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  • Biofluids Laboratory
Contact Info

Ki H. Chon

T: 631.444.7286
F: 631.444.3432
E: ki.chon@sunysb.edu

Office:
HSC T18 Room 030
Stony Brook, NY
11794-8181

Ki H. Chon

     

Research Focus

The cardiac autonomic nervous system is responsible for maintaining proper homeostasis, or balance, of the cardiovascular system. One of our major areas of research is to detect, quantify, and interpret differences in dynamic characteristics of the cardiac autonomic nervous system between normal and diseased subjects, in an attempt to find a marker for increased risk of sudden cardiac death. Identifying and quantifying differences in the dynamic characteristics of autonomic function between normal and diseased conditions may lead to a better understanding of the role of autonomic function imbalance in diseased conditions, and should have important clinical diagnostic and prognostic applications. Another active research area is the development of computational modeling approaches to understand differences in dynamics of renal autoregulatory mechanisms between normotensive and hypertensive conditions. For both areas of research, we are developing novel linear and nonlinear signal processing techniques that can be successfully applied to experimental data to achieve the research objectives.

Fig. 1 Time-varying Impulse Response Functions of Renal Blood Flow: Normotensive (Top Panel) and Hypertensive Rats (Bottom Panel).

Education
  • Ph.D. - Biomedical Engineering, University of Southern California, Los Angeles, California, 1993
  • M.S. - Electrical Engineering (Signal Processing), University of Southern California, Los Angeles, California, 1991
  • M.S. - Biomedical Engineering, University of Iowa, Iowa City, Iowa, 1988
  • B.S. - Electrical Engineering, University of Connecticut, Storrs, Connecticut, 1985

Academic Appointments

  • 2007-present Professor, Department of Biomedical Engineering, Stony Brook University
  • 2002-2007 Associate Professor, Department of Biomedical Engineering, Stony Brook University
  • 2002 (January 1) Associate Professor, Dept. of Electrical Engineering, City College of New York, New York, NY.
  • 2002 (September 1) Early tenure granted. City College of New York, New York, NY.
  • 1998-2001 Assistant Professor, Dept. of Electrical Engineering, City College of New York, New York, NY.
  • 1997-1998 Research Assistant Professor, Dept. of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI.
  • 1994-1997 National Research Service Individual Postdoctoral Fellowship Award from the National Institute of Health Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA.
  • 1993-1994 Postdoctoral Associate, Dept. of Biomedical Engineering, University of Southern California, Los Angeles, CA.
  • 1989-1993 Research Assistant, Biomedical Simulations Resource, University of Southern California, Los Angeles, CA.
  • 1990-1993 Research Associate, Cedars-Sinai Medical Center, Division of Pulmonary Physiology, Los Angeles, CA.
  • 1987-1988 Graduate Research Assistant, University of Iowa, Iowa City, IA.
  • 1987-1988 Research Assistant, University of Iowa Hospital & Clinics, Department of Neuro-Ophthalmology.

Honors
  • 2006 - Outstanding Service Award, Dept. of BME, SUNY at Stony Brook
  • 2000-2002 - Harold Shames Outstanding Faculty Award, City College of New York
  • 1997-1998 - Young Investigator Award, National Kidney Foundation
  • 1994-1997 - Individual National Research Service Award, NIH
  • 1981-1984 - Connecticut State Scholar, University of Connecticut

Professional Activities

Editorial Positions
  • 2008 - Present: Associate Editor, IEEE Transactions on Biomedical Engineering Letters
  • 2007 - Present: Associate Editor, IEEE Transactions on Biomedical Engineering
  • 2007 - Present: Associate Editor, International J. Bioelectromagnetism
  • 2006 - Present: Associate Editor, Recent Patents on Engineering

Conference Organization of National and International Scientific Meetings

  • 2009 - Conference Chair, 6th International Workshop on Biosignal Interpretation, Yale University, New Haven, CT, June 24-26, 2009
  • 2008, 2007, 2006, 2003 - Theme Chair, Biosignal Processingm Annual International Conference of the IEEE EMBS
  • 2008 - Scientific Committee Member, European Study Group on Cardiovascular Oscillations, Parma, Italy, April
  • 2006 - Program Co-Chair, 28th Annual International Conference of the IEEE EMBS, New York, NY, September, 2006
  • 2006 - Scientific Committee Member, European Study Group on Cardiovascular Oscillations, Jena, Gernmany
  • 2005 - Scientific Committee Member, 5th International Workshop on Biosignal Interpretation, Tokyo, Japan, September, 2005

