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Contact Info

Michael Hadjiargyrou

T: 631.632.1480
F: 631.632.3222
E: Michael.Hadjiargyrou
@sunysb.edu

Office:
Bioengineering Room 101
Stony Brook, NY
11794-5281



Michael Hadjiargyrou

     

Research Focus

The overall goal of this laboratory is to implement innovative approaches for engineering new musculoskeletal tissue utilizing knowledge derived from molecular and cellular biology and biomaterials. More specifically, we are actively involved in understanding the molecular mechanisms that underlie musculoskeletal development and regeneration. Previously, we have used fracture repair as an example to study tissue regeneration. The repair of a fractured bone is a complex biological event that essentially recapitulates embryonic development and requires the orchestration of a number of different cell types undergoing proliferation, migration, adhesion and differentiation, all under the direct control of a host of different genes. Understanding the temporal and spatial expression of these genes during the progression of a healing callus will ultimately enable us to comprehend the essential processes of inflammation, chondrogenesis, ossification, and remodeling. The latest methods in molecular and cellular biology are applied in the pursuit of gene discovery, gene structure and function analysis, expression studies and functional perturbations. By identifying and studying genes that play essential roles during tissue repair, we hypothesize that this knowledge will facilitate a greater understanding in our ability to elucidate the process of musculoskeletal development and regeneration and identify ideal gene candidates for possible therapeutic intervention via the use of biomaterials.

 

Education
  • B.A. - Biology/Philosophy, City University of New York, New York City, 1986
  • M.A. - Biology, City University of New York, New York City, 1988
  • Ph.D. - Molecular Biology, City University of New York, New York City, 1992
  • Post-Doc - Cell/Molecular Biology, California Institute of Technology, Pasadena, CA, 1992-96

Research and Professional Experience
  • 1984 Student researcher, Rusk Institute of Rehabilitation, New York University Medical Center
  • 1984 - 86 Student researcher, Laboratory of Clinical Microbiology and Immunology, Rockefeller University
  • 1987-88 Laboratory Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-91 Recitation Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-92 Graduate student, Department of Biological Sciences, Hunter College, CUNY
  • 1992-95 Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1995-96 Senior Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1996-98 Research Assistant Professor, Department of Orthopaedics and Program in Biomedical Engineering, State University of New York at Stony Brook
  • 1998-2003 Assistant Professor, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2000-present Faculty Member, Graduate Program in Genetics, State University of New York at Stony Brook
  • 2003-present Associate Professor, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2005-2007 Graduate Program Director, Department of Biomedical Engineering, State University of New York at Stony Brook
  • 2007- 2010 Associate Vice President for Research, State University of New York at Stony Brook
  • 2007-2010 Member, Advocacy Committee, American Society for Bone and Mineral Research, Washington, DC
  • 2007-present Associate Editor, Journal of Biomedical Nanotechnology
  • 2008-present Editorial Advisory Board, The Open Nanomedicine Journal
  • 2008-present Editorial Advisory Board, The Open Bone Journal
  • 2008-present Faculty Member, Center for Medical Humanities, Compassionate Care, and Bioethics, Stony Brook University, Stony Brook, NY

Honors
  • 1984 New York University Medical Center, DeWitt Wallace Reader's Digest Fellow
  • 1986 City University of New York, The Presidential Prize for Academic Excellence in Philosophy
  • 1988-91 City University of New York, Graduate Teaching Fellowship
  • 1989 City University of New York, The Beatrice Goldstein Konheim Graduate Scholarship in the Life Sciences
  • 1990 Hellenic University Club of New York,The Frederick E.G. Valergakis Award
  • 1992-93 California Institute of Technology, American Heart Association Research Fellowship
  • 1993-96 California Institute of Technology, NIH NRSA
  • 2001 Outstanding Teacher of the Year, Department of Biomedical Engineering, SUNY at Stony Brook
  • 2002 Who's Who in Engineering Education
  • 2002 Who's Who in Medicine and Healthcare
  • 2003 Who's Who in America
  • 2003 Who's Who in Science and Engineering
  • 2003 Outstanding Teacher of the Year, Department of Biomedical Engineering, SUNY at Stony Brook
  • 2005 First Patent Honoree, Research Foundation of New York
  • 2007 Outstanding Service Award, Department of Biomedical Engineering, SUNY at Stony Brook
  • 2008 President's Award for Team Achievement (Science And Research Awareness Series [SARAS])
  • 2008 Most Cited Paper Award for 2004, Journal of Controlled Release

Membership in Professional Societies
  • 1997-present Member, American Society for Bone and Mineral Research
  • 1997-present Member, Federation of American Societies for Experimental Biology

