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Wei Yin

T: 631.632.1897
F: 631.632.8577
E:

Office:
Bioengineering 109
Stony Brook, NY
11794-5281

Wei Yin

Research Focus

Cardiovascular disease is the leading cause of death in the United Sates, and coronary artery disease is the most common type of cardiovascular disease. Shear stress induced by blood flow plays an important role in the initiation and development of atherosclerosis, the major reason for coronary artery disease. Circulating platelets and vascular endothelial cells are very sensitive to their mechanical environment; any change can affect their functions and interactions significantly. My major research interest is to investigate how altered blood flow and stress distribution affect platelet and endothelial cell behavior and lead to cardiovascular disease initiation. Computational fluid dynamics modeling, along with in vitro and ex vivo experiments, are carried out to study platelet and endothelial cell responses under physiologically relevant dynamic conditions. Biomarkers associated with platelet and endothelial cell activation are of special interest to us. We also work on numerical models to describe platelet coagulation kinetics and platelet adhesion to injured blood vessel wall under dynamic flow conditions.

Area of Interest

  • Cardiovascular dynamics and computational fluid dynamics
  • Platelet and endothelial cell functions under physiological and pathological flow conditions
  • Cardiovascular disease related inflammatory responses, especially complement activation
  • Effects of secondhand smoke on the development of cardiovascular diseases
  • Biomarker identification in cardiovascular diseases
  • Biomedical applications of aerogels
  • Education

    • M.S. Biomedical Engineering, 2001, The University of Akron, Akron, OH
    • Ph.D. Biomedical Engineering, 2004, SUNY at Stony Brook, Stony Brook, NY

    Professional Experience

    • 2005 – 2007 Post-doctoral research fellow, Department of Pathology, Weill Medical College of Cornell University, New York, NY
    • 2007 - 2013 Assistant Professor, School of Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, Oklahoma
    • 2013 – present Assistant professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY

    Professional Activities and Affiliations

    Reviewer:

    • Annals of Biomedical Engineering
    • Platelets
    • ASME Journal of Biomechanical Engineering
    • ASAIO Journal
    • American Heart Association
    • National Institutes of Health

    Membership:

    • American Heart Association
    • Biomedical Engineering Society
    • American Society of Hematology

    Educational:

    • Advisor for Biomedical Engineering Society Student Chapter (2013 – present)
    • Pre-Med advisor for Mechanical and Aerospace Engineering (Oklahoma State University, 2009 – 2013)
    • Advisor for Biomedical Engineering Seminar Series (Oklahoma State University, 2007 – 2008)

    Publications

    Books/Book Chapters

    • Wei Yin and David A. Rubenstein. Chapter 30: Biomedical Applications of Aerogels in Aerogels Handbook edited by Michael Aegerter, Nicholas Leventis and Matthias Koebel. Springer; New York, 2011. ISBN-13: 978-1-4419-7477-8.
    • David A. Rubenstein, Wei Yin and Mary D. Frame. Biofluid Mechanics: An Introduction to Biofluid Mechanics, Macrocirculation and Microcirculation. Elsevier; Massachusetts, 2012. ISBN-13: 978-0-12-381383-1.

