effects of Implantation Techniques. J. Biomechanics, 36 1065-1066.
  • Jesty, J., Yin, W., Perrotta, P., Bluestein, D. (2003) Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time. Platelets, 14, 11–17.
  • Adam J. Singer, Erik S. Mittra, Danny Bluestein, Judd E. Hollander (2002) Simulated wound irrigation impact pressures. Journal of Trauma, Critical Care, and Emergency Medicine, 3(1) 9-16.
  • Bluestein, D. (2002) Drug Delivery - Engineering Principles for Drug Therapy. The Quarterly Review of Biology, Vol. 77, 492.
  • Bluestein D, Li, Y, and Krukenkamp, IB. (2002) Free Emboli Formationin the Wake of Bi-Leaflet Mechanical Heart Valves and the Effects of Implantation Techniques. J. Biomechanics, 35(12) 1533-1540.
  • Bluestein D., Rambod, E. and Gharib, M. (2000) Vortex shedding as a mechanism for free emboli formation in mechanical heart valves. J. Biomech. Engr., Vol. 122, pp. 125-134.
  • Bluestein, D. (2000) Stent-induced thromboembolism. Annals of Biomedical Engineering, Vol. 28:3. 346-348.
  • Jesty, J. and Bluestein, D. (1999) The Use of Acetylated Prothrombin as a Substrate in the Measurement of the Procoagulant Activity of Platelets: Elimination of the Feedback Activation of Platelets by Thrombin. Analyt. Biochem., Vol. 272, No. 1, pp. 64-70.
  • Bluestein, D., Gutierrez, C., Londono, M. and Schoephoerster, R.T. (1999) Vortex shedding in arterial stenosis and its relevance to mural platelet deposition. Annals of Biomedical Engineering, Vol. 27:6, pp. 763-773.
  • Bluestein, D., Niu, L., Schoephoerster, R.T. and Dewanjee, M.K. (1997) Fluid mechanics of flow through a stenosis: relationship to the development of mural thrombus. Annals of Biomedical Engineering, Vol. 25, No. 2, pp. 344-356.
  • Bluestein, D., Niu, L., Schoephoerster, R.T., and Dewanjee, M.K. (1996) Steady flow in an aneurysm model: Correlation between numerical simulation and blood platelet deposition. J. Biomech. Engr., Vol. 118, No.3, pp. 280-286.
  • Bluestein, D. and Einav, S. (1995) The Effect of Varying Degrees of Stenosis on the Characteristics of Turbulent Pulsatile Flow Through Heart Valves. J. Biomechanics, Vol. 28, No. 8, pp. 915-924.
  • Bluestein, D., Einav, S. and Hwang, N.H.C. (1994): A Squeeze Flow Phenomenon at the Closing of a Bileaflet Mechanical Heart Valve. J. Biomechanics, Vol. 27, No. 11, pp. 1369-1378.
  • Bluestein, D. and Einav, S. (1994): Transition to Turbulence in Pulsatile Flow Through Heart Valves- A Modified Stability Approach. J. Biomech. Eng., Vol. 116, No. 4, pp. 477-487.
  • Bluestein, D., Viscarra, H., Niu, L. and Schoephoerster, R.T. (1994) Fluid Mechanics of Arterial Stenosis and Aneurysm: Relationship to Blood Platelet Deposition on the Wall. CSCE Eng. Mech., vol. IV, pp. 115-120.
  • Bluestein, D. and Einav, S. (1994): A Modified Stability Diagram of Pulsatile Flow Through Heart Valves Based on Improved Spectral Estimates of LDA Data. ASME FED Laser Anemometry: Advances and Applications, Vol. 191, pp. 125-133.
  • Bluestein, D. and Einav, S. (1993): Spectral Estimation and Analysis of LDA Data in Pulsatile Flow Through Heart Valves. Experiments in Fluids, Vol. 15, pp. 341-353.
  • Bluestein, D., and Hwang, N.H.C. (1993) The Squeeze Flow Field of a Mechanical Heart Valve at Closure. Annals of Biomedical Engineering, 1993; 21(S1):23.
  • Bluestein D., Menon, S., Wu, Z.J., S., Haubold, A., Armitage, T.L. and Hwang, N.H.C. (1993): The Closing Behavior of a New Bileaflet Mechanical Heart Valve. ASAIO Journal, Vol. 39 (3), pp. 398-402.
  • Bluestein, D., Einav, S. and Hwang, N.H.C.(1992) Stability of Flow Through Heart Valves: A Comparison Between the Traditional Approach and a Novel Approach. ASME BED Advances in Bioengineering, Vol. 22, pp. 427-431.
  • Bluestein, D. and Einav, S.(1986): The Effect of a Plane Wall in the Discharge of a Swirling Jet, Laser Anem. Fluid Mech., Vol. 3, pp. 151-154.


  • “Methods, devices, and systems for microfluidic stress emulation.” US provisional patent application No. 62/043,977, 9/02/2014.
  • "Polymeric prosthetic heart valve designed for optimized durability and hemodynamics." US provisional patent application No. 61/546,832, 10/13/2011.
  • "An assay of the activation state of platelets." International patent application disclosure date 7/14/00 (based on US provisional patent application No. 60/143,702).

Funding Agencies

  • National Institutes of Health
  • American Heart Association, NY Affiliate
  • American Heart Association, National
  • Binational Science Foundation
  • SOM Stony Brook
  • The Whitaker Foundation
  • National Science Foundation
  • Cariplo Foundation