Publications

 Refereed Journal Publications (last 5 years)
  • Bai, Y., R. Mahon, J. White, P. Brink, and K.H. Chon, Impariment of autonomic nervous function during decompression sickness in swine. J. Appl. Physiol., In Press.
  • Betzel, J., R. Mukkamala, G. Baselli, and K.H. Chon, Modeling and disentangling physiological mechanisms: Linear and nonlinear identification techniques for analysis of cardiovascular regulation.  Philosophical Trans. Royal Soc. A., In Press.
  • Faes, L., H. Zhao, K.H. Chon, and G. Nollo, Time-varying surrogate data to assess nonlinearity in nonstationary time series: application to heart rate variability. IEEE Trans. BME, In Press.
  • Faes, L., K.H. Chon, and G. Nollo. A method for the time-varying nonlinear prediction of complex nonstationary biomedical signals.  IEEE Trans. BME Letters, In Press.
  • Mujica-Parodi, L., M. Korgaonkar, B. Ravindranath, T. Greenberg, D. Tomasi, M. Wagshul, B. Ardekani, D. Guilfoyle, S. Khan, Y. Zhong, K. Chon, and D. Malaspina, Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults, Human Brain Mapping, 30:47-58, 2009.
  • Chon, K.H., Y.M. Zhong, W.C. Cupples, and L.C. Moore: Analysis of nonstationarity in renal autoregulation mechanisms using time-varying transfer and coherence functions.  Am. J. Physiol. 295:R821-828, 2008.
  • Bai, Y., K. Siu, S. Ashraf, L. Faes, G. Nollo, and K.H. Chon, The presence of nonlinear coupling in healthy subjects are absent in acute myocardial infarction subjects. Am. J. Physiol. 295:H578-586, 2008.
  • Lu, S., X. Chen, J.K. Kanters, I.C. Solomon, and K.H. Chon, Automatic Selection of the Threshold Value for Approximate Entropy.  IEEE Trans. BME, 55:1966-1972, 2008.
  • Siu, K, J.M. Ahn, K.H. Ju, M. Lee, K. Shin and K.H. Chon, Statistical approach to quantify the presence of quadratic phase coupling using the bispectrum.  IEEE Trans. BME, 55:1512-1520, 2008.
  • Lu, S., H. Zhao, K. Ju, K.S. Shin, M.H. Lee, K. Shelley and K. H. Chon, Can photoplethysmography variability serve as an alternative approach to obtain heart rate variability information?  J. Clinical Monitoring & Computing, 22:23-29, 2008
  • Faes, L., G. Nollo, and K.H. Chon, Assessment of Granger Causality by Nonlinear ARMA Model Identification: Application to Short-Term Cardiovasular Data.  Ann BME, 36:381-395, 2008.
  • Chen, X., K.H. Chon, and I.C. Solomon: Fast oscillatory rhythms in inspiratory motor discharge: a mathematical model. Adv. Exp. Med. Biol., 605:401-406, 2008.
  • Zhao, H., W.A. Cupples, K.H. Ju, and K.H. Chon, Time-varying causal coherence function: application to renal blood pressure and flow data. IEEE Trans BME, 54:2142-2150, 2007.
  • Zhong, Y., Y. Bai, B. Yang, K. Ju, K. Shin, M. Lee, K. Jan, K.H. Chon, Autonomic Nervous Nonlinear Interactions Lead to Frequency Modulation between Low- and High-Frequency Bands of the Heart Rate Variability Spectrum, Am. J. Physiol., 293:1961-1968, 2007.
  • Zhong, Y., K.M. Jan, K.H. Ju, and K.H. Chon, Representation of time-varying nonlinear systems with time-varying principal dynamic modes.  IEEE Trans BME, 54:1983-1992, 2007.
  • Yao, M. K.H. Chon, and S. Zhen.  E-letter in response to: Integration of Technologies for Constant Monitoring of Exposure. Science, 316:695-696, June 14, 2007.
  • Wang, H., K. Ju, and K.H. Chon. Closed-loop Nonlinear System Identification via the Vector Optimal Parameter Search Algorithm: Application to Heart Rate Baroreflex Control.  Med Eng Phys. May;29(4):505-15, 2007.
  • Zhao, H., W.A. Cupples, K. Ju, and K.H. Chon: Time-varying causal coherence function and its application to renal blood pressure and blood flow data, Methods of Information in Medicine, 46(2):102-9, 2007
  • Zhong, Y. K. Jan, and K.H. Chon:  Frequency modulation between low- and high-frequency components of the heart rate variability spectrum, Biomed Tech., 51:251-254, 2006.
  • Zhong, Y., K. Jan, K. Ju, K. Jan and K.H. Chon.  Quantifying Cardiac Sympathetic and Parasympathetic Nervous Activities Using Principal Dynamic Modes Analysis of Heart Rate Variability.  Am. J. Physiol(Heart & Circ), 291:H1475-83, 2006.
  • Raghavan, R., X. Chen, K.P. Yip, D.J. Marsh, and K.H. Chon: Interactions between TGF-dependent and myogenic oscillations in tubular pressure and whole kidney blood flow in both SDR and SHR, Am. J. Physiol., Renal Physiology, 290:F720-F732, 2006.  