    Peer Reviewed Journal Articles

    • Hasan, M., Rubenstein, D.A., and Yin, W. Effects of cyclic motion on coronary blood flow. Journal of Biomechanical Engineering. 135; 12: 121002-8, 2013.
    • Yin, W. and Rubenstein, D.A. Differences between mainstream and side stream tobacco smoke extracts and nicotine in the activation and aggregation of platelets subjected to diabetic cardiovascular conditions. Diabetes and Vascular Disease Research. 10; 1: 57-64, 2013.
    • Yin, W., Lu, H., Leventis, N. and Rubenstein, D.A. Characterization of the biocompatibility and mechanical properties of polyurea organic aerogels with blood and vascular endothelial cells – aerogel potential applications in blood implantable devices. International Journal of Polymeric Materials and Polymeric Biomaterials. 62; 2: 109-118, 2013.
    • Yin, W., Ngwe, E.C., and Rubenstein, D. A. A biocompatible flow chamber to study the hemodynamic performance of prosthetic heart valves. ASAIO Journal. 58; 5: 470-80, 2012.
    • David A. Rubenstein, Hongbing Lu, Shruti S. Mahadik, Nicholas Leventis and Wei Yin. Characterization of the Physical Properties and Biocompatibility of Polybenzoxazine Based Aerogels for use as a Novel Hard Tissue Scaffold. Journal of Biomaterials Science Polymer Edition. 23; 9: 1171-84, 2012.
    • Rubenstein, D.A., Maria, Z., and Yin, W. Glycated albumin modulates endothelial cell thrombogenic and inflammatory responses. J Diabetes Sci Technol. 5; 3: 703-13, 2011.
    • Maria, Z., Yin, W. and Rubenstein, D.A. Glycated albumin and pathological shear stress alters endothelial cell thrombogenic potential, pro-inflammatory state and cytoskeletal dynamics. Journal of Diabetes and Metabolism. S4:003, 2011. DOI:10.4172/2155-6156.S4-003.
    • Shanmugavelayudam, S.K., Rubenstein, D.A. and Yin, W. Effects of physiologically relevant dynamic shear stress on platelet complement activation. Platelets. 22; 8:602-10, 2011.
    • Shaw, J.H., Xiang, L., Shah A., Yin, W. and Lloyd P.G. Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. American Journal of Physiology. 300; 2: C349-55, 2011.
    • Yin, W. Shanmugavelayudam, S.K. Rubenstein, D.A. The effect of physiologically relevant dynamic shear stress on platelet and endothelial cell activation. Thrombosis Research. 127; 3: 235-41, 2011.
    • Rubenstein, D.A., Morton, B.E. and Yin, W. The combined effects of side stream smoke extracts and glycated serum albumin on endothelial cells and platelets. Cardiovascular diabetology. 9:28, 2010.
    • Shanmugavelayudam, S.K., Rubenstein, D.A. and Yin, W. Effect of geometrical assumptions on numerical modeling of coronary blood flow under normal and disease conditions. ASME Journal of Biomechanical Engineering. 132: 061004-1-8; 2010.
    • Rubenstein, D.A., Venkitachalam, S.M., Zamfir, D., Wang F., Lu, H., Frame, M.D. and Yin, W. In vitro biocompatibility of sheath-core cellulose-acetate-based electrospun scaffolds towards endothelial cells and platelets. Journal of Biomaterials Science. 21: 1716-1736, 2010.
    • Rubenstein D.A. and Yin W. Quantifying the Effects of Shear Stress and Shear Exposure Duration Regulation on Flow Induced Platelet Activation and Aggregation. Journal of Thrombosis and Thrombolysis. 30; 1: 36-45, 2010.
    • Peerschke EI, Yin, W. and Ghebrehiwet, B. Complement activation on platelets: implication for vascular inflammation and thrombosis. Molecular Immunology. 47 (13): 2170-5; 2010.
    • Peerschke EIB, Andemariam MD, Yin W and Bussel JB. Complement activation on platelets correlates with a decrease in circulating platelets in patients with immune thrombocytompenic purpura. British Journal of Hematology. British Journal of Haematology. 148; 4: 638-45; 2010.
