Research in the Integrative Skeletal Adaptation and Genetics Laboratory focuses on how organ systems, such as the skeleton, respond to altered functional demand. Specifically, we are combining genetic, molecular, and biomechanical approaches to elucidate how bone regulates its quantity and quality and how mechanical signals may perturb this regulation. Understanding the translation of mechanical input into a biological response requires the rigorous integration of engineering with biology, from the genome to the molecular, cellular, and tissue level. Ultimately, this understanding will lead to the design of interventions that will enhance tissue strength in young adults and prevent the loss of tissue quantity and quality during osteoporosis, aging, or space flight. In contrast to most theories of bone adaptation, we have recently demonstrated that directly inducing tissue deformation is not necessary for mechanical signals to become effective. Indeed, cells can even sense low-level oscillatory accelerations as anabolic and/or anti-catabolic, indicating that biomechanical treatments can be both safe and efficacious.
In vivo microcomputed tomography scans of a circular bony defect that was either left untreated (left image) or subjected to very low levels of oscillatory accelerations for 20 min/d (right image). As early as 4wk, the low-level mechanical signal significantly accelerated bone regeneration in the defect (Hwang et al., Clin Orthop Relat Res 2009).
Education & Training
- 1999-2001 Post-doctoral Research Fellow, Department of Biomedical Engineering (Molecular Biology), Stony Brook University, NY
- 1999 Ph.D., Mechanical Engineering (Biomechanics), University of Calgary, Canada
- 1993 Diplom Ingenieur Universität (Master of Science), Mechanical Engineering, Technical University Munich, Munich, Germany
- 2011–present Professor (tenured), Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY
- 2006–2011 Associate Professor, Department of Biomedical Engineering, State University of New York (SUNY), Stony Brook, NY
- 2004–present Adjunct Assistant Professor, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch
- 2001-2006 Assistant Professor, Department of Biomedical Engineering, SUNY Stony Brook, NY
- 2001–present Director, Integrative Skeletal Adaptation and Genetics Laboratory (ISAG), Stony Brook University, Stony Brook, NY
- 2011 Outstanding Service Award, Department of Biomedical Engineering, Stony Brook University
- 2007 The Best Academic/Pre-Professional Advisor andMentor, SUNY Stony Brook, The Student Choice Award
- 2006 New York City Research Initiative Achievement Award, NASA
- 2006 FASEB MARC Travel Award, Federation of American Societies for Experimental Biology (FASEB)
- 2005-2007 Early Career Translational Research Award, Wallace H. Coulter Foundation
- 2004 Award for Outstanding Teacher, Department of Biomedical Engineering, SUNY Stony Brook
Promising Young Scientist Award, International Society of Biomechanics
- 2002 Orthopaedic Biomechanics Award, IV World Congress of Biomechanics (Calgary)
- 2001 Young Investigator Award, American Society for Bone and Mineral Research (ASBMR)
- 2001 John Haddad Young Investigator Award, Advances in Mineral Metabolism (AIMM) and the American Society for Bone and Mineral Research (ASBMR)
- 1999-2001 Post-doctoral Fellowship, Alberta Heritage Foundation for Medical Research
- 1996 New Investigator Award (Open level) of the Canadian Society for Biomechanics
- 1996 URGC Graduate Travel Grant, University of Calgary
- 1995-1999 Full-Time Studentship, Alberta Heritage Foundation for Medical Research
Recent ISAG Publications
- Judex, S., Luu, Y.K., Ozcivici, E., Adler, B., Lublinsky, S., Rubin, C.T. (2010) Quantification of adiposity in small rodents using micro-CT. Methods 50(1), 14-19.
- Ozcivici, E., Luu, Y.K., Rubin, C.T., Judex, S. (2010) Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation. PLoS ONE 5(6): e11178. doi:10.1371/journal.pone.0011178.
- Holguin, N., Judex, S. (2010) Rat intervertebral disc health during hindlimb unloading: brief ambulation with or without vibration. Aviation, Space, and Environmental Medicine 81(12): 1078-1084.
- Holguin, N., Uzer, G., Chiang, F.P., Rubin, C., Judex, S. (2011) Brief daily exposure to low intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. Journal of Applied Physiology 111(6), 1846-53.
- Tommasini, S., Trinward, A., Acerbo, A.S., De Carlo, F., Miller, L.M., Judex, S. (2012) Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT. Bone 50(3), 596–604.
- Gupta, S., Manske, S.L., Judex, S. (2012) Increasing the number of unloading/reambulation cycles does not adversely impact body composition and lumbar bone mineral density but reduces tissue sensitivity. Acta Astronautica.
- Uzer, G., Manske, S.L., Chan, E., Chiang, F.P., Rubin, C.T., Frame, M.D., Judex, S. (2012) Separating fluid shear stress from acceleration during vibrations in vitro: identification of mechanical signals modulating the cellular response. Cellular and Molecular Bioengineering.
- Gupta, S., Vijayaraghavan, S., Gunes, U., Judex, S. (in press) Multiple exposures to unloading decrease bone’s responsivity but compound skeletal losses in C57BL/6 mice. American Journal of Physiology.
- SUNY-BNL Seed Grant
- Stony Brook School of Medicine
- The Coulter Foundation
- The Whitaker Foundation
- US Army
- BME 212 BME Research Fundamentals
- BME 303 Biomechanics
- BME 475 Undergraduate Teaching Practicum
- BME 449 Research in Biomedical Engineering
- BME 508 Molecular and Cellular Biomechanics