Publications

 Selected Research Articles
  • Hadjiargyrou, M. and Patterson, P.H. (1995) An anti-CD9 monoclonal antibody promotes adhesion and induces proliferation of Schwann cell in vitro. J. Neurosci. 15:574-583.
  • Hadjiargyrou, M., Kaprielian, Z., Kato, N. and Patterson, P. H. (1996) Association of the tetraspan protein CD9 with integrins on the surface of S 16 Schwann cells. J. Neurochem. 67, 2505-2513.
  • Hadjiargyrou, M., Halsey, M., Ahrens, W., Rightmire, E., McLeod, K.J. and Rubin, C.T. (1998). Cloning of a novel cDNA expressed during the early stages fracture healing. Biochem. Biophys. Res. Com. 249:879-884.
  • Hadjiargyrou, M., Ahrens, W. and Rubin, C.T. (2000) Expression of the chondrogenic and angiogenic growth factor CYR61 during fracture repair. J. Bone Miner. Res. 15:1014-1023.
  • Hadjiargyrou, M., Rightmire, E. P., Ando, T. and Lombardo F. T. (2001) The E11 osteoblastic lineage marker is differentially expressed during fracture healing. Bone 29:149-154.
  • Hadjiargyrou, M., Lombardo, F., Zhao, S., Ahrens, W., Joo, J., Ahn, H., Jurman, M., White, D.W. and Rubin, C.T. (2002) Transcriptional profiling of bone regeneration: Insight into the Molecular Complexity of Wound Repair. J. Biol. Chem. 277:30177-30182.
  • Luu, Y.K., Kim, K., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2003) Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J. Control Release 89:341-353.
  • Kim, K., Yu, M., Zong, X., Chiu, J., Fang, D., Seo, Y.S., Hsiao, B., Chu, B., Hadjiargyrou, M. (2003) Control of degradation rate and hydrophilicity in electrospun non-woven poly(D,L-lactide) nanofiber scaffolds for biomedical applications. Biomaterials 24:4977-4985.
  • Lombardo, F., Komatsu, D., and Hadjiargyrou, M. (2004) Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during bone development and regeneration. The FASEB Journal 18:52-61.
  • Komatsu, D. E. and Hadjiargyrou, M. (2004) Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 34:680-688.
  • Kim, K., Luu, Y.K., Chang, C., Fang, D., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2004) Incorporation and Controlled Release of a Hydrophilic Antibiotic Using Poly(lactide-co-glycolide) Based Electrospun Nanofibrous Scaffolds. J. Control. Release 98:47-56.
  • Gersch, R., Lombardo, F., McGovern, S., and Hadjiargyrou, M. (2005) Re-activation of Hox gene expression during bone regeneration. J. Orthop. Res. 23: 882-890.
  • Liang, D., Luu, Y.K., Kim, K., Hsiao, B.S., Hadjiargyrou, M. and Chu, B. (2005) In Vitro Non-viral Gene Delivery with Nano-fibrous Scaffolds. Nucl. Acids Res. 33:e170.
  • Zhong, N., Gersch, P.R., and Hadjiargyrou, M. (2006) Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone 39:5-16.
  • Liang, D., Luu, Y.K., Kim, K., Hsiao, B.S., Hadjiargyrou, M. and Chu, B. (2005) In Vitro Non-viral Gene Delivery with Nano-fibrous Scaffolds. Nucl. Acids Res. 33:e170.
  • Liu, C. and Hadjiargyrou, M. (2006) Identification and Characterization of the Mustang Promoter: Regulation by AP-1 during Myogenic Differentiation. Bone 39:815-824.
  • Komatsu, D., Bosch-Marce, M., Semenza, G.L. and Hadjiargyrou, M. (2007) Enhanced Bone Regeneration Associated with Decreased Apoptosis in Mice with Partial HIF-1a Deficiency. J. Bone Miner. Res. 22:366-374.
  • Chiu, J., Liu, C., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2007) Functionalization of Poly(L-lactide) (PLLA) Nanofibrous Scaffolds with Bioactive Collagen Molecules. J. Biomed. Mater. Res. A 83:1117-27
  • Zhi, J., Xu, G., Rubin, C.T. and Hadjiargyrou, M. (2008) The lipogenic gene Spot 14 is activated in bone by disuse, yet remains unaffected by mechanical signals anabolic to the skeleton. Calcif Tissue Int. 82:148-154.
  • Zhu, S., Barbe, M.F., Liu, C., Hadjiargyrou, M., Popoff, S.N., Rani, S., Safadi, F.F. and Litvin, J. (2009) Periostin-like-Factor in Osteogenesis. J Cell Physiol. 218:584-92.
  • Gersch, R.P. and Hadjiargyrou, M. (2009) Mustn1 is expressed during chondrogenesis and is necessary for chondrocyte proliferation and differentiation in vitro. Bone 45:330-338.
  • Mironava, T., Hadjiargyrou, M., Simon, M., Jurukovskic, V. and Rafailovich, M.H.  (2010) Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time. Nanotoxicology 4:120-137.
  • Abdelmagid, S.M., Barbe, M.F., Hadjiargyrou, M., Owen, T.A., Razmpour, R., Rehman S., Popoff, S.N. and Safadi, F.F. (2010) Temporal and spatial expression of osteoactivin during fracture repair. J Cell Biochem. 111:295-309.
  • Liu, C., Gersch, RP, Hawke, T.J. and Hadjiargyrou, M. (2010) Silencing of Mustn1inhibits myogenic fusion and differentiation. Am. J. Physiol. Cell Physiol. 298:C1100-C1108.
  • Ke, F., Luu, YK., Hadjiargyrou, M. and Liang, D. (2010) Characterizing DNA Condensation and Conformational Changes in Organic Solvents. PLoS One 5.e13308.