  • Wang, H., K. Siu, K. Ju, and K.H. Chon: A high resolution approach to estimating time-frequency spectra and their amplitudes, Ann BME, 34:326-338, 2006.   
  • Feng, L., K. Siu, L.C. Moore, D.J. Marsh, and K.H. Chon: A robust method for detection of linear and nonlinear interactions: application  to renal blood flow dynamics, Anne BME, 34:339-353, 2006.   
  • Shi, Y., X. Wang, K.H. Chon, and W.A. Cupples: Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide.  Am. J. Physiol., Regul Integr Comp Physiol, 290:R982-R991, 2006.                                        
  • Chon, K.H., Y. Zhong, H. Wang, K. Ju, and K. Jan.  Separation of dynamic components of heart rate variability by principal dynamic modes.  Nonlinear Dynamics, Psychology, and Life Sciences  10:163-185, 2006.
  • Zhao, H., S. Lu, R. Zou, K. Ju, and K.H. Chon.  Estimation of time-varying coherence function using time-varying transfer functions. Ann BME  33:1582-1594, 2005.     
  • Feng, L., K. Ju, and K.H. Chon.  A method for segmentation of switching dynamic modes in time series, IEEE Trans. Systems, Man & Cyber. Part B, 35:1058-1964, 2005.                                     
  • Chon, K.H., H. Zhao, and R. Zou.  Multiple time-varying dynamic analysis using multiple sets of basis functions. IEEE Trans. BME  52:956-960, 2005.
  • Wang, H., K. Siu, K. Ju, L.C. Moore, and K.H. Chon.  Identification of transient renal autoregulatory mechanisms using time frequency spectral techniques.  IEEE Trans. BME  52:1033-1039, 2005. 
  • Chen, X., K.H. Chon, and I.C. Solomon.  Chemical activation of pre-Bötzinger complex in vivo reduces respiratory network complexity.  Am. J. Physiol. Reg, Integr Comp Physiol.  288:R1237-R1247, 2005.
  • O'Neal, M.H., III, E.T. Spiegel, K.H. Chon, and I.C. Solomon.  Time-frequency representation of inspiratory motor output in anesthetized C57BL/6 mice in vivo.  J. Neurophysiol.  93:1762-1775, 2005.  (Cover Illustration, February, vol. 93, no. 2)                              
  • Marsh, D.J., O. Sosnovtseva, K.H. Chon, and N.H. Holstein-Rathlou.  Nonlinear interactions in renal blood flow regulation.  Am. J. Physiol. . Reg, Integr Comp Physiol.  288:R1143-1159, 2005. 
  • Hoyer, D., B. Pompe, K.H. Chon, H. Hardraht, C. Wicher, and U. Zwiener.  Mutual information function assesses autonomic information flow of heart rate dynamics at different time scales.  IEEE Trans. BME  52:584-92, 2005.                                       
  • Chon, K.H., R. Raghavan, Y.M. Chen, D.J. Marsh, and K.P. Yip.  Interactions of TGF-dependent and myogenic oscillations in tubular pressure.  Am. J. Physiol.  288:F298-307, 2005.                                      
Book Chapters
  • Holstein-Rathlou, N.H., K.H. Chon, D.J. Marsh and V.Z. Marmarelis: Model of renal blood flow autoregulation, in: Modelling the Dynamics of Biological Systems, edited by E. Mosekilde and O.G. Mouritsen, pp. 167-185, Springer-Verlag Press, Berlin, 1995.
  • Chon, K.H., N.H. Holstein-Rathlou, D.J. Marsh and V.Z. Marmarelis: Parametric and nonparametric nonlinear modeling of renal autoregulation dynamics, In: Advanced Methods of Physiological System Modeling, Vol. III, edited by V.Z. Marmarelis, pp. 195-210, Plenum Press, New York, 1994.

Grants

 Active Grants
  • 2008-2011; Office of Naval Reserach; Title: Noninvasive diagnosis and real-time evaluation of the effects of hyperbaric dive environments on the autonomic nervous system, utilizing principal dynamic mode analysis. PI: Ki H. Chon
  • 2008-2009; Ultraradian Diagnostics/NYSTAR; Title: Continuous glucose monitoring. PI: Ki H. Chon
  • 2004-2009; NIH (NIDDK); Title: Graduate training in systems physiology and analysis. Co-PI: Ki H. Chon

Patents

  • Extraction of respiratory rate from pulse oximeter recordings, Patent pending
  • Apparatus and method for automatic real time detection of atrial fibrillation, and turning points algorithm for detection of alternans in the time domain and for identification of random rhythms, Patent pending
  • Methods and apparatus for detection and treatment of autonomic system imbalance, Patent pending