    • Yin, W., Venkitachalam, S., Jarrett, E., Staggs,S., Leventis, N., Lu, H., Rubenstein, D.A. Biocompatibility of Polyurea Nanoencapsulated Templated Silica Aerogel. Journal of biomedical materials research part A. 92A:1431-1439, 2010.
    • Yin, W. and Rubenstein, D.A. Dose effect of shear stress on platelet complement activation in a dynamic cone and plate shearing device. Cellular and Molecular Bioengineering. 2; 2:274-280, 2009.
    • Rubenstein, D. A. and Yin, W. Glycated albumin modulates platelet susceptibility to flow induced activation and aggregation. Platelets, 20; 3: 206-215, 2009.
    • Peerschke, E.I., Yin, W., Alpert, D.R., Roubey, R.A.S., Salmon, J.E. Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies. LUPUS, 18; 6:530-8, 2009.
    • Peerschke EI, Yin W and Ghebrehiwet B. Platelet mediated complement activation. Adv Exp Med Biol. 632:81-91, 2008.
    • Yin, W., Czuchlewski, D., Leonard, D. and Peerschke, EIB. Development of proteomic signatures of platelet activation using surface enhanced laser desorption/ionization technology in a clinical setting. American Journal of Clinical Pathology. 129:862-869, 2008.
    • Yin, W., Ghebrehiwet, B., Peerschke, EI. Expression of complement components and inhibitors on platelet microparticles. Platelets, 19:225-233, 2008.
    • Yin, W., Ghebrehiwet, B., Weksler, B., Peerschke, EI. Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress. Thrombosis Research, 122:221-228, 2008.
    • Alpert, D., Mandl, L., Erkan, D., Yin, W., Peerschke, E.I., Salmon, J.E. Anti-heparin platelet factor 4 antibodies in systemic lupus erythematosus are associated with IgM antiphospholipid antibodies and the antiphospholipid syndrome. Ann Rheum Dis, 67; 3: 395-401, 2008.
    • Peerschke EI, Silver RT, Weksler BB, Yin, W, Bernhardt B, Varon D. Examination of platelet function in whole blood under dynamic flow conditions with the cone and plate(let) analyzer: effect of erythrocytosis and thrombocytosis. Am J Clin Pathol. 127; 3: 422-428, 2007.
    • Yin, W., Ghebrehiwet, B., Weksler, B. and Peerschke, E. Classical Pathway Complement Activation on Human Endothelial Cells. Molecular Immunology. 44; 9: 2228-34, 2007.
    • Peerschke, E.I.B., Yin, W., Grigg, S.E. and Ghebrehiwet, B. Blood platelets activate the classical pathway of human complement. Journal of thrombosis and Haemostasis, 4: 2035-42, 2006.
    • Yin, W., Krukenkamp, I.B., Gaudette, G, Jesty, J. and Bluestein, D. The thrombogenic performance of a St. Jude Bileaflet MHV in a sheep model. ASAIO Journal. 52; 1: 28-33, 2006.
    • Yin, W., Gallocher, S., Pinchuk, L., Schoephoerster, R., Jesty, J. and Bluestein, D. Flow induced platelet activation in a St. Jude MHV, a trileaflet polymeric heart valve and a St. Jude tissue valve. Artificial Organs, 29; 10: 826-31, 2005.
    • Yin, W. , Yared, A., Jesty, J., Affeld, K., Bluestein, D. Flow induced platelet activation in bileaflet and monoleaflet mechanical heart valves in a left ventricular assist device. Annals of biomedical eng. 32; 8: 1058-1066, 2004.
    • Bluestein, D., Yin, W., Affeld, K., Jesty, J. Flow-induced platelet activation in a mechanical heart valve. J. Heart valve disease. 13; 3: 501-508, 2004.
    • Jesty, J., Yin W., Perrotta, P., Bluestein, D. Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time. Platelets, 12: 11-17, 2003.

    Courses Taught

    • BME 440 – Biomedical Engineering Design (SBU)
    • ENGR 1111 – Introduction to Engineering (OSU)
    • MAE 3013 – Engineering Analysis (OSU)
    • MAE 3113 – Measurements and Instrumentation (OSU)
    • MAE 3723 – Dynamic Systems (OSU)
    • MAE 4623 – Biomechanics (OSU)
    • MAE 5013 – Basic Physiology for Engineers (OSU)
    • MAE 5053 – Advanced Engineering Statistics and Design of Experiments (OSU)