Book Chapters/Reviews

  • Hadjiargyrou, M., McLeod, K.J., Ryaby J.P. and Rubin, C.T. (1998). Enhancement of fracture healing by low intensity ultrasound. Clin. Ortho. Rel. Res. 355S: S216-S229.
  • Rubin,CT., Bolander, M., Ryaby, JP., and Hadjiargyrou, M. (2001). The use of low intensity ultrasound to accelerate the healing of fractures. J. Bone Joint Surg. 83:259-270.
  • Sommerfeldt, D.W., Hadjiargyrou, M., Rubin, J., and Rubin, C.T. (2002) Clinical Implications of Recent Advances in the Biology and Physiology of Bone (Chapter 1). In Vertebral Osteoporotic Compression Fractures. Marek Szpalski and Robert Gunzburg, Editors. Lippincott Williams & Wilkins, Philadelphia, PA.
  • Hadjiargyrou, M. (2002) Reproduction & Development. The Second Creation: Dolly and the Age of Biological Control. The Quarterly Review of Biology 77:202-203.
  • Chiu, J., Luu, Y.K., Fang, D., Hsiao, B., Chu, B. and Hadjiargyrou, M. (2005) Electrospun nanofibrous scaffolds for biomedical applications. J. Biomed. Nanotech. 1:115-132.
  • Rubin, C.T., Qin, Y. X., Hadjiargyrou, M. and Judex, S. (2005). Bone’s “Preferred Strain History” Provides Insight into a Proposed Common Pathway for the Stimulation of Bone Formation by Distinct Biophysical Signals (Chapter 5). In Physical Regulation of Skeletal Repair. Roy K. Aaron and Mark Bolander, Editors. American Academy of Orthopaedic Surgeons, Rosemont, IL.
  • Hadjiargyrou, M. and Chiu, J. (2008) Enhanced composite electrospun nanofiber scaffolds for use in drug delivery. Expert Opin. Drug Deliv. 5:1093-1106.

Other Publications

  • Hadjiargyrou, M. (1991) “True Communism”, New York Times, letter.
  • Hadjiargyrou, M. (1997) “For US Students, History Doesn’t Pay”, New York Times, letter.
  • Hadjiargyrou, M. (1999) “NATO’s Attack On a Sovereign Nation”, New York Times, letter.
  • Hadjiargyrou, M. (1999) “Buchanan’s New Home”, New York Times, letter.
  • Hadjiargyrou, M. (2000) “Eureka! A Key to the Code of Life”, New York Times, letter.
  • Hadjiargyrou, M. (2001) “Ashcroft and the Divided Senate”, New York Times, letter.
  • Hadjiargyrou, M. (2001) “Did the Gold Medalist Get Extra Help?”, New York Times, letter.
  • Hadjiargyrou, M. (2001) “Stem Cells and Delicate Questions”, New York Times, letter.
  • Hadjiargyrou, M. (2001) “The War, the Press and bin Laden”, New York Times, letter.
  • Hadjiargyrou, M. (2001) “Who Is to Blame in the Mideast?”, New York Times, letter.
  • Hadjiargyrou, M. (2002) “How Should U.S. Answer Hate?”, New York Times, letter.
  • Hadjiargyrou, M. (2002) “Cloning, Science and Morality”, New York Times, letter.
  • Hadjiargyrou, M. (2002) “Not Democrats”, Newsday, letter.
  • Hadjiargyrou, M. (2003) “Business as Usual in Brookhaven”, Long Island Section, New York Times, letter.
  • Hadjiargyrou, M. (2004) “Road to Cloning: Caution Ahead”, New York Times, letter.
  • Hadjiargyrou, M. (2004) “Stem Cells and Moral Questions”, New York Times, letter.
  • Hadjiargyrou, M. (2004) “Science and Politics Collide”, Science Times, New York Times, letter.
  • Hadjiargyrou, M. (2005) “Bending Our Beliefs”, New York Times, letter.
  • Hadjiargyrou, M. (2005) “Funding Grants”, The American Society for Cell Biology Newsletter, letter.
  • Hadjiargyrou, M. (2005) “Shrinking Budgets for Research”, Long Island Section, New York Times, letter.
  • Hadjiargyrou, M. (2005) “Attack on Iraq was About Lies”, Newsday, letter.
  • Hadjiargyrou, M. (2006) “In Iraq, Deadly signs of Civil War”, New York Times, letter.
  • Hadjiargyrou, M. (2006) “’Frankencotton’, the Debate”, Science Times, New York Times, letter.
  • Hadjiargyrou, M. (2006) “’Geo-Green' in 2008?”, New York Times, letter.
  • Hadjiargyrou, M. (2006) “Reconcilling Proof and Belief”, Science Times, New York Times, letter.
  • Hadjiargyrou, M. (2006) “An Unwelcome Discovery”, Magazine, New York Times, letter.
  • Hadjiargyrou, M. (2006) “Federal Help Essential for Scientific Literacy”, Long Island Section, New York Times, letter.
  • Hadjiargyrou, M. (2007) “The Issue: Who Would Lead Best?”, New York Times, letter.
  • Hadjiargyrou, M. (2007) “Stem Cell Hypocrisy”, New York Times, letter.
  • Hadjiargyrou, M. (2007) “To be Young and Liberal in America”, New York Times, letter.
  • Hadjiargyrou, M. (2007) “Good Pig Farming”, New York Times, letter.
  • Hadjiargyrou, M. (2008) “The First Primary: It’s Clinton’s Day”, New York Times, letter.
  • Hadjiargyrou, M. (2008) “Spitzer plan does what feds should do for academia”, Newsday, letter.
  • Hadjiargyrou, M. (2008) “The Nature of Politics”, Science Times, The New York Times, letter.
  • Hadjiargyrou, M. (2008) “The Testing of Barack Obama”, The New York Times, letter.
  • Hadjiargyrou, M. (2008) “Of Diversity and Bacteria”, Science Times, The New York Times, letter.
  • Hadjiargyrou, M. (2008) “She’s New, So the Focus Is on Palin”, The New York Times, letter.
  • Hadjiargyrou, M. (2009) “When You Want Your Dog to Live Forever”, The New York Times, letter.
  • Hadjiargyrou, M. (2009) “Science in a Democracy”, Science Times, The New York Times, letter.
  • Hadjiargyrou, M. "For Teachers, All the Classroom’s a Stage". Science 323:1009, 2009.
  • Hadjiargyrou, M. (2009) “The Keys to Aging”, The New York Times, letter.
  • Hadjiargyrou, M. (2009) "Still hurting from the Bush years", The New York Times/International Herald Tribune.
  • Hadjiargyrou, M. (2009) "Is Happiness Catching?", The New York Times Magazine.
  • Hadjiargyrou, M. (2010) “What to Do About Bankers’ Bonuses”, The New York Times.
  • Hadjiargyrou, M. (2010) "To Transform Health Care in America", The New York Times.
  • Hadjiargyrou, M. (2010) “The Problem of Plagiarism in School”, The New York Times.
  • Hadjiargyrou, M (2010) "Feeding the World", The New York Times.
  • Hadjiargyrou, M (2010) “Overdue for an Apology”, The New York Times/International Herald Tribune.
  • Hadjiargyrou, M (2010) "Investment in the Future", The New York Times.

Patents
  • Cell delivery system comprising a fibrous matrix and cells. Patent #6790455.
  • Cell Storage and Delivery System. United States Patent #20030054035. (Pending).
  • Mustang, a gene and nuclear protein. Patent # 7,238,799.
  • Cell delivery system comprising a fibrous matrix and cells. US Patent (Continuation) #7,323,190.

Funding Sources
  • National Institutes of Health
  • National Aeronautics and Space Administration
  • Aircast Foundation
  • New York Center for Advanced Technology
  • SBU School of Medicine
  • STAR Inc.

Courses
  • BME 304 Genetic Engineering
  • BME 402/608 Contemporary Biotechnology
  • BME 501 Engineering Principles in Cell Biology
  • BME 534 Functional Genomics
  • BME 545/HBY530 Cell Physiology and Biophysics
  • BGE 691 Readings in Genetics
  • MCS2 Medicine in Contemporary Society